標題: Titlebook: Aspartic Proteinases; Retroviral and Cellu Michael N. G. James Book 1998 The Editor(s) (if applicable) and The Author(s), under exclusive l [打印本頁] 作者: 拖累 時間: 2025-3-21 18:50
書目名稱Aspartic Proteinases影響因子(影響力)
書目名稱Aspartic Proteinases影響因子(影響力)學科排名
書目名稱Aspartic Proteinases網(wǎng)絡(luò)公開度
書目名稱Aspartic Proteinases網(wǎng)絡(luò)公開度學科排名
書目名稱Aspartic Proteinases被引頻次
書目名稱Aspartic Proteinases被引頻次學科排名
書目名稱Aspartic Proteinases年度引用
書目名稱Aspartic Proteinases年度引用學科排名
書目名稱Aspartic Proteinases讀者反饋
書目名稱Aspartic Proteinases讀者反饋學科排名
作者: 機密 時間: 2025-3-21 23:41
Matthias Pilz,Susanne Berger,Roy Canningtability and half-life; and 5) mutations that provide new substrate specificities with corresponding mutations in the gag—pol polyprotein precursor substrate. Since the binding modes of both the natural substrates for HIV protease and the substrate analog class of inhibitors are similar, amino acid 作者: 孵卵器 時間: 2025-3-22 01:31
https://doi.org/10.1007/978-3-658-03521-1ol viral polypeptide. The kinetic data were interpreted with the aid of molecular modeling to understand the effect of mutations on inhibitor binding and processing of the gag-pol polypeptide to generate infective virions.作者: Pessary 時間: 2025-3-22 04:45
https://doi.org/10.1007/978-3-658-12181-5... They maintain the level of catalytic activity, allowing the virus to replicate, but they lower the affinity of the HIV-1 PR for the anti-viral drug, reducing the drug’s potential therapeutic power. At present, the molecular mechanisms that underlie drug resistance are not fully understood. Their作者: 為寵愛 時間: 2025-3-22 10:35 作者: 羊欄 時間: 2025-3-22 15:10 作者: Project 時間: 2025-3-22 20:53
Book 1998ountries. There were 26 invited speak- ers among the 44 oral presentations of the 7 main sessions. In addition, there were 53 con- tributed poster presentations that spanned the whole range of interest in aspartic proteinases.作者: omnibus 時間: 2025-3-22 22:46 作者: 投射 時間: 2025-3-23 02:14 作者: 蝕刻 時間: 2025-3-23 07:49
Optimization of a Macromolecular Inhibitor of HIV-1 Proteasetability and half-life; and 5) mutations that provide new substrate specificities with corresponding mutations in the gag—pol polyprotein precursor substrate. Since the binding modes of both the natural substrates for HIV protease and the substrate analog class of inhibitors are similar, amino acid 作者: Unsaturated-Fat 時間: 2025-3-23 09:48
Selection and Characterization of VX-478 Resistant HIV-1 Variantsol viral polypeptide. The kinetic data were interpreted with the aid of molecular modeling to understand the effect of mutations on inhibitor binding and processing of the gag-pol polypeptide to generate infective virions.作者: 否決 時間: 2025-3-23 15:00 作者: gospel 時間: 2025-3-23 19:40 作者: CAMP 時間: 2025-3-23 23:13 作者: adhesive 時間: 2025-3-24 02:41
Paul G. Fitzgerald,Marco G. Malusàmewhat primitive technologies. It had a renaissance of biochemical characterisation, followed by a classical period when sequences were defined and catalytic activity identified. It is now very much under the influence of the structural school. Thus, in many ways its history parallels that of painti作者: 協(xié)奏曲 時間: 2025-3-24 07:47 作者: Ischemia 時間: 2025-3-24 12:25 作者: 使激動 時間: 2025-3-24 18:14
Cas clinique: ?fistule de Crohn? and functional forms Since either genetic inactivation or chemical inhibition of the protease results in the production of non-infectious viral particles, the development of inhibitors of the HIV-1 protease has been pursued as a means of preventing viral replication. Although many inhibitors now ex作者: Misgiving 時間: 2025-3-24 19:41
Fistules anales: le traitement standards is via a blood-sucking insect. Equine infectious anaemia virus (EIAV) is closely related to other lentiviruses of ruminants and primates, such as HIV, SIV and FIV (feline immunodeficiency virus). Just as with these other viruses, EIAV encodes an aspartic proteinase which is essential for processin作者: IDEAS 時間: 2025-3-25 01:48
Fistules anales: le traitement standardle of the virus. The great potential of HIV protease as a therapeutic target for treating the acquired immunodeficiency syndrome, AIDS, has now been confirmed by the recent success of HIV inhibitor drugs to suppress HIV propagation in clinical trials (Ho ., 1995; Wei .., 1995; Coffin, 1995). In spit作者: 散開 時間: 2025-3-25 05:10 作者: decipher 時間: 2025-3-25 08:40
Energy Consumption II—Heat Production and enzymes for the mature virus. Hence, it is essential for the maturation and infectivity of the virus and is thus a major target for the development of inhibitor drugs. But these efforts have been handicapped by the development of drug resistant viral strains.作者: RAGE 時間: 2025-3-25 12:58 作者: BUMP 時間: 2025-3-25 17:33
https://doi.org/10.1007/978-3-658-03521-1ere raised . by passage of HIV-1. in the presence of increasing concentrations of VX-478 and the related hydroxyethylamino sulfonamide inhibitor VB-11,328. By direct PCR analysis of selected viruses, a number of mutations were identified (L10F, M46I,147V, I50V and I84V) in the protease gene. These m作者: debacle 時間: 2025-3-25 23:24 作者: 粗魯?shù)娜?nbsp; 時間: 2025-3-26 03:47
https://doi.org/10.1007/978-3-658-12181-5us uses for the cleavage of the . and . complex during viral replication.. Many research laboratories have developed HIV-1 PR inhibitors that have become lead compounds for anti-viral drugs. Some of these compounds have been found to stop very effectively the replication of the HIV-1 virus ... Howev作者: Memorial 時間: 2025-3-26 04:46
Vertrieb: Der Schwanz wackelt mit dem Hund,gands can interfere with their catalytic properties. The viral proteinase is responsible for processing of viral polyproteins and is essential for viral particle maturation. Inhibition of the proteinase is therefore an efficient means of preventing viral replication, a principle that is used by the 作者: tendinitis 時間: 2025-3-26 08:39
Der gewisse Kniff bei Aktienfonds,hesus monkey ... Infection of macaque species with M-PMV causes an AIDS-like disease.. M-PMV is characterized by the self-assembly of the Gag, Gag-Pro and Gag-Pro-Pol precursors into intracytoplasmic particles (procapsids) within the infected cell cytoplasm. These morphogenetic properties of the vir作者: 確定的事 時間: 2025-3-26 15:39
https://doi.org/10.1007/978-3-663-10073-7fect cattle in which it induces a disease complex termed enzootic bovine leukosis. Experimental infection of rabbits, however, causes severe depression in. immune function.. Although BLV and HTLV are grouped with C-type oncoviruses, during assembly they can be barely distinguished from lentiviruses,作者: 男生戴手銬 時間: 2025-3-26 18:25 作者: Accede 時間: 2025-3-26 21:20 作者: savage 時間: 2025-3-27 02:01
https://doi.org/10.1007/978-1-4615-5373-1Mammalia; apoptosis; enzymes; plant; protein作者: Sedative 時間: 2025-3-27 07:45
978-1-4613-7452-7The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines作者: grenade 時間: 2025-3-27 11:35 作者: Compatriot 時間: 2025-3-27 14:03
X-Ray Crystallographic Studies of the Structure-Function Relationships of HIV-1 Protease and enzymes for the mature virus. Hence, it is essential for the maturation and infectivity of the virus and is thus a major target for the development of inhibitor drugs. But these efforts have been handicapped by the development of drug resistant viral strains.作者: HOWL 時間: 2025-3-27 18:52
Analysis of Autoprocessing of Mason-Pfizer Monkey Virus Proteinase ,hesus monkey ... Infection of macaque species with M-PMV causes an AIDS-like disease.. M-PMV is characterized by the self-assembly of the Gag, Gag-Pro and Gag-Pro-Pol precursors into intracytoplasmic particles (procapsids) within the infected cell cytoplasm. These morphogenetic properties of the virus are typical for D-type retrovirus..作者: 細胞膜 時間: 2025-3-28 01:33 作者: Obstruction 時間: 2025-3-28 02:14 作者: 大看臺 時間: 2025-3-28 10:20 作者: Asseverate 時間: 2025-3-28 11:36
Energy Consumption II—Heat Production and enzymes for the mature virus. Hence, it is essential for the maturation and infectivity of the virus and is thus a major target for the development of inhibitor drugs. But these efforts have been handicapped by the development of drug resistant viral strains.作者: 克制 時間: 2025-3-28 18:31 作者: 里程碑 時間: 2025-3-28 22:41 作者: Senescent 時間: 2025-3-28 23:28 作者: fluoroscopy 時間: 2025-3-29 06:13
The Aspartic Proteinasesmewhat primitive technologies. It had a renaissance of biochemical characterisation, followed by a classical period when sequences were defined and catalytic activity identified. It is now very much under the influence of the structural school. Thus, in many ways its history parallels that of painti作者: AVERT 時間: 2025-3-29 09:19 作者: malapropism 時間: 2025-3-29 12:26
A Cellular Anti-Apoptosis Protein is Cleaved by the HIV-1 Proteasetive protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and programmed death of the host cell. A strategy is proposed to suppress HIV with non-cleavable mutants of bcl-2.作者: 朦朧 時間: 2025-3-29 17:48 作者: 大包裹 時間: 2025-3-29 20:57 作者: mosque 時間: 2025-3-30 02:42 作者: GROWL 時間: 2025-3-30 07:24
A Comparison of , Precursor Cleavage in Naturally Arising HIV Variantsues to be an important consideration in protease inhibitor therapy. Mutations in protease which lead to resistance have been observed in both inhibitor treated and untreated individuals (Borman et al., 1996; Condra et al., 1995). Variations have also been observed to a higher degree in areas of the 作者: Corporeal 時間: 2025-3-30 11:34
X-Ray Crystallographic Studies of the Structure-Function Relationships of HIV-1 Protease and enzymes for the mature virus. Hence, it is essential for the maturation and infectivity of the virus and is thus a major target for the development of inhibitor drugs. But these efforts have been handicapped by the development of drug resistant viral strains.作者: ESO 時間: 2025-3-30 13:48
Optimization of a Macromolecular Inhibitor of HIV-1 Proteaseave been developed. However, there are numerous ways in which a drug can lose effectiveness during long-term therapy. In particular several protease-mediated mechanisms result in reduced antiviral sensitivity of the various anti HIV protease inhibitors. As with inhibitors of reverse transcriptase, p作者: 檔案 時間: 2025-3-30 19:09 作者: B-cell 時間: 2025-3-30 22:13 作者: encomiast 時間: 2025-3-31 01:42 作者: 共同時代 時間: 2025-3-31 05:44
Investigation of an Allosteric Site of HIV-1 Proteinase Involved in Inhibition by Cu2+gands can interfere with their catalytic properties. The viral proteinase is responsible for processing of viral polyproteins and is essential for viral particle maturation. Inhibition of the proteinase is therefore an efficient means of preventing viral replication, a principle that is used by the 作者: faction 時間: 2025-3-31 09:50 作者: 引水渠 時間: 2025-3-31 16:39 作者: opprobrious 時間: 2025-3-31 21:04
Mechanism of Action of Aspartic Proteasesspective specific substrates produce in every case practically identical unstable electronic systems which include catalytic groups of the active center, a cleaved peptide bond and a water molecule. The idea of a similar mutual orientation of these components in all nonbonded complexes of aspartic p作者: 厭食癥 時間: 2025-4-1 00:34
Theory and Method of a Priori Computation of Catalytic Acts of Aspartic and Serine Proteinases, that dynamic conformational properties of a polypeptide chain, manifesting in the folding process cannot be described using current ideas of classical equilibrium thermodynamics. Novel principles of non-linear nonequilibrium thermodynamics (Prigogine physics) have been introduced, giving for the f作者: 油氈 時間: 2025-4-1 04:00
Fistules anales: le traitement standardwas important to establish whether any of these might be effective against EIAV PR. Since no effective treatment currently exists for affected horses, this might be a useful approach for management of this wasting disease.
