標(biāo)題: Titlebook: Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research; M. R. Waterman,M. Hildebrand Conference proceedings 1994 Springe [打印本頁] 作者: firearm 時間: 2025-3-21 17:59
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書目名稱Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research讀者反饋
書目名稱Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research讀者反饋學(xué)科排名
作者: WITH 時間: 2025-3-21 23:31
Conference proceedings 20071st editionafter cell fractionation as microsomes. The liver has high P450 concentration, but P450s have near universal distribution, including but not limited to kidney, lung, and intestine, which are barrier organs to chemical entry.作者: mastopexy 時間: 2025-3-22 02:10
Haruo Sawada,Makoto Araki,Akira Shimizus. Many drug oxidations can now be attributed to a few, major P450 enzymes. Several lines of evidence suggest that the enzyme P450 3A4 is, on the average, the major P450 present in human liver, and that small intestine plays a significant role in the metabolism of many drugs.作者: 點燃 時間: 2025-3-22 07:16
Conference proceedings 20071st editionnd toxicological potential of a given xenobiotic in a given individual. Heterologous systems allowing the expression of cloned P450 are new tools that are very useful in the understanding of xeno-biotic metabolism since they allow working with a unique pure enzyme. This paper reviews the way in whic作者: slipped-disk 時間: 2025-3-22 09:35
Forest Fires in the Mediterranean Region especially for human enzymes. The availibility of gene libraries for cloning the wanted gene as cDNA, followed by heterologous expression of this cDNA bypasses these restrictions. This approach also substitutes drug metabolism studies in animals for drug safety studies in humans. Metabolism studies作者: 蘆筍 時間: 2025-3-22 14:09
Expression of Cytochromes P450 in Yeast: Practical Aspects,作者: Climate 時間: 2025-3-22 20:29 作者: 等待 時間: 2025-3-22 23:42 作者: 去掉 時間: 2025-3-23 05:15
Metabolic Reactions and Recombinant Isoenzymes of Cytochrome P450: Information Generated and Value after cell fractionation as microsomes. The liver has high P450 concentration, but P450s have near universal distribution, including but not limited to kidney, lung, and intestine, which are barrier organs to chemical entry.作者: placebo-effect 時間: 2025-3-23 07:43 作者: Silent-Ischemia 時間: 2025-3-23 13:05 作者: ingenue 時間: 2025-3-23 15:30 作者: 格言 時間: 2025-3-23 19:07
https://doi.org/10.1007/978-3-662-03019-6cytochrome P450; drug; drug research; enzymes; research作者: minion 時間: 2025-3-23 23:34
978-3-662-03021-9Springer-Verlag Berlin Heidelberg 1994作者: 轉(zhuǎn)折點 時間: 2025-3-24 02:27 作者: 沖擊力 時間: 2025-3-24 10:18 作者: 大看臺 時間: 2025-3-24 14:34
0947-6075 Overview: 978-3-662-03021-9978-3-662-03019-6Series ISSN 0947-6075 作者: 不在灌木叢中 時間: 2025-3-24 16:14
Pests of Logs, Lumber, and Forest Products,tochrome P450” on the basis of a Soret absorbance band when reduced and complexed with carbon monoxide (Omura and Sato 1961, 1964a,b). The latter property is due to the presence of a noncovalently bound heme in the form of protoporphyrin IX.作者: corn732 時間: 2025-3-24 20:19 作者: FAZE 時間: 2025-3-25 02:29
Xenobiotic Metabolism: From Intact Biosystem to Single Enzymes,The evolutionary process has yielded an endogenous system in living organisms that is able to transform and functionalize compounds for life requirements, deactivate them in the postfunctional phase, and thus provide the equipment for handling endo- and xenobiotics which we term metabolic capacity.作者: BROW 時間: 2025-3-25 06:19
Pests of Logs, Lumber, and Forest Products,tochrome P450” on the basis of a Soret absorbance band when reduced and complexed with carbon monoxide (Omura and Sato 1961, 1964a,b). The latter property is due to the presence of a noncovalently bound heme in the form of protoporphyrin IX.作者: 效果 時間: 2025-3-25 08:05
https://doi.org/10.1007/978-1-4020-6508-8micals. Studies over the past 20 years have provided evidence that cytochromes P450 occur in many different forms (isoforms or isozymes) which differ in spectral, chemical, and immunological properties and have different substrate affinities. These isozymes also differ in their regulation and tissue作者: 你正派 時間: 2025-3-25 13:58
Pests of Logs, Lumber, and Forest Products,and are widely used in cancer chemotherapy (reviewed by Sladek 1988). Cyclophosphamide and ifosphamide are therapeutically inactive prodrugs that must be activated by liver metabolism following administration to cancer patients. Early studies implicated liver cytochrome P450 as the catalyst of cyclo作者: 天真 時間: 2025-3-25 17:15
Pests of Flowers, Fruits, and Seeds,calization of the approximately 200 forms of human P450, (b) characterization of the enzymatic properties of these enzymes and thus their relatedness regarding overlapping substrate metabolism, and (c) determination of the structure-function relationships in human P450s. Over the past decade revolut作者: 詼諧 時間: 2025-3-25 23:20 作者: overweight 時間: 2025-3-26 02:45 作者: 生存環(huán)境 時間: 2025-3-26 06:28 作者: 躲債 時間: 2025-3-26 10:39 作者: 寬度 時間: 2025-3-26 14:14
https://doi.org/10.1007/978-94-017-1574-4f course beneficial for the control of the cellular levels of both endogenous and exogenous compounds. It is probable that this control system has evolved for survival purposes of the organisms, but an endogenously driven evolution in some specific cases cannot be excluded. The substrate-dependent P作者: 發(fā)電機 時間: 2025-3-26 19:20
Forest Fires in the Mediterranean Regionred to develop analytical tools. In this context, cell culture technology has made a very important contribution to the area of in vitro systems (Doehmer 1993). The combination of gene technology and cell culture technology has provided new opportunities for studying drug metabolism related problems作者: 時代 時間: 2025-3-27 00:40
Ernst Schering Foundation Symposium Proceedingshttp://image.papertrans.cn/b/image/163405.jpg作者: 相符 時間: 2025-3-27 04:52
Conference proceedings 20071st editiontabolism and also carcinogenesis, considerable effort has been devoted by many laboratories to the development of model systems to study human P450 metabolism (reviews: Gonzalez 1988; Guengerich 1988; Gonzalez et al. 1991; Langenbach et al. 1992).作者: bisphosphonate 時間: 2025-3-27 08:03 作者: 過度 時間: 2025-3-27 12:51 作者: follicle 時間: 2025-3-27 15:51 作者: FECK 時間: 2025-3-27 18:58 作者: TAIN 時間: 2025-3-28 00:47
Pests of Logs, Lumber, and Forest Products,bital or prednisone (Faber et al. 1974; Sladek 1972), agents that are known to induce liver P450 enzymes both in humans and in rats (Pichard et al. 1992). More recent studies carried out in this laboratory have validated this conclusion using purified and cDNA-expressed P450 enzymes, as summarized below (Chang et al. 1993; Clarke and Waxman 1989).作者: 航海太平洋 時間: 2025-3-28 06:09
Cytochrome P450 in Human Drug Metabolism: How Much Is Predictable?,rganism. Close to 30 human cytochrome P450 genes have now been characterized. The multiplicity of P450 isozymes explains in part the literally thousands of substrates known to be metabolized by this system (for review, see Nelson et al. 1993).作者: 分開如此和諧 時間: 2025-3-28 09:21 作者: plasma 時間: 2025-3-28 10:32
Regulation of Xenobiotic-Metabolizing Cytochromes P450,tochrome P450” on the basis of a Soret absorbance band when reduced and complexed with carbon monoxide (Omura and Sato 1961, 1964a,b). The latter property is due to the presence of a noncovalently bound heme in the form of protoporphyrin IX.作者: Infect 時間: 2025-3-28 15:05
Cytochrome P450 in Human Drug Metabolism: How Much Is Predictable?,micals. Studies over the past 20 years have provided evidence that cytochromes P450 occur in many different forms (isoforms or isozymes) which differ in spectral, chemical, and immunological properties and have different substrate affinities. These isozymes also differ in their regulation and tissue作者: sed-rate 時間: 2025-3-28 21:29
Metabolic Activation of Anticancer Oxazaphosphorines by Cytochrome P450s: Development of a Model foand are widely used in cancer chemotherapy (reviewed by Sladek 1988). Cyclophosphamide and ifosphamide are therapeutically inactive prodrugs that must be activated by liver metabolism following administration to cancer patients. Early studies implicated liver cytochrome P450 as the catalyst of cyclo作者: 狼群 時間: 2025-3-29 01:30
The Use of Bacteria for Cytochrome P450 Expression,calization of the approximately 200 forms of human P450, (b) characterization of the enzymatic properties of these enzymes and thus their relatedness regarding overlapping substrate metabolism, and (c) determination of the structure-function relationships in human P450s. Over the past decade revolut作者: Ferritin 時間: 2025-3-29 03:08
Human Cells as an Expression System for Cytochromes P450,athways of metabolism can influence the safety and/or efficacy of a drug or drug candidate. Because of the central role of cytochrome P450s in drug metabolism and also carcinogenesis, considerable effort has been devoted by many laboratories to the development of model systems to study human P450 me作者: circuit 時間: 2025-3-29 07:33 作者: ticlopidine 時間: 2025-3-29 12:54
The Importance of Cytochrome P450 3A Enzymes in Drug Metabolism,0 (P450) enzymes were reported more than 50 years ago (Mueller and Miller 1953; Brodie et al. 1958), and they are now recognized to be the major catalysts involved in the metabolism of drugs, steroids, carcinogens, pesticides, and pollutants (see entire January 1992 issue of .). There has been consi作者: legitimate 時間: 2025-3-29 18:13 作者: 材料等 時間: 2025-3-29 21:47 作者: 聽覺 時間: 2025-3-30 01:22
Strategies for the Use of Single Cytochrome P450 Enzymes in Drug Research and Future Prospects,red to develop analytical tools. In this context, cell culture technology has made a very important contribution to the area of in vitro systems (Doehmer 1993). The combination of gene technology and cell culture technology has provided new opportunities for studying drug metabolism related problems作者: arthroplasty 時間: 2025-3-30 05:59 作者: nutrition 時間: 2025-3-30 11:24
Quantitative temporal reasoning, the size of the RTCTL specification formula and in the size of the global state-space graph. Finally, we present an optimal, exponential time tableau-based decision procedure for the satisfiability of RTCTL formulae, which can be used as the basis of a technique to automate the synthesis of real-ti
