作者: Awning 時間: 2025-3-21 22:49 作者: 雜色 時間: 2025-3-22 02:11 作者: neolith 時間: 2025-3-22 05:33
Repetitive Administration of Hemoglobin Raffimer in Experimental Models and Clinical Applications,ose. Hb-raffimer appears to be free of severe toxicity, as shown in a variety of topload/repeat dose preclinical animal studies. In addition, Hbraffimer does not appear to be immunogenic. Limited information is available on the acute and chronic effects of high volume infusion in animals and on resp作者: 小口啜飲 時間: 2025-3-22 12:02
Oxygen Gradients In Vivo Seen by a High Oxygen Affinity HB Polymer,how that carriers with oxygen affinity higher than blood would best deliver oxygen to tissues, although good delivery is produced within a large range of affinities. We tested this hypothesis using a solution of either a high oxygen affinity polymer (ZL-HbBv, P50 = 4mmHg) or of sebacoyl crosslinked 作者: foliage 時間: 2025-3-22 12:56 作者: 語源學(xué) 時間: 2025-3-22 20:02 作者: 誘導(dǎo) 時間: 2025-3-22 22:23
The Development of a Second-Generation, Designer, Recombinant Hemoglobin, to hemoglobin contained within a red blood cell. Numerous issues have been raised with their experimental use such as pulmonary and systemic vasoactivity, extravasation of hemoglobin, serum enzyme increases, adverse effects on gastrointestinal motility, generation of myocardial lesions, and potenti作者: amyloid 時間: 2025-3-23 01:52 作者: 管理員 時間: 2025-3-23 09:29 作者: 音的強弱 時間: 2025-3-23 10:27 作者: GRATE 時間: 2025-3-23 17:39
New Strategy for the Preparation of NO-Treated Red Blood Cells as a Blood Substitute,ric oxide (NO) [Yonetani et al., (1998) J Biol Chem 273: 20323], have shown that the α-nitrosyl HbA is a cooperative, low-affinity oxygen carrier. We have developed a simple method to convert all the intra-human red blood cells (RBCs) to a 50% saturation of hemes with NO exclusively bound to the α-s作者: euphoria 時間: 2025-3-23 21:10
Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme,-heme, is an entirely synthetic hemoprotein that can reversibly bind and release O. under physiological conditions. We have recently found that replacing the substituent groups of FepivP with more hydrophobic 1-methylcyclohexanoylamino groups, affording FecycP, substantially stabilizes the formed O.作者: 欺騙世家 時間: 2025-3-24 01:46 作者: 抗原 時間: 2025-3-24 03:47 作者: 共同生活 時間: 2025-3-24 10:32 作者: DOLT 時間: 2025-3-24 14:44 作者: 茁壯成長 時間: 2025-3-24 15:56 作者: 遷移 時間: 2025-3-24 20:22
https://doi.org/10.1007/978-1-4939-7113-8p50 in humans is scant. In the case of cell-free hemoglobin, the mechanisms of O. transfer to tissue are completely different, such that unless p50 is significantly reduced, O. oversupply will result, engaging autoregulatory mechanisms that leads to vasoconstriction. A second generation of O. carrie作者: esoteric 時間: 2025-3-25 00:26
Tianfa Xie,Jamar Hawkins,Yubing Sun In rabbit jejunum membranes, superfused under hypoxic conditions, the presence of the DECA allowed metabolites transport across the mucosa. Equivalent suspensions of red cells failed to allow transport. It is suggested that non-extravasating HBOC with high oxygen affinity can still deliver oxygen t作者: harangue 時間: 2025-3-25 06:19 作者: extrovert 時間: 2025-3-25 10:00
Ralf Weiskirchen,Axel M. Gressnerrties of Hb [1–8]. Therefore, it was not surprising that the commercial development of HemAssist, a diaspirin αα-cross-linked human Hb, (Baxter Healthcare, Round Lake, IL, USA) was halted, and the development of Hemolink, a .-raffinose polymerized human Hb, (Hemosol, Mississauga, Canada) was paused 作者: tariff 時間: 2025-3-25 15:14 作者: Apoptosis 時間: 2025-3-25 16:12 作者: FLAGR 時間: 2025-3-25 20:35
Merry L. Lindsey,Lisandra E. de Castro BráscycP. Laser-flash photolysis experiments gave the association and dissociation rate constants for O. and CO (., .). The rebinding kinetics of these gaseous ligands consists of multiple exponentials. We conjectured that the O.- and CO-binding reactions are affected by the molecular environment around作者: ALB 時間: 2025-3-26 00:21 作者: Neuralgia 時間: 2025-3-26 06:09
Antonio Di Sabatino,Paolo Giuffrida0.14μm for Perftoran. The main oxygen-independent properties of Perftoran are the following: a decrease in rigidity of heart muscle during cardioplegia due to a reversible inhibition of Ca-current and a decrease in its sensitivity to epinephrine; immunosuppressive effect is connected with the inhibi作者: Asperity 時間: 2025-3-26 11:42
Isolation of Nanofibrils from Animal Silks in the emulsion. For fluorocarbon emulsions, small droplet sizes translate into prolonged intravascular persistence and reduced side effects. FnHm diblocks thus provide a useful, versatile tool to improve the characteristics and stability of injectable fluorocarbon emulsions.作者: 內(nèi)閣 時間: 2025-3-26 13:36 作者: Isthmus 時間: 2025-3-26 19:32 作者: 沙漠 時間: 2025-3-27 00:47 作者: Volatile-Oils 時間: 2025-3-27 01:59 作者: insular 時間: 2025-3-27 09:03
Effect of Hemoglobin-Based Blood Substitutes on Nitric Oxide Transport: Mathematical Models,te effect of wall shear stress. The predicted NO concentration falls several-fold from its physiological level when HBOC is introduced. We analyzed the transport resistance in and around the red blood cell since it is a determining factor on the luminal NO consumption. Using similar approach, we als作者: Monolithic 時間: 2025-3-27 13:03 作者: NUDGE 時間: 2025-3-27 17:13 作者: antipsychotic 時間: 2025-3-27 18:06 作者: FUSE 時間: 2025-3-28 00:43 作者: nettle 時間: 2025-3-28 05:34
Semifluorinated Alkanes as Stabilizing Agents of Fluorocarbon Emulsions, in the emulsion. For fluorocarbon emulsions, small droplet sizes translate into prolonged intravascular persistence and reduced side effects. FnHm diblocks thus provide a useful, versatile tool to improve the characteristics and stability of injectable fluorocarbon emulsions.作者: jaundiced 時間: 2025-3-28 07:34 作者: 追蹤 時間: 2025-3-28 11:45 作者: eczema 時間: 2025-3-28 17:09 作者: 連累 時間: 2025-3-28 20:41
Isolation and Culture of Skin Fibroblastsing a hemoglobin (Hb)-based oxygen carrier. In this chapter, we have summarized the characteristics and performances of Hb-vesicles (HbV) that have been developed on the basis of molecular assembly. Collaborative in vitro and in vivo studies have revealed sufficient safety and efficacy of HbV.作者: Mercurial 時間: 2025-3-28 23:46 作者: dilute 時間: 2025-3-29 04:19 作者: Bucket 時間: 2025-3-29 07:23
978-4-431-54636-8Springer-Verlag Tokyo 2005作者: flimsy 時間: 2025-3-29 12:24
Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes,s have been selected from the viewpoints of safety, efficacy, and cost performance. One is Hemoglobin-vesicles (HbV) and the other is albumin-heme (rHSA-heme). This chapter summarizes our video presentation that introduced the recent results of our research into HbV and rHSA-heme.作者: 連累 時間: 2025-3-29 18:35
Hemoglobin-Vesicles (HbV) as Artificial Oxygen Carriers,ing a hemoglobin (Hb)-based oxygen carrier. In this chapter, we have summarized the characteristics and performances of Hb-vesicles (HbV) that have been developed on the basis of molecular assembly. Collaborative in vitro and in vivo studies have revealed sufficient safety and efficacy of HbV.作者: Expediency 時間: 2025-3-29 22:17
Intravascular Microbubbles: An Ultra-Effective Means of Transporting Oxygen,able to transport physiologically significant amounts of oxygen in animal experiments. Thus, the treatment sustained life in rats and pigs with potentially fatal erythrocytopenia caused by hemorrhage and hemodilution, and adequate oxygenation was preserved in severe right-to-left circulatory shunts caused by partial airway blockage in pigs.作者: 窗簾等 時間: 2025-3-29 23:57 作者: 不透氣 時間: 2025-3-30 06:44 作者: 存在主義 時間: 2025-3-30 09:47 作者: 或者發(fā)神韻 時間: 2025-3-30 13:16 作者: 漫不經(jīng)心 時間: 2025-3-30 19:48
Fibromyalgie und Selbstwirksamkeits have been selected from the viewpoints of safety, efficacy, and cost performance. One is Hemoglobin-vesicles (HbV) and the other is albumin-heme (rHSA-heme). This chapter summarizes our video presentation that introduced the recent results of our research into HbV and rHSA-heme.作者: 燒烤 時間: 2025-3-30 23:59
Methods for Identification of Fibronectins,fluorochemicals are chemical oxygen carriers that are being actively developed with some in the advanced stages of clinical trials. Meanwhile, new generations of modified Hb are being developed that can modulate the effects of nitric oxide. Other systems are also being developed to include antioxida作者: 全面 時間: 2025-3-31 01:23
https://doi.org/10.1007/978-1-4939-7113-80 is an important determinant of O. delivery. This assumption is based on antiquated measurements in subjects exposed to hypoxia, for whom a theory was developed that an increase in red cell 2,3-DPG shifts the oxygen equilibrium curve to the right (high p50, low O. affinity), thereby providing “adap作者: certain 時間: 2025-3-31 07:53 作者: 水槽 時間: 2025-3-31 13:08
Tianfa Xie,Jamar Hawkins,Yubing Sunhow that carriers with oxygen affinity higher than blood would best deliver oxygen to tissues, although good delivery is produced within a large range of affinities. We tested this hypothesis using a solution of either a high oxygen affinity polymer (ZL-HbBv, P50 = 4mmHg) or of sebacoyl crosslinked 作者: 一大群 時間: 2025-3-31 13:50
John Varga,David A. Brenner,Sem H. Phanf the circulating blood and the vasoactivity induced to the restore normal distribution of pO.. Vasoactivity has an oxygen cost shown by the oxygen consumption of the arteriolar microcirculation. Vasodilators lower arteriolar oxygen consumption delivering more oxygen to the tissues, and vice versa. 作者: 羽毛長成 時間: 2025-3-31 18:53 作者: 我沒有強迫 時間: 2025-4-1 01:16
https://doi.org/10.1385/1592599400 to hemoglobin contained within a red blood cell. Numerous issues have been raised with their experimental use such as pulmonary and systemic vasoactivity, extravasation of hemoglobin, serum enzyme increases, adverse effects on gastrointestinal motility, generation of myocardial lesions, and potenti作者: contrast-medium 時間: 2025-4-1 01:55
Isolation and Culture of Skin Fibroblastsing a hemoglobin (Hb)-based oxygen carrier. In this chapter, we have summarized the characteristics and performances of Hb-vesicles (HbV) that have been developed on the basis of molecular assembly. Collaborative in vitro and in vivo studies have revealed sufficient safety and efficacy of HbV.作者: ACME 時間: 2025-4-1 09:28 作者: dissolution 時間: 2025-4-1 12:55 作者: ETCH 時間: 2025-4-1 15:32
https://doi.org/10.1007/978-3-319-98143-7ric oxide (NO) [Yonetani et al., (1998) J Biol Chem 273: 20323], have shown that the α-nitrosyl HbA is a cooperative, low-affinity oxygen carrier. We have developed a simple method to convert all the intra-human red blood cells (RBCs) to a 50% saturation of hemes with NO exclusively bound to the α-s作者: anaphylaxis 時間: 2025-4-1 19:37
Merry L. Lindsey,Lisandra E. de Castro Brás-heme, is an entirely synthetic hemoprotein that can reversibly bind and release O. under physiological conditions. We have recently found that replacing the substituent groups of FepivP with more hydrophobic 1-methylcyclohexanoylamino groups, affording FecycP, substantially stabilizes the formed O.
