作者: meretricious 時(shí)間: 2025-3-21 20:16 作者: habile 時(shí)間: 2025-3-22 02:38
How to Take a Biopsyof invading inflammatory cells, and the presence, class, and distribution pattern of autoantibodies. For this, one needs to take a biopsy from a location with smallest change of sample error and specially fixate and the transport the specimen for the requested microscopic technique. All together, th作者: amplitude 時(shí)間: 2025-3-22 05:23
Direct Immunofluorescence Microscopy is to detect in vivo antibodies in patient’s skin or mucosa. Direct immunofluorescence of pemphigus shows depositions of immunoglobulins and/or complement on the epithelial cell surface of keratinocytes, whereas pemphigoid shows linear deposition of immunoglobulins along the epidermal basement memb作者: 總 時(shí)間: 2025-3-22 09:51 作者: linear 時(shí)間: 2025-3-22 16:25
Immunoassays of individual patients. The three main immunoassays are immunoblotting, immunoprecipitation, and ELISA. All three make use of the ability of the autoimmune IgG to bind to the target antigen. Immunoblotting is used to visualize the apparent molecular mass of the antigen, thereby enabling its identif作者: indenture 時(shí)間: 2025-3-22 18:01
Structure of Desmosomes the tissue. Major proteins that compose desmosomes are desmogleins, desmocollins, plakoglobin, plakophilins, and desmoplakin. Isoforms of desmosomal proteins have different distribution in tissues, some of them being more ubiquitous and others being expressed only in specific tissues. The importanc作者: cortex 時(shí)間: 2025-3-23 00:11
Pemphigus Vulgarisor desmoglein 3 (Table .). Pemphigus can be divided into two major forms, pemphigus foliaceus (PF) and pemphigus vulgaris (PV). The mucosal dominant form of PV is characterised by blistering of the mucous membranes and antibodies directed against desmoglein 3. Patients with mucocutaneous PV have bli作者: 沒有貧窮 時(shí)間: 2025-3-23 03:51
Pemphigus Foliaceusis. The common characteristic is the frequent presence of pathogenic anti-desmoglein 1 antibodies leading to bullae in the skin. Other characteristics – clinical, histological, pathogenesis, and therapy – vary and are specified in this chapter..Pemphigus foliaceus Cazenave first described by Cazenav作者: 消毒 時(shí)間: 2025-3-23 06:16 作者: grandiose 時(shí)間: 2025-3-23 13:20 作者: 怒目而視 時(shí)間: 2025-3-23 15:22
Drug-Induced Pemphigusthe drug to onset of the reaction is often relatively long compared to other cutaneous adverse drug reactions. Clinically, it can present as pemphigus foliaceus (most often), pemphigus erythematosus, pemphigus herpetiformis, or pemphigus vulgaris. Opposing to idiopathic pemphigus, pruritus, a prodro作者: languor 時(shí)間: 2025-3-23 20:31
Structure of Hemidesmosomes and the Epidermal Basement Membrane Zoneng mechanical attachment, these adhesion units are extremely dynamic. They play a significant role in signaling pathways involved in the various important cell functions, such as differentiation, wound healing, and survival. Structurally, hemidesmosomes contain the following molecules: plectin (over作者: 混合 時(shí)間: 2025-3-24 01:03
Cutaneous Pemphigoidfferent structural proteins of hemidesmosomes in the epidermal basement membrane zone (EBMZ) (Table. 14.1). Cutaneous pemphigoid includes many subtypes, such as bullous pemphigoid (BP), nonbullous cutaneous pemphigoid (NBCP), Brunsting-Perry cicatricial pemphigoid, lichen planus pemphigoides (LPP), 作者: Pcos971 時(shí)間: 2025-3-24 04:55
Mucous Membrane Pemphigoidoms and target antigens, such as ocular mucous membrane pemphigoid (OMMP), localized vulvar pemphigoid (LVP), and anti-laminin 332 MMP (anti-LN-332 MMP). Autoantibodies are directed against various structural proteins in the epidermal basement membrane zone (EBMZ), with the 180-kD antigen (BP180) as作者: 易發(fā)怒 時(shí)間: 2025-3-24 07:49
Epidermolysis Bullosa Acquisitaa. This subtype with scarring is named mechanobullous EBA, because blisters are evoked by sudden mechanical trauma, such as hitting the back of the hand to the edge of a table. The other subtype with erythematous lesions without scarring is named inflammatory EBA and may look like bullous pemphigoid作者: 我就不公正 時(shí)間: 2025-3-24 12:58
IgA Pemphigusss against desmosomal and non-desmosomal proteins of the epidermis. Based on the clinics, histology, direct immunofluorescence, and autoantibody profile, it is classified in two types: the subcorneal pustulosis dermatosis (SPD)-type and the intraepidermal neutrophilic IgA dermatosis (IEN)-type. The first-line therapy is dapsone.作者: 組裝 時(shí)間: 2025-3-24 15:15 作者: heart-murmur 時(shí)間: 2025-3-24 19:47
Springer International Publishing Switzerland 2016作者: happiness 時(shí)間: 2025-3-25 02:35
,?Massaker am Ich“, Rausch, Turbulenz,ss against desmosomal and non-desmosomal proteins of the epidermis. Based on the clinics, histology, direct immunofluorescence, and autoantibody profile, it is classified in two types: the subcorneal pustulosis dermatosis (SPD)-type and the intraepidermal neutrophilic IgA dermatosis (IEN)-type. The first-line therapy is dapsone.作者: Largess 時(shí)間: 2025-3-25 03:24
https://doi.org/10.1007/978-3-642-52237-6nt system that can act rapidly to eradicate microbes. The primary cells of the innate immune system are macrophages, granulocytes, natural killer cells, and dendritic cells. The adaptive system can be divided in a humoral and cellular response. The humoral response is characterized by activation of 作者: cunning 時(shí)間: 2025-3-25 10:13 作者: 小溪 時(shí)間: 2025-3-25 13:02 作者: Assault 時(shí)間: 2025-3-25 19:19
https://doi.org/10.1007/978-3-642-52237-6 is to detect in vivo antibodies in patient’s skin or mucosa. Direct immunofluorescence of pemphigus shows depositions of immunoglobulins and/or complement on the epithelial cell surface of keratinocytes, whereas pemphigoid shows linear deposition of immunoglobulins along the epidermal basement memb作者: 延期 時(shí)間: 2025-3-25 20:39
Gestagene in oralen Kontrazeptivais necessary to visualize these antibodies. Monkey esophagus is the most widely used substrate for detecting circulating autoantibodies in patients with autoimmune bullous diseases. In all variants of pemphigus, antibodies show an epithelial cell surface pattern, resulting from present autoantibodie作者: 名字 時(shí)間: 2025-3-26 00:42 作者: Halfhearted 時(shí)間: 2025-3-26 06:14 作者: 匍匐 時(shí)間: 2025-3-26 09:31 作者: Pert敏捷 時(shí)間: 2025-3-26 15:45 作者: PANIC 時(shí)間: 2025-3-26 19:30
https://doi.org/10.1007/978-3-642-40529-7iation with an underlying neoplasia. Pulmonary involvement may also occur. The pathogenesis involves the production of autoantibodies against desmogleins, plakins, and the protease inhibitor alpha-2-macroglobulin-like 1, but T-cell-mediated autoimmunity is also thought to play a role. Diagnosis usua作者: 遺產(chǎn) 時(shí)間: 2025-3-26 21:14
,?Massaker am Ich“, Rausch, Turbulenz,ss against desmosomal and non-desmosomal proteins of the epidermis. Based on the clinics, histology, direct immunofluorescence, and autoantibody profile, it is classified in two types: the subcorneal pustulosis dermatosis (SPD)-type and the intraepidermal neutrophilic IgA dermatosis (IEN)-type. The 作者: Nerve-Block 時(shí)間: 2025-3-27 04:21
Gestalten der Kontingenz: Ein Bilderbuchthe drug to onset of the reaction is often relatively long compared to other cutaneous adverse drug reactions. Clinically, it can present as pemphigus foliaceus (most often), pemphigus erythematosus, pemphigus herpetiformis, or pemphigus vulgaris. Opposing to idiopathic pemphigus, pruritus, a prodro作者: 壯觀的游行 時(shí)間: 2025-3-27 08:06
Franziska Kynast,Horst Kleinertng mechanical attachment, these adhesion units are extremely dynamic. They play a significant role in signaling pathways involved in the various important cell functions, such as differentiation, wound healing, and survival. Structurally, hemidesmosomes contain the following molecules: plectin (over作者: 否決 時(shí)間: 2025-3-27 09:28 作者: Ascendancy 時(shí)間: 2025-3-27 16:53
https://doi.org/10.1007/978-3-663-01245-0oms and target antigens, such as ocular mucous membrane pemphigoid (OMMP), localized vulvar pemphigoid (LVP), and anti-laminin 332 MMP (anti-LN-332 MMP). Autoantibodies are directed against various structural proteins in the epidermal basement membrane zone (EBMZ), with the 180-kD antigen (BP180) as作者: Endometrium 時(shí)間: 2025-3-27 18:09
https://doi.org/10.1007/978-3-658-04276-9a. This subtype with scarring is named mechanobullous EBA, because blisters are evoked by sudden mechanical trauma, such as hitting the back of the hand to the edge of a table. The other subtype with erythematous lesions without scarring is named inflammatory EBA and may look like bullous pemphigoid作者: 作嘔 時(shí)間: 2025-3-28 01:36
Marcel F. JonkmanQuickly learnable study guide with clear lists and tables, visual diagrams.Clear and practical information.Self-assessment with open questions at end of chapters?作者: 陪審團(tuán)每個(gè)人 時(shí)間: 2025-3-28 03:25
http://image.papertrans.cn/b/image/166140.jpg作者: Commemorate 時(shí)間: 2025-3-28 09:23
How to Take a Biopsyis is the playing ground of the dermatologist. Due to special transport requirements, dermatologists even take conjunctiva biopsies for immunofluorescence (IF) in case of suspicion of an autoimmune bullous disease of the eye.作者: 內(nèi)閣 時(shí)間: 2025-3-28 11:14
Drug-Induced Pemphigusmal stage, and absence of mucosal involvement are frequent, while laboratory findings are similar. The pathogenesis is not completely known, but probably includes endogenous and exogenous factors. Withdrawal of the culprit drug is mandatory, although the disease may not subside if caused by nonthiol drugs.作者: 一美元 時(shí)間: 2025-3-28 17:50
Book 20161st editionines can use the book as a quick reference guide when dealing with these patients. The book contains protocols and follows international guidelines.?Currently there is no quick primer on Autoimmune Bullous Diseases for dermatologists who wish to learn the subtleties of diagnosis and management of th作者: 原來 時(shí)間: 2025-3-28 18:57 作者: 不真 時(shí)間: 2025-3-28 23:40 作者: 饒舌的人 時(shí)間: 2025-3-29 06:35
ns at end of chapters??This book provides obligatory study material on courses on autoimmune bullous diseases. Residents and researchers in dermatology and adjacent disciplines can use the book as a quick reference guide when dealing with these patients. The book contains protocols and follows inter作者: 防水 時(shí)間: 2025-3-29 10:39
Gestagene in oralen Kontrazeptivanes of the mouth, nose, eyes, and genitals need to be examined systematically. Disease activity and extent of the skin and mucous membranes can be assessed using disease activity outcome measures that are validated for pemphigus, bullous pemphigoid, and mucous membrane pemphigoid.作者: elastic 時(shí)間: 2025-3-29 12:57
https://doi.org/10.1007/978-3-642-52237-6proteins have different distribution in tissues, some of them being more ubiquitous and others being expressed only in specific tissues. The importance of desmosomal proteins for sustaining epithelial architecture is demonstrated in genetic, autoimmune, and infectious human blistering diseases.作者: 歡呼 時(shí)間: 2025-3-29 18:52
Dermatological Examination of Bullous Diseasesnes of the mouth, nose, eyes, and genitals need to be examined systematically. Disease activity and extent of the skin and mucous membranes can be assessed using disease activity outcome measures that are validated for pemphigus, bullous pemphigoid, and mucous membrane pemphigoid.作者: Affectation 時(shí)間: 2025-3-29 22:56
Structure of Desmosomesproteins have different distribution in tissues, some of them being more ubiquitous and others being expressed only in specific tissues. The importance of desmosomal proteins for sustaining epithelial architecture is demonstrated in genetic, autoimmune, and infectious human blistering diseases.作者: BRACE 時(shí)間: 2025-3-30 03:18 作者: AGGER 時(shí)間: 2025-3-30 06:15 作者: GENRE 時(shí)間: 2025-3-30 10:21
https://doi.org/10.1007/978-3-642-40529-7sive agents and treatment of the underlying neoplasia. Despite treatment, paraneoplastic pemphigus has high mortality rates, often due to sepsis, respiratory failure, or progression of the underlying malignancy.作者: anarchist 時(shí)間: 2025-3-30 12:59
https://doi.org/10.1007/978-3-658-04276-9orescence microscopy. The pathogenesis of both clinical subtypes is unknown and is not related to binding of a particular epitope of the autoantigen. EBA is associated with systemic lupus erythematosus and colitis ulcerosa. The disease is relative refractory to treatment.作者: ovation 時(shí)間: 2025-3-30 20:07
Basic Principles of the Immune System and Autoimmunityseases. Autoimmune bullous diseases are the result of type II hypersensitivity, e.g., autoantibodies are directed against cell or matrix components. In pemphigoid diseases, antibodies are directed against hemidesmosomal components, whereas pemphigus is characterized by antibodies against desmosomal proteins.作者: 概觀 時(shí)間: 2025-3-31 00:38
Direct Immunofluorescence Microscopys to a sublamina densa, binding diseases caused by autoantibodies against type VII collagen, e.g., epidermolysis bullosa acquisita. Finally, dermatitis herpetiformis shows a granular IgA deposition along the epidermal basement membrane zone.作者: Palpable 時(shí)間: 2025-3-31 04:29
Paraneoplastic Pemphigussive agents and treatment of the underlying neoplasia. Despite treatment, paraneoplastic pemphigus has high mortality rates, often due to sepsis, respiratory failure, or progression of the underlying malignancy.作者: Mechanics 時(shí)間: 2025-3-31 09:06
Epidermolysis Bullosa Acquisitaorescence microscopy. The pathogenesis of both clinical subtypes is unknown and is not related to binding of a particular epitope of the autoantigen. EBA is associated with systemic lupus erythematosus and colitis ulcerosa. The disease is relative refractory to treatment.作者: 外觀 時(shí)間: 2025-3-31 10:53 作者: parasite 時(shí)間: 2025-3-31 14:08
https://doi.org/10.1007/978-3-642-52237-6hological examination, immunofluorescence microscopy and enzyme-linked immunosorbent assays (ELISA). Treatment of pemphigus vulgaris comprises systemic corticosteroids, together with adjuvant immunosuppressive drugs and/or rituximab.
