作者: Explosive 時間: 2025-3-21 22:11
Girolamo Pelaia,Alessandro Vatrella,Rosario MasellDescribes the rationale, mechanisms of action, and indications for use of biologics in asthma.Offers an excellent balance between basic science and analysis of clinical trials.Includes very clear illu作者: 走調(diào) 時間: 2025-3-22 00:23
http://image.papertrans.cn/b/image/163550.jpg作者: DRILL 時間: 2025-3-22 08:31
https://doi.org/10.1007/978-3-319-46007-9IL-13; IL-4; IL-5; airway remodelling in asthma; anti-IgE; anti-TNFalpha antibodies; cellular and molecula作者: Etymology 時間: 2025-3-22 11:56
978-3-319-83417-7Springer International Publishing Switzerland 2017作者: 不要不誠實(shí) 時間: 2025-3-22 14:42 作者: MAPLE 時間: 2025-3-22 18:18 作者: ARM 時間: 2025-3-23 00:44 作者: Endearing 時間: 2025-3-23 03:09
https://doi.org/10.1007/978-3-8348-9214-0airway structural cells, is a hallmark of asthma [1, 2]. Several inflammatory phenotypes of asthma have been characterized, which include eosinophilic, neutrophilic, mixed and paucigranulocytic patterns [3, 4]. Eosinophils are the inflammatory cells most frequently infiltrating the airways of asthma作者: INCH 時間: 2025-3-23 06:22
https://doi.org/10.1007/978-3-658-30557-4es which involve all layers of the bronchial wall, including large and small airways [1, 2]. Such structural changes, collectively referred as airway remodelling, likely originate from repetitive cycles of tissue injury, causing subsequent cellular responses leading to abnormal repair [3]. Although 作者: FIS 時間: 2025-3-23 12:34 作者: 有權(quán)威 時間: 2025-3-23 16:56 作者: 尖酸一點(diǎn) 時間: 2025-3-23 18:31 作者: 潛伏期 時間: 2025-3-23 23:24 作者: Myocyte 時間: 2025-3-24 02:54 作者: 咽下 時間: 2025-3-24 09:29 作者: Manifest 時間: 2025-3-24 13:48 作者: agenda 時間: 2025-3-24 15:09
Book 2017 It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, f作者: 抱狗不敢前 時間: 2025-3-24 19:58 作者: 失眠癥 時間: 2025-3-25 00:54
Wolfgang B?ge,Wilfried Pla?mannrapies, many of which are undergoing advanced stages of clinical investigation, will probably lead in the next future to the introduction in real life of several other biologics indicated for asthma treatment [7–11].作者: ironic 時間: 2025-3-25 05:28 作者: 評論性 時間: 2025-3-25 08:36
Conclusions and Future Perspectives,rapies, many of which are undergoing advanced stages of clinical investigation, will probably lead in the next future to the introduction in real life of several other biologics indicated for asthma treatment [7–11].作者: 小木槌 時間: 2025-3-25 12:07
https://doi.org/10.1007/978-3-8348-9214-0 different responses to pharmacological therapies [5, 6]. The majority of asthmatic patients can achieve a good control of their symptoms using standard treatments including inhaled corticosteroids and bronchodilators such as β.-adrenergic agonists, as well as oral leukotriene inhibitors [7, 8].作者: Diatribe 時間: 2025-3-25 18:17
https://doi.org/10.1007/978-3-658-30557-4 this key immunological discovery into the approval of the anti-IgE antibody omalizumab for the treatment of severe allergic asthma [7]. Indeed, omalizumab has been the first and for a long time the only biologic drug available in clinical practice for add-on therapy of uncontrolled asthma [8].作者: 西瓜 時間: 2025-3-25 22:15
Wilfried Pla?mann,Detlef Schulzeroids, some subgroups of asthmatic subjects display persistent bronchial and/or blood eosinophilia, associated with an inadequate control of asthma [8]. Therefore, these patients can potentially benefit from additional therapies based on the use of biologic drugs targeting IL-5.作者: Volatile-Oils 時間: 2025-3-26 00:52 作者: amnesia 時間: 2025-3-26 08:20 作者: 最小 時間: 2025-3-26 09:47
IL-5-Targeted Antibodies,eroids, some subgroups of asthmatic subjects display persistent bronchial and/or blood eosinophilia, associated with an inadequate control of asthma [8]. Therefore, these patients can potentially benefit from additional therapies based on the use of biologic drugs targeting IL-5.作者: debase 時間: 2025-3-26 14:31 作者: 脫水 時間: 2025-3-26 19:00 作者: Anterior 時間: 2025-3-26 21:45
Wilfried Pla?mann,Detlef Schulzr ability to induce type 2 innate lymphoid cells (ILC2s) to produce T2-type cytokines such as IL-5, IL-9 and IL-13 [2]. Therefore, IL-25, IL-33 and TSLP are suitable targets for antiasthma biological therapies [3].作者: 誹謗 時間: 2025-3-27 04:57 作者: 連鎖,連串 時間: 2025-3-27 05:18 作者: conflate 時間: 2025-3-27 13:03
Airway Remodelling in Asthma,es which involve all layers of the bronchial wall, including large and small airways [1, 2]. Such structural changes, collectively referred as airway remodelling, likely originate from repetitive cycles of tissue injury, causing subsequent cellular responses leading to abnormal repair [3]. Although 作者: eardrum 時間: 2025-3-27 14:15 作者: 詞匯表 時間: 2025-3-27 20:26 作者: Lucubrate 時間: 2025-3-28 01:15 作者: Kinetic 時間: 2025-3-28 05:41
,Anti-TNF-α Therapies, structural cells (Fig. 7.1) [1]. This pleiotropic cytokine is produced by several cell types including Th1 lymphocytes, macrophages and mast cells and induces the recruitment of neutrophils and eosinophils into the airways via up-regulation of epithelial and endothelial adhesion molecules [2, 3]. M作者: 侵略 時間: 2025-3-28 06:52 作者: 寵愛 時間: 2025-3-28 13:01 作者: 自作多情 時間: 2025-3-28 18:35 作者: 并排上下 時間: 2025-3-28 22:29 作者: 多山 時間: 2025-3-29 01:28
https://doi.org/10.1007/978-3-8348-9214-0) (Fig. 2.1). In addition to being driven by adaptive immune responses, airway eosinophilia can also arise from innate immune mechanisms, which are mediated by intercellular communications involving dendritic cells, bronchial epithelial cells and innate lymphoid cells [7, 8]. Whilst bronchial eosino作者: 痛苦一下 時間: 2025-3-29 04:50 作者: 疏忽 時間: 2025-3-29 08:09 作者: Proponent 時間: 2025-3-29 11:26
Airway Remodelling in Asthma, of chronic inflammation [6]. However, close interactions tightly connect the cellular and molecular mechanisms underpinning airway inflammation and remodelling (Fig. 3.1), and both pathologic processes certainly contribute together to induce bronchial hyperresponsiveness as well as asthma persisten作者: contrast-medium 時間: 2025-3-29 19:33
