標題: Titlebook: Ataxia-Telangiectasia; Richard A. Gatti,Robert B. Painter Conference proceedings 1993 Springer-Verlag Berlin Heidelberg 1993 Ataxia-Telang [打印本頁] 作者: 倒鉤 時間: 2025-3-21 19:17
書目名稱Ataxia-Telangiectasia影響因子(影響力)
書目名稱Ataxia-Telangiectasia影響因子(影響力)學科排名
書目名稱Ataxia-Telangiectasia網(wǎng)絡(luò)公開度
書目名稱Ataxia-Telangiectasia網(wǎng)絡(luò)公開度學科排名
書目名稱Ataxia-Telangiectasia被引頻次
書目名稱Ataxia-Telangiectasia被引頻次學科排名
書目名稱Ataxia-Telangiectasia年度引用
書目名稱Ataxia-Telangiectasia年度引用學科排名
書目名稱Ataxia-Telangiectasia讀者反饋
書目名稱Ataxia-Telangiectasia讀者反饋學科排名
作者: 信條 時間: 2025-3-21 22:58
Frankreichs Verfassung 1958–2008ations were the cause for the increased incidence and suggested, therefore, that mammography screening may not be beneficial for A-T heterozygotes. We emphatically disagree: mammography screening is particularly beneficial for A-T heterozygotes whose risk for breast cancer is higher than for the general population.作者: 祖?zhèn)?nbsp; 時間: 2025-3-22 04:05 作者: harmony 時間: 2025-3-22 05:40
Conference proceedings 1993e body parts ascerebellum, thymus and chromosomes. The patients areundulysensitive to ionizing radiation, immunodeficient, and athird of them develops cancer. All of this stems fromdefects of a singlegene.Provided here is an up-to-date review of all important workin thefield. A wide spectrum of topi作者: exceed 時間: 2025-3-22 12:16 作者: 擁護 時間: 2025-3-22 14:42
Bildungsdiskussionen in Frankreichd A,C,D and E) have been described (Jaspers ., 1988); although the disease is clinically indistinguishable in the four groups, radiation-sensitivity is rendered normal by fusion of cells deriving from A-T patients from different groups (whereas fusion of cells from patients from the same group has no effect).作者: defenses 時間: 2025-3-22 19:43
https://doi.org/10.1007/978-3-531-91665-1 to a defect in rejoining of radiation-induced DNA double strand breaks. Hence, the site-specific V(D)J DNA recombination process has been linked to the repair of randomly-induced double-strand breaks.作者: GRE 時間: 2025-3-22 22:28
Cloning and Characterization of a Candidate Gene for A-T Complementation Group Dtially radioresistant when compared with the original A-T cell line. This approach was begun in this Laboratory in 1983 and resulted in the isolation of a candidate A-T gene at the end of 1990. Currently, work is in progress to characterize this candidate gene and to determine whether it is the gene for A-T complementation group D.作者: Incorruptible 時間: 2025-3-23 05:23 作者: LINES 時間: 2025-3-23 09:29
Murine scid cells and human ataxia-telangiectasia cells complement each other’s radiosensitivity to a defect in rejoining of radiation-induced DNA double strand breaks. Hence, the site-specific V(D)J DNA recombination process has been linked to the repair of randomly-induced double-strand breaks.作者: 門閂 時間: 2025-3-23 13:18
Conference proceedings 1993 cancer. All of this stems fromdefects of a singlegene.Provided here is an up-to-date review of all important workin thefield. A wide spectrum of topics is covered, namelygenetics, chromosome 11 mapping, radiobiology,complementation, heterozygote identification,clinicalvariants, biochemistry, and treatment of A-T.作者: penance 時間: 2025-3-23 16:03
Wolfgang Asholt,Frank Baasner,Wolfram Vogel applied to identify cell clones showing increased resistance to the lethal action of the DNA damaging agent. An attempt is then made to rescue the piece of DNA responsible for this phenotypic change, which is expected to represent a candidate gene.作者: Bravado 時間: 2025-3-23 19:03
Complementation of the Cellular A-T Phenotype by Gene Transfer applied to identify cell clones showing increased resistance to the lethal action of the DNA damaging agent. An attempt is then made to rescue the piece of DNA responsible for this phenotypic change, which is expected to represent a candidate gene.作者: 做方舟 時間: 2025-3-24 00:20
1010-8793 um of topics is covered, namelygenetics, chromosome 11 mapping, radiobiology,complementation, heterozygote identification,clinicalvariants, biochemistry, and treatment of A-T.978-3-642-78280-0978-3-642-78278-7Series ISSN 1010-8793 作者: 注入 時間: 2025-3-24 03:34 作者: 四海為家的人 時間: 2025-3-24 08:03 作者: oblique 時間: 2025-3-24 11:28 作者: COMMA 時間: 2025-3-24 15:12
How Many Ataxia-Telangiectasia Genes?In this chapter we review the evidence for genetic heterogeneity and clinical variability of A-T. Because of the existence of five complementation groups [Jasper et al. 1988], a homogeneity model is automatically suspect. There are also clinical variants of A-T, and those are discussed briefly.作者: 放氣 時間: 2025-3-24 19:09
Ataxia-Telangiectasia978-3-642-78278-7Series ISSN 1010-8793 作者: Tonometry 時間: 2025-3-25 02:12 作者: 專橫 時間: 2025-3-25 06:44 作者: 蒸發(fā) 時間: 2025-3-25 09:53 作者: 古代 時間: 2025-3-25 15:19 作者: Tempor 時間: 2025-3-25 17:34
Bildungsdiskussionen in Frankreicha high incidence of cancer and infection. Other distinctive features of the disease include: hypersensitivity of fibroblasts and lymphocytes to ionizing radiation; cellular and humoral immunodeficiencies; chromosomal instability and non-random chromosomal rearrangements in lymphocytes; and elevated 作者: 涂掉 時間: 2025-3-25 23:25
Wolfgang Asholt,Frank Baasner,Wolfram Vogelgic degeneration as well as for cellular responses to induced and spontaneous DNA damage. However, despite extensive investigation, no A-T gene has been identified to date and the site of action of the A-T gene product(s) is unknown.作者: Ruptured-Disk 時間: 2025-3-26 03:31 作者: 慢慢流出 時間: 2025-3-26 05:12
Bildungsdiskussionen in Frankreichthis disease (Taylor et al. 1975). Localization of the A-T gene to chromosome 11q22–23 was first suggested from a genetic linkage study (Gatti et al. 1988) and this has been followed by recent additional reports confirming that the genes responsible for A-T complementation groups A and C are located作者: infelicitous 時間: 2025-3-26 09:48
https://doi.org/10.1007/978-3-531-90640-9ectasia, immunodeficiency, hypersensitivity to ionizing radiation and predisposition to cancer (for review see Sedgwick and Boder, 1991). Despite extensive investigation, the molecular defect responsible for these pleiotropic abnormalities in A-T remains unknown.作者: 約會 時間: 2025-3-26 13:01 作者: 云狀 時間: 2025-3-26 19:14
https://doi.org/10.1007/978-3-531-90640-9eaction to conventional radiotherapy (Boder, 1985; Sedgwick and Boder, 1991). Radiation intolerance ., as manifested by impaired colony-forming ability and exessive chromosomal instability, is universally displayed by cultured dermal fibroblasts and peripheral blood lymphocytes derived from A-T dono作者: 熱心助人 時間: 2025-3-26 23:37
Frankreichs Verfassung 1958–2008t approximately 5% of breast cancers may be the result of a highly penetrant autosomal dominant gene (Claus ., 1991). Such individuals tend to develop breast cancer at an early age, have a high prevalence of bilaterality and are at an elevated risk of other neoplasms (Lynch and Hirayam, 1989). Recen作者: NOMAD 時間: 2025-3-27 02:29 作者: 增減字母法 時間: 2025-3-27 09:15
Das Parteiensystem der V. Republikecificity. The mechanisms remain undefined. The physical basis for the differential accessibility in this site-specific recombination reaction has been a matter of much speculation. Possibilities have included the processes of transcription (Ferrier et al., 1989; Martin et al., 1991; Schlissel et al作者: 人類 時間: 2025-3-27 12:01 作者: 不來 時間: 2025-3-27 16:01 作者: SIT 時間: 2025-3-27 17:46
Nato ASI Subseries H:http://image.papertrans.cn/b/image/163910.jpg作者: 臨時抱佛腳 時間: 2025-3-27 23:12
Isolation of Human cDNAS That Complement the Ataxia-Telangiectasia Phenotype in Cultured Fibroblastsgic degeneration as well as for cellular responses to induced and spontaneous DNA damage. However, despite extensive investigation, no A-T gene has been identified to date and the site of action of the A-T gene product(s) is unknown.作者: 正論 時間: 2025-3-28 05:12
AT-like Radiosensitive Rodent Cell Mutants: An Alternative Approach to the Isolation of the A-T Geneectasia, immunodeficiency, hypersensitivity to ionizing radiation and predisposition to cancer (for review see Sedgwick and Boder, 1991). Despite extensive investigation, the molecular defect responsible for these pleiotropic abnormalities in A-T remains unknown.作者: Terrace 時間: 2025-3-28 07:24
Ataxia-Telangiectasia: A Brief Historical Overview1963.. By 1963 it was possible to publish a review of 101 cases world-wide illustrating the stereotyped nature of the disorder: progressive cerebellar ataxia in childhood, autosomal recessive heredity, oculocutaneous telangiectasia, frequency of sinopulmonary infection, peculiarity of eye movements,作者: Myofibrils 時間: 2025-3-28 11:15 作者: arthroplasty 時間: 2025-3-28 15:27 作者: Facet-Joints 時間: 2025-3-28 21:31 作者: 野蠻 時間: 2025-3-29 02:35
Complementation of the Cellular A-T Phenotype by Gene Transfermon feature of these diseases, cellular sensitivity to specific DNA damaging agents. The advent of gene transfer methods supplied the experimental system for this approach, which is apparently simple and straightforward: Exogenous DNA is introduced in vitro into the patient’s cells, and selection is作者: 冷漠 時間: 2025-3-29 05:29
Use of Microcell Hybrids for Analysis of the 11q23 Region and Improved Localization of the A-T Groupthis disease (Taylor et al. 1975). Localization of the A-T gene to chromosome 11q22–23 was first suggested from a genetic linkage study (Gatti et al. 1988) and this has been followed by recent additional reports confirming that the genes responsible for A-T complementation groups A and C are located作者: landmark 時間: 2025-3-29 08:35
AT-like Radiosensitive Rodent Cell Mutants: An Alternative Approach to the Isolation of the A-T Geneectasia, immunodeficiency, hypersensitivity to ionizing radiation and predisposition to cancer (for review see Sedgwick and Boder, 1991). Despite extensive investigation, the molecular defect responsible for these pleiotropic abnormalities in A-T remains unknown.作者: deviate 時間: 2025-3-29 14:47
Identification of A-T heterozygoteshemicals (reviewed in Bridges and Harnden, 1982) the response of cells from heterozygotes has been investigated with many procedures (summarised by Weeks ., 1991). Most techniques are able to detect a shift in the . response of heterozygote cells compared with normals but with considerable overlap b作者: Vulvodynia 時間: 2025-3-29 15:52 作者: Crepitus 時間: 2025-3-29 19:48 作者: adduction 時間: 2025-3-30 02:57 作者: Ingrained 時間: 2025-3-30 08:02 作者: 有助于 時間: 2025-3-30 08:59 作者: forager 時間: 2025-3-30 13:16 作者: 宴會 時間: 2025-3-30 20:17
Ataxia-Telangiectasia: A Brief Historical Overviewence of the thymic deficiency and suggestion was made that A-T patients may be critical keys to the study of complex host factors involved in immunogenesis and malignancy. In 1968 the peculiar generalized nucleocytomegaly was recognized confirming the fact that A-T is a multisystem disorder..作者: 陰謀小團體 時間: 2025-3-30 21:18 作者: 弄皺 時間: 2025-3-31 01:51
Identification of A-T heterozygotesation frequencies than any of the heterozygotes. These studies were on cultured skin fibroblasts (20 heterozygotes and 17 controls for which there was complete discrimination; Parshad ., 1985; Shiloh ., 1986; Shiloh ., 1989) and peripheral blood lymphocytes (9 heterozygotes and 35 controls with over作者: 災難 時間: 2025-3-31 07:22 作者: corpuscle 時間: 2025-3-31 13:14 作者: fastness 時間: 2025-3-31 16:17
Lymphoid V(D)J Recombination: Accessibility and Reaction Fidelity in Normal and Ataxia-Telangiectasie temporal resolution of such studies has been limiting. They have not permitted determination of whether transcription and recombination are consequences of a common chromatin change or whether transcription precedes and, thereby, activates recombination.作者: DRILL 時間: 2025-3-31 20:44
