作者: 仔細檢查 時間: 2025-3-22 00:12
https://doi.org/10.1007/978-3-031-51471-5experimental hypoxia changes the respiratory pattern, which correlates with increased sympathetic activity and may explain the hypertension observed in male and female rats previously submitted to CIH or SH.作者: 猛然一拉 時間: 2025-3-22 01:46 作者: LANCE 時間: 2025-3-22 06:52
e-Learning, e-Education, and Online Trainingatecholamine concentrations. Acute?β.-adrenoceptor inhibition reduced contractility in CIH-exposed animals (?7604?±?1298 vs. ?4747?±?2080?mmHg/s; .?=?0.014), to levels equivalent to control, while preserving cardiovascular parameters. Sympathetic ganglion blockade (hexamethonium 25?mg/kg; i.v.) prod作者: 人類 時間: 2025-3-22 10:02
e-Learning, e-Education, and Online Trainingand 2-APB-treated rats. We found correlations between RVSP and increased medial layer and STOC pulmonary levels. 2-APB-treated rats showed a correlation between RVSP and the medial layer thickness, α-actin-ir, and STOC, whereas RVSP did not correlate with MDA levels in CIH and 2-APB-treated rats. CI作者: 發(fā)現(xiàn) 時間: 2025-3-22 14:18 作者: flimsy 時間: 2025-3-22 19:39 作者: 有組織 時間: 2025-3-23 00:49
https://doi.org/10.1007/978-3-031-51503-3wing termination of AIH..In . mice, ventilation was significantly increased 60 min post-AIH compared to baseline. However, metabolic CO. production was also increased. Therefore, ventilatory equivalent was unaffected by AIH exposure, i.e., no ventilatory LTF manifestation. In wild-type mice, ventila作者: Parley 時間: 2025-3-23 01:36 作者: FRAUD 時間: 2025-3-23 08:46
Cong Li,Yuan Zhou,Chengjie Li,Jun Liumarkably, all these were closely linked to the enhanced CB-mediated chemoreflex drive. Our results showed that mice with CHD displayed an enhanced CB chemoreflex, sympathoexcitation, and disordered breathing and suggest that CBs may be involved in chronic cardiorespiratory alterations in the setting作者: Organonitrile 時間: 2025-3-23 11:00 作者: ethereal 時間: 2025-3-23 16:15 作者: affect 時間: 2025-3-23 21:43
Cong Li,Yuan Zhou,Chengjie Li,Jun LiuIndeed, R., Cd., and EEW values in CBD mice were undistinguishable from the ones obtained in sham mice. Finally, we found that CBD induces lung parenchyma morphological alterations characterized by reduced alveoli space. Together our results showed that CBD progressively increases lung resistance at作者: 惰性女人 時間: 2025-3-23 23:16 作者: Heart-Rate 時間: 2025-3-24 02:54 作者: 無法解釋 時間: 2025-3-24 06:39 作者: 懲罰 時間: 2025-3-24 14:08 作者: 不透明性 時間: 2025-3-24 15:53 作者: 暫時中止 時間: 2025-3-24 19:04 作者: 紡織品 時間: 2025-3-24 23:18 作者: Immortal 時間: 2025-3-25 03:39
Control of Arterial Hypertension by the AhR Blocker CH-223191: A Chronopharmacological Study in Chrevels..Despite drug administration before starting the inactive period of the animals, CH-223191 was not able to decrease BP during the inactive phase, in CIH conditions, therefore not reverting the non-dipping profile. These results suggest that a higher dose or different time of administration of 作者: 無節(jié)奏 時間: 2025-3-25 08:49 作者: nonchalance 時間: 2025-3-25 12:29
The Beneficial Effect of the Blockade of Stim-Activated TRPC-ORAI Channels on Vascular Remodeling aand 2-APB-treated rats. We found correlations between RVSP and increased medial layer and STOC pulmonary levels. 2-APB-treated rats showed a correlation between RVSP and the medial layer thickness, α-actin-ir, and STOC, whereas RVSP did not correlate with MDA levels in CIH and 2-APB-treated rats. CI作者: reflection 時間: 2025-3-25 16:34
Intermittent Hypoxia and Weight Loss: Insights into the Etiology of the Sleep Apnea Phenotype,tin, adrenocorticotropic hormone (ACTH), and testosterone levels but increased inflammatory cytokines. We conclude that IH does not replicate the metabolic clinical features of SA patient, thus raising our awareness of the limitations of the IH model. The fact that the risk for hypertension occurs b作者: 六個才偏離 時間: 2025-3-25 21:10 作者: 完成 時間: 2025-3-26 01:00 作者: 牌帶來 時間: 2025-3-26 07:00 作者: ALTER 時間: 2025-3-26 12:25
Enhanced Peripheral Chemoreflex Drive Is Associated with Cardiorespiratory Disorders in Mice with Cmarkably, all these were closely linked to the enhanced CB-mediated chemoreflex drive. Our results showed that mice with CHD displayed an enhanced CB chemoreflex, sympathoexcitation, and disordered breathing and suggest that CBs may be involved in chronic cardiorespiratory alterations in the setting作者: Mets552 時間: 2025-3-26 14:41
Role of Peripheral Chemoreceptors on Enhanced Central Chemoreflex Drive in Nonischemic Heart Failurdingly, we studied central/peripheral chemoreflex drive and breathing disorders in HF rats with and without functional CBs (CB denervation). We found that CB afferent activity was required to increase central chemoreflex drive in HF. Indeed, CB denervation restored normal central chemoreflex drive a作者: Cholecystokinin 時間: 2025-3-26 17:00 作者: 溫和女孩 時間: 2025-3-27 00:35
Contribution of Carotid Bodies on Pulmonary Function During Normoxia and Acute Hypoxia,Indeed, R., Cd., and EEW values in CBD mice were undistinguishable from the ones obtained in sham mice. Finally, we found that CBD induces lung parenchyma morphological alterations characterized by reduced alveoli space. Together our results showed that CBD progressively increases lung resistance at作者: Heart-Attack 時間: 2025-3-27 01:53
Increased Abdominal Perimeter Differently Affects Respiratory Function in Men and Women,ast, when subjects were subdivided based on the abdominal perimeter, a higher circumference did not change the respiratory frequency but induced a decrease in tidal volume and minute ventilation in women, while in men these two parameters increased. In conclusion, higher abdominal circumference rath作者: Interregnum 時間: 2025-3-27 05:25 作者: 感激小女 時間: 2025-3-27 09:54 作者: 高爾夫 時間: 2025-3-27 15:15
Of Mice and Men and Plethysmography Systems: Does LKB1 Determine the Set Point of Carotid Body Chematecholaminergic cells, precipitating hypoventilation and apnea during hypoxia rather than hyperventilation. Moreover, LKB1, but not AMPK, deficiency causes Cheyne-Stokes-like breathing. This chapter will explore further the possible mechanisms that determine these outcomes.作者: phase-2-enzyme 時間: 2025-3-27 18:55 作者: Ringworm 時間: 2025-3-28 01:06
Conference proceedings 2023find new therapeutic targets for treatment and prevention. This book will cover a broad range of topics related, not only with the fundamental knowledge of the mechanisms related with the chemical sensing in the carotid body, but also with the adaptive and mal-adaptive responses of arterial chemorec作者: 變化無常 時間: 2025-3-28 04:06
Conference proceedings 2023) meeting, to be held in Lisbon in Portugal in June/July 2020. Since ISAC was first established, almost 70 years ago, many advances in the classical field of arterial O2, CO2 and pH sensing have been achieved but the most impressive ones are probably related to the non-canonical roles of the carotid作者: VEIL 時間: 2025-3-28 09:21
https://doi.org/10.1007/978-3-031-51471-5pathophysiological remodeling in disease states. Herein, we review this published work that reveals novel molecular mechanisms underpinning multimodal sensing and reveals numerous gaps in knowledge that require experimental testing.作者: 召集 時間: 2025-3-28 10:29
Transcriptomics of the Carotid Body,pathophysiological remodeling in disease states. Herein, we review this published work that reveals novel molecular mechanisms underpinning multimodal sensing and reveals numerous gaps in knowledge that require experimental testing.作者: Confirm 時間: 2025-3-28 17:25
https://doi.org/10.1007/978-3-031-51471-5rstanding of the functioning of this stunning germinal niche will very likely facilitate the management and treatment of an important group of diseases that course with carotid body over-activation and malfunction.作者: 發(fā)酵 時間: 2025-3-28 19:51
The Adult Carotid Body: A Germinal Niche at the Service of Physiology,rstanding of the functioning of this stunning germinal niche will very likely facilitate the management and treatment of an important group of diseases that course with carotid body over-activation and malfunction.作者: Exuberance 時間: 2025-3-28 22:56 作者: correspondent 時間: 2025-3-29 03:23 作者: animated 時間: 2025-3-29 09:22
The Adult Carotid Body: A Germinal Niche at the Service of Physiology,r the organismal adaptation to a maintained hypoxemia. Profound angiogenic and neurogenic processes take place in the carotid body to facilitate this adaptation process. We have described a plethora of multipotent stem cells and restricted progenitors, from both vascular and neuronal lineages, exist作者: 太空 時間: 2025-3-29 13:38
Evidences That Sympathetic Overactivity and Neurogenic Hypertension Correlate with Changes in the Rved in some experimental models of hypoxia? Although there is evidence supporting the concept that sympathetic-respiratory coupling is increased in different models of experimental hypoxia [chronic intermittent hypoxia (CIH) and sustained hypoxia (SH)], it was also observed that in some strains of r作者: 共和國 時間: 2025-3-29 18:57
Control of Arterial Hypertension by the AhR Blocker CH-223191: A Chronopharmacological Study in Chruently display a non-dipping pattern of blood pressure (BP) and resistant HTN. After discovering that AHR-CYP1A1 axis is a druggable target in CIH-HTN, we hypothesized that CH-223191 could control BP in both active and inactive periods of the animals, recovering the BP dipping profile in CIH conditi作者: Arthr- 時間: 2025-3-29 22:48
,Three Days of Chronic Intermittent Hypoxia Induce β1-Adrenoceptor Dependent Increases in Left VentrWe previously demonstrated that exposure to CIH increases cardiac output and sought to determine if enhanced cardiac contractility manifests prior to hypertension..Male Wistar rats were exposed to cyclical bouts of hypoxia (FiO.?=?0.05 nadir; 90?s) and normoxia (FiO.?=?0.21; 210?s) 8?h/day for 3?day作者: 爭論 時間: 2025-3-30 00:40
The Beneficial Effect of the Blockade of Stim-Activated TRPC-ORAI Channels on Vascular Remodeling aH). Rats exposed to CIH develop systemic and lung oxidative stress, pulmonary vascular remodeling, and PH and overexpress Stim-activated TRPC-ORAI channels (STOC) in the lung. Previously, we demonstrated that 2-aminoethyl-diphenylborinate (2-APB)-treatment, a STOC-blocker, prevents PH and the overex作者: Opponent 時間: 2025-3-30 06:21
Intermittent Hypoxia and Weight Loss: Insights into the Etiology of the Sleep Apnea Phenotype,omplex disorder remains limited. Because apneas lead to recurrent drops in O. during sleep, intermittent hypoxia (IH) is the main animal model to explore the pathophysiology of SA. Here, we assessed the impacts of IH on metabolic function and related signals. Adult male rats were exposed to 1?week o作者: 水槽 時間: 2025-3-30 09:29
Effects of Gestational Intermittent Hypoxia on Placental Morphology and Fetal Development in a Muricomes for mother and offspring. Despite a prevalence of 8–20% in pregnant women, this disorder is often underdiagnosed..We have developed a murine model of gestational OSA to study IH effects on pregnant mothers, placentas, fetuses, and offspring. One group of pregnant rats was exposed to IH during 作者: 朋黨派系 時間: 2025-3-30 12:56 作者: 類型 時間: 2025-3-30 20:30 作者: atopic 時間: 2025-3-30 20:57
Enhanced Peripheral Chemoreflex Drive Is Associated with Cardiorespiratory Disorders in Mice with Cnd oxidation within the coronary arteries. Dyslipidemia is associated with local tissue damage by oxidative stress/inflammation and carotid bodies (CB) peripheral chemoreceptors are heavily modulated by both reactive oxygen species and pro-inflammatory molecules (i.e., cytokines). Despite?this,?it i作者: inhumane 時間: 2025-3-31 01:44 作者: extrovert 時間: 2025-3-31 05:55 作者: 分解 時間: 2025-3-31 09:58
Contribution of Carotid Bodies on Pulmonary Function During Normoxia and Acute Hypoxia,ol, the precise contribution of CBs on the regulation of lung mechanics remains controversial. Accordingly, we study changes in lung mechanics in normoxia (FiO. 21%) and hypoxia (FiO. 8%) in mice with or without functional CBs. For this, we used adult male mice that underwent sham or CB denervation 作者: 開始沒有 時間: 2025-3-31 14:11
Increased Abdominal Perimeter Differently Affects Respiratory Function in Men and Women,ight may affect the respiratory system due to fat deposition and systemic inflammation. Herein, we evaluated the sex differences in the impact of obesity and high abdominal circumference on basal ventilation. Thirty-five subjects, 23 women and 12 men with a median age of 61 and 67, respectively, wer作者: grandiose 時間: 2025-3-31 21:36
Carotid Body Resection Prevents Short-Term Spatial Memory Decline in Prediabetic Rats Without Changkinson’s disease. A shared dysfunctional characteristic between T2D and these neurodegenerative disorders is insulin resistance. Recently, it was shown that prediabetes animals and patients exhibited increased carotid body (CB) activity. Moreover, these organs are deeply involved in the development 作者: 法律 時間: 2025-3-31 21:52 作者: ROOF 時間: 2025-4-1 04:57 作者: nonsensical 時間: 2025-4-1 09:27
Analyzing Angiotensin II Receptor Type 1 Clustering in PC12 Cells in Response to Hypoxia Using Dirensitive cells, including carotid body (CB) type I cells and pheochromocytoma 12 (PC12) cells, and Ang II increases cell activity. While a functional role for Ang II and AT.Rs in increasing the activity of O. sensitive cells has been established, the nanoscale distribution of AT.Rs has not. Furthermo作者: otic-capsule 時間: 2025-4-1 12:33
https://doi.org/10.1007/978-3-031-51471-5iseases. In adjunct to its classical role as an arterial O. sensor, the CB is a multimodal sensor activated by a range of stimuli in the circulation. However, consensus on how CB multimodality is achieved is lacking; even the best studied O.-sensing appears to involve multiple convergent mechanisms.作者: 承認 時間: 2025-4-1 15:11
