作者: evanescent 時(shí)間: 2025-3-21 21:28 作者: Goblet-Cells 時(shí)間: 2025-3-22 01:50 作者: PLIC 時(shí)間: 2025-3-22 07:24
Darstellung der empirischen Untersuchung,ical strategies to derive knowledge from data using labor intensive, inefficient, and costly practices. Complicating the task of data analysis even further, a lot of useful information about drug activities has been historically described in publications and scientific reports in .. This naturally r作者: photopsia 時(shí)間: 2025-3-22 10:33
https://doi.org/10.1007/978-3-8350-5437-0ecognition that the crisis stemmed from an acritical (and sometimes dull) application of statistical methods to the experimental results is the basis for re- examine the quantitative approaches to biology. Here we give a proof-of-concept of how the prophetic statements made by Weaver (one of the fat作者: 拍翅 時(shí)間: 2025-3-22 15:36 作者: 流逝 時(shí)間: 2025-3-22 20:33 作者: Highbrow 時(shí)間: 2025-3-23 00:54
Darstellung der empirischen Untersuchung, of the type of cancer. PO therapy is designed to inhibit the effects of putative oncogenic mutations that supposedly drive tumorigenesis, but this approach has only improved the clinical outcomes of a picked minority of patients, as PO-based treatments almost universally fail to eradicate the tumor作者: 魯莽 時(shí)間: 2025-3-23 05:14 作者: 最低點(diǎn) 時(shí)間: 2025-3-23 05:45
https://doi.org/10.1007/978-3-642-95832-8o abrogate cancer progression. Herein, we aimed to systematize the information regarding steps of EMT that can be druggable and potential therapeutics that can be used to suppress epithelial-mesenchymal plasticity. EMT can be targeted through its suppression or reversal in cancer cells directly. Des作者: 讓你明白 時(shí)間: 2025-3-23 12:56
https://doi.org/10.1007/978-3-7091-6891-2any cancers, including breast cancer, gastric cancer, esophageal cancer, lung cancer, cervical and ovarian cancers, melanoma and others. As macrophages are involved in many steps of cancer development such as primary tumor growth, angiogenesis and lymphangiogenesis, invasion and metastasis, suppress作者: Hallmark 時(shí)間: 2025-3-23 14:46 作者: minimal 時(shí)間: 2025-3-23 21:34 作者: 閑蕩 時(shí)間: 2025-3-24 02:16
https://doi.org/10.1007/978-3-8350-9487-1under control of the light:dark cycle. Besides its regulatory pathway involving ganglion cells in the retina, the neural connections between the eyes and the pineal gland include the master circadian clock, the suprachiasmatic nuclei, and the central and peripheral nervous systems. Since pineal mela作者: Autobiography 時(shí)間: 2025-3-24 03:45 作者: Celiac-Plexus 時(shí)間: 2025-3-24 07:31 作者: Esophagus 時(shí)間: 2025-3-24 12:55 作者: 鞠躬 時(shí)間: 2025-3-24 18:51 作者: Spinal-Tap 時(shí)間: 2025-3-24 19:43 作者: NEXUS 時(shí)間: 2025-3-25 02:54 作者: Dealing 時(shí)間: 2025-3-25 07:06 作者: FIS 時(shí)間: 2025-3-25 08:21
Approaching Complex Diseases978-3-030-32857-3Series ISSN 2661-8915 Series E-ISSN 2661-8923 作者: 突襲 時(shí)間: 2025-3-25 13:17 作者: 糾纏,纏繞 時(shí)間: 2025-3-25 19:35
https://doi.org/10.1007/978-3-030-32857-3Efficiency of multi-target drugs; Failing drug discovery; Failure of current medical treatments; Medica作者: cleaver 時(shí)間: 2025-3-25 22:42 作者: Brain-Imaging 時(shí)間: 2025-3-26 02:43 作者: CRACK 時(shí)間: 2025-3-26 08:23
Revisiting the Concept of Human Disease, outbreak of a disease, as they are habitually centered on an integrated representation of the cell biochemical and genetic pathways, and, as such, they discard the contribution of non-genetic factors and microenvironmental constraints. Thereby, since the eighties, the agenda of pharmacology discove作者: 使服水土 時(shí)間: 2025-3-26 12:23
Dynamical Aspects of Pharmacokinetic/Pharmacodynamic & Quantitative Systems Pharmacology Models,al studies in the field of systems biomedicine. In human physiology, complex phenomena?such as heart rate variability are?often associated with the maintenance of homeostasis, whereas loss of complexity is perceived as indication of pathology. In pharmacology, the response of a physiological system 作者: 熱情的我 時(shí)間: 2025-3-26 12:42
The Efficiency of Multi-target Drugs: A Network Approach,ons, less prone to drug resistance phenomena. They thus seem particularly valuable in the fields of complex disorders and infectious diseases. We discuss the generalities of tailored multi-target drug design, including target combination choice, optimization of potency ratio to the different targets作者: 蔓藤圖飾 時(shí)間: 2025-3-26 17:01
Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases,ical strategies to derive knowledge from data using labor intensive, inefficient, and costly practices. Complicating the task of data analysis even further, a lot of useful information about drug activities has been historically described in publications and scientific reports in .. This naturally r作者: 無目標(biāo) 時(shí)間: 2025-3-26 22:53
Big Data, Personalized Medicine and Network Pharmacology: Beyond the Current Paradigms,ecognition that the crisis stemmed from an acritical (and sometimes dull) application of statistical methods to the experimental results is the basis for re- examine the quantitative approaches to biology. Here we give a proof-of-concept of how the prophetic statements made by Weaver (one of the fat作者: collagenase 時(shí)間: 2025-3-27 02:41 作者: Default 時(shí)間: 2025-3-27 07:06
Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread, one of the leading causes of morbidity and mortality across the globe, with around 14?million new cases in 2012, and this figure is set to rise over the next 20?years. The latest statistics from the World Health Organisation show that there were 8.8?million deaths from cancer in 2015. While treatme作者: Inoperable 時(shí)間: 2025-3-27 11:51
Precision Oncology vs Phenotypic Approaches in the Management of Cancer: A Case for the Postmitotic of the type of cancer. PO therapy is designed to inhibit the effects of putative oncogenic mutations that supposedly drive tumorigenesis, but this approach has only improved the clinical outcomes of a picked minority of patients, as PO-based treatments almost universally fail to eradicate the tumor作者: shrill 時(shí)間: 2025-3-27 16:58
,Migrastatics – Anti-metastatic Drugs Targeting Cancer Cell Invasion,tastatic activity of tumor cells rather than their proliferative ability. Therefore, the treatment of solid tumors should be supplemented with drugs that suppress the ability of tumor cells to invade through the surrounding extracellular matrix and form secondary tumors. During invasion, metastatic 作者: 粉筆 時(shí)間: 2025-3-27 20:06
Critical Steps in Epithelial-Mesenchymal Transition as Target for Cancer Treatment,o abrogate cancer progression. Herein, we aimed to systematize the information regarding steps of EMT that can be druggable and potential therapeutics that can be used to suppress epithelial-mesenchymal plasticity. EMT can be targeted through its suppression or reversal in cancer cells directly. Des作者: 刻苦讀書 時(shí)間: 2025-3-28 00:05
,Targeting the Tumor-Associated Macrophages for ‘Normalizing’ Cancer,any cancers, including breast cancer, gastric cancer, esophageal cancer, lung cancer, cervical and ovarian cancers, melanoma and others. As macrophages are involved in many steps of cancer development such as primary tumor growth, angiogenesis and lymphangiogenesis, invasion and metastasis, suppress作者: CANON 時(shí)間: 2025-3-28 03:37 作者: Iniquitous 時(shí)間: 2025-3-28 10:12
Trabectedin, a Drug Acting on Both Cancer Cells and the Tumor Microenvironment, TME establish a complex relationship with cancer cells and may strongly influence disease progression. However, myeloid cells infiltrating tumor tissues promote, rather than stop, cancer progression. Tumor-Associated Macrophages (TAMs) are abundantly present at the TME and here they trigger and per作者: Junction 時(shí)間: 2025-3-28 11:20
Advances in Characterizing Recently-Identified Molecular Actions of Melatonin: Clinical Implicationunder control of the light:dark cycle. Besides its regulatory pathway involving ganglion cells in the retina, the neural connections between the eyes and the pineal gland include the master circadian clock, the suprachiasmatic nuclei, and the central and peripheral nervous systems. Since pineal mela作者: 表臉 時(shí)間: 2025-3-28 17:42
Multitarget Activities of Inositol and Inositol Hexakisphosphate,udies. However, the most striking is their consistent and reproducible anticancer effect, actively investigated and demonstrated in various experimental models during the last decades. Key molecular targets for cancer are PI3K/Akt, MAPK, PKC, AP-1 and NF-κB. Reduced burden of chemotherapy side-effec作者: 預(yù)測 時(shí)間: 2025-3-28 21:20 作者: Analogy 時(shí)間: 2025-3-29 02:37
Synergistic Effects of Chinese Herbal Medicine and Biological Networks,wo or more medicinal herbs for the prevention and treatment of various diseases since antiquity. The key mechanisms of action of CHM for the systematic management of many diseases largely rely on the concept of synergy to reach an optimal clinical outcome with minimal side effects. With the developm作者: 得罪 時(shí)間: 2025-3-29 05:09 作者: Jogging 時(shí)間: 2025-3-29 11:11
Overcoming Antibiotic Resistance: New Perspectives,cal treatments, reduced antimicrobial options, and high mortality rates. Following the Infectious Diseases Society of America (IDSA) initiative to develop 10 new antibacterials within 2020, new molecules are finally available to address the need of active options against multidrug-resistant Gram-neg作者: Urea508 時(shí)間: 2025-3-29 15:24 作者: blackout 時(shí)間: 2025-3-29 17:56
Darstellung der empirischen Untersuchung,and temporal scales (from genes to tissues) in order to fully understand cancer. In this chapter we present an overview of some recent developments in the multiscale mathematical modelling of cancer at each of the three scales and give discuss how this might be used to provide more targeted and pati作者: resuscitation 時(shí)間: 2025-3-29 21:38 作者: 通情達(dá)理 時(shí)間: 2025-3-30 00:57 作者: 先行 時(shí)間: 2025-3-30 06:02
https://doi.org/10.1007/978-3-7091-6891-2heir functional programming. Here, we discuss modern immunotherapeutic approaches of targeting tumor-infiltrating macrophages including inhibition of the recruitment of monocytes to the tumor, activation of apoptosis in macrophages, repolarization, based on the inhibition of pro-tumor activity or st作者: Retrieval 時(shí)間: 2025-3-30 11:09
Josef K?nig,Wolfgang Dorda,Gabriele Erharting a number of prominent aspects of malignancy. Theoretical models have established a useful theoretical framework able to explain insights into the complex interactions taking place between cancer cells and morphogenetic fields, nevertheless a large research effort must be carried out in order to 作者: Brain-Imaging 時(shí)間: 2025-3-30 15:13 作者: padding 時(shí)間: 2025-3-30 16:47
https://doi.org/10.1007/978-3-8350-9487-1vels in non-pineal cells do not exhibit a circadian rhythm and do not depend on circulating melatonin concentrations although when animals are treated with exogenous melatonin it is taken up by presumably all cells. Mitochondria are the presumed site of melatonin synthesis in all cells; the enzymati作者: Orchiectomy 時(shí)間: 2025-3-30 22:24
https://doi.org/10.1007/978-3-8350-9487-1e recently therapeutic antibodies, natural products always hold great importance to fight cancer. . alkaloids, camptothecin derivatives, taxanes, epipodophyllotoxins, etc. are prominent examples for the success of phytochemicals and their derivatives in clinical oncology during the past decades. The作者: 惡名聲 時(shí)間: 2025-3-31 01:38
https://doi.org/10.1007/978-3-8350-9487-1The complex synergistic interactions of CHM components in pharmacokinetics studies and biological networks are also discussed. Despite some of the scientific reports supporting the synergistic effects of multi-herbal and/or herb-drug combinations, the level of evidence remains low particularly in te作者: negotiable 時(shí)間: 2025-3-31 08:46 作者: 事情 時(shí)間: 2025-3-31 11:42
Book 2020 selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biol作者: entice 時(shí)間: 2025-3-31 14:42
Revisiting the Concept of Human Disease,eoretically and methodologically, is no longer tenable. We propose herein a comprehensive model able in capturing the complexity on which the disease relies, thus recognizing a different spatially (multi-level) and timely distributed target array. Moreover, given that a disease is properly a dynamic作者: fulcrum 時(shí)間: 2025-3-31 19:05 作者: 步兵 時(shí)間: 2025-3-31 23:19 作者: AVOW 時(shí)間: 2025-4-1 02:18 作者: 思想 時(shí)間: 2025-4-1 06:13
,Targeting the Tumor-Associated Macrophages for ‘Normalizing’ Cancer,heir functional programming. Here, we discuss modern immunotherapeutic approaches of targeting tumor-infiltrating macrophages including inhibition of the recruitment of monocytes to the tumor, activation of apoptosis in macrophages, repolarization, based on the inhibition of pro-tumor activity or st作者: Inkling 時(shí)間: 2025-4-1 11:49
Tumor Reversion Induced by Embryo and Oocyte Extracts,ing a number of prominent aspects of malignancy. Theoretical models have established a useful theoretical framework able to explain insights into the complex interactions taking place between cancer cells and morphogenetic fields, nevertheless a large research effort must be carried out in order to 作者: 抵制 時(shí)間: 2025-4-1 17:16
Trabectedin, a Drug Acting on Both Cancer Cells and the Tumor Microenvironment, with encouraging results. Nevertheless, targeting only the tumor-promoting macrophages may not be sufficient to definitely eradicate cancer. The finding that the anti-tumor agent trabectedin has wider mechanisms of action than previously perceived, opened novel interesting viewpoints. Trabectedin p
