標(biāo)題: Titlebook: Artificial Nucleases; Marina A. Zenkova Book 2004 Springer-Verlag Berlin Heidelberg 2004 Catalysis.Cleavage.Conjugates.DNA.Enzyme mimics.N [打印本頁(yè)] 作者: 無法生存 時(shí)間: 2025-3-21 19:39
書目名稱Artificial Nucleases影響因子(影響力)
書目名稱Artificial Nucleases影響因子(影響力)學(xué)科排名
書目名稱Artificial Nucleases網(wǎng)絡(luò)公開度
書目名稱Artificial Nucleases網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Artificial Nucleases被引頻次
書目名稱Artificial Nucleases被引頻次學(xué)科排名
書目名稱Artificial Nucleases年度引用
書目名稱Artificial Nucleases年度引用學(xué)科排名
書目名稱Artificial Nucleases讀者反饋
書目名稱Artificial Nucleases讀者反饋學(xué)科排名
作者: dandruff 時(shí)間: 2025-3-21 20:56
Günther Schlag,Peter B?sch,Helene Matraser natural ribonucleases such as: higher RNA sequence cleavage specificity, sequence flexibility in designing the site of RNA cleavage, and a wider range of conditions at which artificial ribonucleases are functional (Komiyama et al. 2001).作者: 一回合 時(shí)間: 2025-3-22 04:00 作者: NIL 時(shí)間: 2025-3-22 08:09 作者: Vasoconstrictor 時(shí)間: 2025-3-22 10:29
Site-Specific Artificial Ribonucleases: Conjugates of Oligonucleotides with Catalytic Groups,998; Sil’nikov and Vlassov 2001). Apart from being useful molecular biology tools (Hüber 1993; Giegé et aL 2000), such compounds may provide new opportunities for design of therapeutics targeting specific messenger RNAs and viral genomic RNAs (Uhlmann and Peymann 1990; Komyiama and Sumaoka 1998; Trawick et aL 1998; Crook et aL 2000).作者: BAIT 時(shí)間: 2025-3-22 15:13
https://doi.org/10.1007/978-3-642-18510-6Catalysis; Cleavage; Conjugates; DNA; Enzyme mimics; Nucleotide; RNA; biotechnology; enzymes; biochemical eng作者: 吹牛需要藝術(shù) 時(shí)間: 2025-3-22 17:19 作者: 橢圓 時(shí)間: 2025-3-22 21:19 作者: Glower 時(shí)間: 2025-3-23 05:13
Y. Moazami-Goudarzi,C. Khodadadyanled as nucleotide units, joined together by phosphate diester links. Given the need to permanently retain genetic information, it is not surprising that the phosphate diester is far more kinetically stable than other common biological functional groups such as amides or esters (Westheimer 1987). How作者: 浪費(fèi)時(shí)間 時(shí)間: 2025-3-23 06:18 作者: vibrant 時(shí)間: 2025-3-23 13:36
Günther Schlag,Peter B?sch,Helene Matraser natural ribonucleases such as: higher RNA sequence cleavage specificity, sequence flexibility in designing the site of RNA cleavage, and a wider range of conditions at which artificial ribonucleases are functional (Komiyama et al. 2001).作者: CONE 時(shí)間: 2025-3-23 15:11
P. G. Friedl,G. Schürmann,Ch. Herfarthtions in biotechnology, for manipulating RNA, and in drug design. A direct approach to design of artificial RNases consists in imitation of the active centers of natural enzymes by simple organic structures possessing minimal sets of the most important characteristics that are essential for catalysi作者: 革新 時(shí)間: 2025-3-23 20:52
https://doi.org/10.1007/978-3-642-85101-8to behave as salts in solution since the negative charges of the polynucleotide phosphodiester backbone are usually neutralized by metal solute ions. Therefore, for practical purposes, it is difficult if not impossible to separate the behavior of DNA and RNA from their interactions with metal ions. 作者: BILK 時(shí)間: 2025-3-24 00:52 作者: phase-2-enzyme 時(shí)間: 2025-3-24 04:24
G. Spilker,R. Türk,A. Stemberger,G. Blümelcid is reflected in a number of reviews (Strater et al. 1996; Wilcox 1996; Cowan 1998; Kovall and Matthews 1999). In enzymes, interactions between functional groups of amino acid side radicals result in complex tertiary and quaternary structures that determine the composition of different functional作者: 變化無常 時(shí)間: 2025-3-24 08:13
https://doi.org/10.1007/978-3-642-69655-8f magnesium ion predominates in natural nucleolytic enzymes owing to high abundance of these ions, redox inertness, ligand exchange rates and charge density. However, other metal ions and multinuclear metal centers have also been identified in phosphate ester hydrolase enzymes with Zn.,Fe. and Ca. (作者: musicologist 時(shí)間: 2025-3-24 10:56
Milzklebung im Kleintierversuch ohne Vliesonal groups of amino acid residues from catalytic centers of natural RNases: conjugates containing imidazole and carboxylate ions, guanidinium groups (see review Silnikov and Vlassov 200l). This chapter is devoted to proteins displaying ribonuclease activity and peptide-based conjugates which are ca作者: V切開 時(shí)間: 2025-3-24 16:49
B. Kessler,M. Arndt,R. E. Zimmermann If only one RNA can be chosen from many other RNAs and selectively cleaved at the desired site, it opens the way to new RNA science (regulation of expression of a specific gene in cells, advanced therapy, RNA manipulation, and others). However, none of the naturally occurring ribonucleases shows su作者: correspondent 時(shí)間: 2025-3-24 20:09
Milzklebung im Kleintierversuch ohne Vlies998; Sil’nikov and Vlassov 2001). Apart from being useful molecular biology tools (Hüber 1993; Giegé et aL 2000), such compounds may provide new opportunities for design of therapeutics targeting specific messenger RNAs and viral genomic RNAs (Uhlmann and Peymann 1990; Komyiama and Sumaoka 1998; Tra作者: 傳授知識(shí) 時(shí)間: 2025-3-25 02:23 作者: 即席演說 時(shí)間: 2025-3-25 03:51 作者: 健談 時(shí)間: 2025-3-25 11:03
V. Lange,G. Meyer,H. Rau,A. Mewesgested more than 30 years ago (Belikova et al. 1967). Since then, various oligonucleotide derivatives have been created which are capable of damaging nucleic acids and thereby influencing their function (Knorre et al. 1994). However, such oligonucleotide conjugates have not yet been applied as artif作者: 煩擾 時(shí)間: 2025-3-25 12:44 作者: Dna262 時(shí)間: 2025-3-25 18:43
Nucleic Acids and Molecular Biologyhttp://image.papertrans.cn/b/image/162708.jpg作者: custody 時(shí)間: 2025-3-25 22:19
P. G. Friedl,G. Schürmann,Ch. Herfarthles. This simplicity appears to be an advantage when artificial RNases are used in design of therapeutics for controlling gene expression or as components of synthetic conjugates. These conjugates are targeted to specific RNA molecules by oligonucleotides, and unwanted interactions of their componen作者: 接觸 時(shí)間: 2025-3-26 03:53 作者: Crumple 時(shí)間: 2025-3-26 05:34 作者: 瘙癢 時(shí)間: 2025-3-26 11:21 作者: ALERT 時(shí)間: 2025-3-26 13:45
V. Lange,G. Meyer,H. Rau,A. Mewes footprinting experiments to analyze the structure of protein-nucleic acid complexes. These cleavage reagents have also been tethered to larger molecules such as oligonucleotides, proteins, and intercalating agents, which confer additional specificity. This review will focus on the 1,1O-phenanthroli作者: 社團(tuán) 時(shí)間: 2025-3-26 17:50
0933-1891 s. The second class, artificial nucleases, are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets o978-3-642-62139-0978-3-642-18510-6Series ISSN 0933-1891 Series E-ISSN 1869-2486 作者: AIL 時(shí)間: 2025-3-26 21:48
Book 2004nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents. The second class, artificial nucleases, are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets o作者: Suggestions 時(shí)間: 2025-3-27 03:53
Cleavage of RNA by Imidazole,les. This simplicity appears to be an advantage when artificial RNases are used in design of therapeutics for controlling gene expression or as components of synthetic conjugates. These conjugates are targeted to specific RNA molecules by oligonucleotides, and unwanted interactions of their componen作者: granite 時(shí)間: 2025-3-27 07:08
Allosterically Controlled Ribozymes as Artificial Ribonucleases,fic sequences of interest, as therapeutic agents and as specific regulators of gene expression (Cech 1988; Yu et al. 1995; Bertrand et al. 1997; Birikh et al. 1997; Kawasaki et al. 1998; Lan et al. 1998; Plehn-Dujowich and Altman 1998; Kuwabara et al. 1998a,b, 1999; Koseki et al. 1999; Warashina et 作者: 案發(fā)地點(diǎn) 時(shí)間: 2025-3-27 11:37
Small Ribonuclease Mimics,8; Kozlowski et al. 1999; Kimura 2000). For nucleic acids cleaving enzymes it is suggested that hydrolysis of p-o bonds passes via acid-base catalysis (delCardayre and Raines 1995). In contrast to hydrolysis of c-o bonds, the p-o bonds are very rarely cleaved via nucleophilic catalysis (Gottlin et a作者: Munificent 時(shí)間: 2025-3-27 14:49
Copper Containing Nuclease Mimics: Synthetic Models and Biochemical Applications,is proposed to have a trinuclear Zn. coordination (Shishido and Habuka 1986); . endonuclease displays Mg.-dependent nucleolytic activity, where metal ion is used to reduce the activation energy of P-O bond fission (Miller and Krause 1996).作者: FRET 時(shí)間: 2025-3-27 18:44
DNA and RNA Cleavage Mediated by Phenanthroline-Cuprous Oligonucleotides: From Properties to Applic footprinting experiments to analyze the structure of protein-nucleic acid complexes. These cleavage reagents have also been tethered to larger molecules such as oligonucleotides, proteins, and intercalating agents, which confer additional specificity. This review will focus on the 1,1O-phenanthroli作者: PLUMP 時(shí)間: 2025-3-27 23:11 作者: Stress 時(shí)間: 2025-3-28 04:01
RNA-Cleaving Oligonucleotide-Peptide Conjugates,pable of hydrolyzing RNA. The basic requirements showed by any artificial ribonucleases are high efficiency and specificity of RNA cleavage. The efficiency of hydrolysis is determined by the catalytic properties of active groups, and the specificity is determined by the affinity of compounds for certain RNA sites.作者: 使人煩燥 時(shí)間: 2025-3-28 07:13 作者: 有害 時(shí)間: 2025-3-28 14:02 作者: 大吃大喝 時(shí)間: 2025-3-28 17:02
Book 2004immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology. There are essentially two classes of these agents - nucleases that occur naturally inside cells and synthetically produced artificial nucleases. The first class includes protein enzyme n作者: 喚醒 時(shí)間: 2025-3-28 20:20
Hemangioma Treatment with Fibrin Sealantms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents.作者: 桶去微染 時(shí)間: 2025-3-29 02:43
Y. Moazami-Goudarzi,C. Khodadadyang elimination of phosphate (and destroying one of the nucleotide units). The purpose of this brief review is to summarise the mechanisms relevant to DNA hydrolysis and in particular to estimate the rate of hydrolysis through attack at the phosphate diester under mild, aqueous conditions.作者: majestic 時(shí)間: 2025-3-29 05:12 作者: 前奏曲 時(shí)間: 2025-3-29 09:41
Introduction,ms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents.作者: 極為憤怒 時(shí)間: 2025-3-29 12:30 作者: 發(fā)怨言 時(shí)間: 2025-3-29 16:40
Principles of Nucleic Acid Cleavage by Metal Ions,than the properties of nucleic acids due to their smaller size. In fact, both nucleic acids and metal ions exhibit considerable complexity in their interactions, and such interactions could affect the chemical and biochemical properties of both parties.作者: Overthrow 時(shí)間: 2025-3-29 23:16 作者: HALL 時(shí)間: 2025-3-30 03:27 作者: MANIA 時(shí)間: 2025-3-30 06:55
Sequence Selective Artificial Ribonucleases Employing Metal Ions As Scissors,pression of a specific gene in cells, advanced therapy, RNA manipulation, and others). However, none of the naturally occurring ribonucleases shows such a high sequence-selectivity. This is why sequence-selective artificial ribonucleases are desirable.作者: exigent 時(shí)間: 2025-3-30 09:14
P. L. Melanotte,F. Marconi,E. Tellatin been the object of landmark work in protein chemistry and enzymology (see Cuchillo et al. 1997; Raines 1998 and references therein). In addition, cytotoxic RNase A variants and homologues have demonstrated utility as chemotherapeutic agents (Leland and Raines 2001).作者: ascend 時(shí)間: 2025-3-30 13:38 作者: oxidize 時(shí)間: 2025-3-30 19:33 作者: 大約冬季 時(shí)間: 2025-3-30 23:44
V. Lange,G. Meyer,H. Rau,A. Mewesicial nucleases in either scientific or medical practice. A number of drawbacks hampering a wide application of these oligonucleotide derivatives have been revealed and not yet overcome. One of these drawbacks is insufficient interaction efficiency with a target NA; another, a low selectivity of this interaction.
