標題: Titlebook: Applications of Pharmacokinetic Principles in Drug Development; Rajesh Krishna Textbook 2004 Kluwer Academic/Plenum Publishers, New York 2 [打印本頁] 作者: affront 時間: 2025-3-21 18:49
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書目名稱Applications of Pharmacokinetic Principles in Drug Development網(wǎng)絡公開度學科排名
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書目名稱Applications of Pharmacokinetic Principles in Drug Development讀者反饋
書目名稱Applications of Pharmacokinetic Principles in Drug Development讀者反饋學科排名
作者: 自然環(huán)境 時間: 2025-3-21 23:20
Sekund?rprophylaxe in der Gef??chirurgie assure in vivo bioavailability / bioequivalence (BA/BE). Assessing the risk / benefit criteria and global regulatory requirements that may include human studies for formulation or chemistry changes is a key component when determining the ultimate benefit of contemplated product changes.作者: 剛毅 時間: 2025-3-22 04:13 作者: interlude 時間: 2025-3-22 06:46 作者: Pepsin 時間: 2025-3-22 10:37 作者: Servile 時間: 2025-3-22 13:05
Textbook 2004s of topics presented deal with the application of these tools to everyday decisions that a pharmaceutical scientist encounters. The ability to integrate these topics using PK and PO methods has optimized drug development pathways in the clinic. New technologies in the areas of in vitro assays that 作者: BOLUS 時間: 2025-3-22 17:12
K. J. Husfeldt,R. Raschke,M. Mühee to market is only 10-20% (Prentis et al., 1988; Kennedy, 1997). While many factors contribute to a high failure rate, it is somewhat surprising that poor pharmacokinetic properties, such as poor oral bioavailability, account for almost half of the failures in clinical development.作者: arrhythmic 時間: 2025-3-22 23:25
H. Schumacher,N. Diehm,J. R. Allenberges and the width of the therapeutic window between effective and toxic blood concentrations, specific subpopulations might require a dose regimen which diverges from the population average regimen. Unmasking and exploring these special populations during clinical development is one of the focuses of clinical pharmacology.作者: 反省 時間: 2025-3-23 03:56 作者: 增長 時間: 2025-3-23 05:43 作者: 充滿裝飾 時間: 2025-3-23 11:48 作者: 加花粗鄙人 時間: 2025-3-23 17:06
Optimizing Individualized Dosage Regimens of Potentially Toxic Drugs, can evaluate the patient when there are relatively small changes in the total amount of drug in the body between observations, so that if toxicity develops, we detect it in an early stage of its development so we can make the appropriate adjustment in dosage early, rather than later, after toxicity has become more severe and dangerous.作者: 調整 時間: 2025-3-23 21:51
Human Drug Absorption Studies In Early Development,nadequate stability in gastrointestinal (GI) fluids, poor permeability across the intestinal epithelium, enzymatic or non-enzymatic degradation/metabolism in certain GI segments, and complexation with chelating ligands or metal cations normally present in the GI tract.作者: 發(fā)酵劑 時間: 2025-3-23 23:45 作者: debble 時間: 2025-3-24 04:21
Population Pharmacokinetic and Pharmacodynamic Modeling,n group or population of patients or subjects in a manner that will be useful for the treatment of future patients. This is true not only for clinical patient care, but also to optimize each step of drug development, to develop the optimal understanding of drug behavior, so that the next step can be taken most intelligently.作者: 發(fā)現(xiàn) 時間: 2025-3-24 06:37
The series of topics presented deal with the application of these tools to everyday decisions that a pharmaceutical scientist encounters. The ability to integrate these topics using PK and PO methods has optimized drug development pathways in the clinic. New technologies in the areas of in vitro as作者: 生意行為 時間: 2025-3-24 13:32
H. J. Schmid,D. Rühland,U. Augensteinnew afflictions such as AIDS, West Nile Fever, etc. to larger and larger populations. In addition, improved medical treatments of disease have resulted in an increasing incidence of diseases associated with aging such as Alzheimer’s disease, Parkinson’s disease and various forms of cancer.作者: rectocele 時間: 2025-3-24 15:26 作者: Ingredient 時間: 2025-3-24 21:50 作者: anaerobic 時間: 2025-3-24 23:20
The Role of Clinical Pharmacology and of Pharmacokinetics in The Development of Alendronate - A Bony of movement characteristic of these organisms. In addition to its mechanical functions, bone tissue, which constitutes the bulk of the skeletal mass, carries out various physiological functions. Amongst these, hematopoiesis and mineral metabolism stand out.作者: 誘導 時間: 2025-3-25 04:27
H. Schumacher,N. Diehm,J. R. AllenbergPharmacokinetic (PK) and pharmacodynamic (PD) modeling is employed to establish correlation of the concentration-time relationship (PK) with effect-concentration relationship (PD) in order to provide a better understanding of the time course of an effect (PK/PD) after administration of drug.作者: 巫婆 時間: 2025-3-25 10:19
Pharmacokinetic/Pharmacodynamic Modeling in Drug Development,Pharmacokinetic (PK) and pharmacodynamic (PD) modeling is employed to establish correlation of the concentration-time relationship (PK) with effect-concentration relationship (PD) in order to provide a better understanding of the time course of an effect (PK/PD) after administration of drug.作者: 小官 時間: 2025-3-25 13:17 作者: 裝勇敢地做 時間: 2025-3-25 17:25
H. J. Schmid,D. Rühland,U. Augensteinthat is changing every day. Research commitments are complicated by a limited but growing understanding of disease processes as well as the spread of new afflictions such as AIDS, West Nile Fever, etc. to larger and larger populations. In addition, improved medical treatments of disease have resulte作者: flaunt 時間: 2025-3-25 21:06 作者: 土坯 時間: 2025-3-26 00:31
K. J. Husfeldt,R. Raschke,M. Mühetry, biology, pharmacology, clinical sciences, and other disciplines (Drews, 2000). To bring a single drug to market may take years, cost hundreds of millions of dollars, and generally require testing in thousands of human subjects. Most drug candidates never make it as far as human testing and even作者: 財產(chǎn) 時間: 2025-3-26 07:57
K. J. Husfeldt,R. Raschke,M. Mühef drugs, determination of the rates of these enzyme reactions, and the induction or inhibition of drug metabolizing enzymes. The concepts of drug metabolism are incorporated into most aspects of ADME (absorption, distribution, metabolism, and elimination), toxicology, and pharmacology. The importanc作者: 輕率的你 時間: 2025-3-26 10:19
Sekund?rprophylaxe in der Gef??chirurgied during the selection and development phases. Historically, a high proportion of these failures have been due to poor pharmacokinetic properties. To reduce this failure rate, candidate compounds are now being screened for DMPK properties (absorption, distribution, metabolic stability and excretion)作者: 字形刻痕 時間: 2025-3-26 12:56 作者: 貧窮地活 時間: 2025-3-26 17:17
H. Schumacher,N. Diehm,J. R. Allenbergant cases in which the oral co-administration of marketed drug dosage forms with meals resulted in substantial differences in clinical or toxicological response as compared to administration without a meal (Karim, 1985; Karim, Bums et al., 1985; Karim, Burns et al., 1985; Karim, 1986). One of the mo作者: Bouquet 時間: 2025-3-26 21:44 作者: 南極 時間: 2025-3-27 02:20 作者: 凹槽 時間: 2025-3-27 07:18 作者: 換話題 時間: 2025-3-27 10:29
https://doi.org/10.1007/978-3-662-26791-2ormation in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The purpose of population modeling is thus to describe and capture our experience with the behavior of a drug in a certai作者: FAWN 時間: 2025-3-27 17:02 作者: 轎車 時間: 2025-3-27 21:36
Nijhoff International Philosophy Seriesction to important soft tissues, and it serves as mechanical pivot and provides the mechanical advantage to muscles that makes possible the versatility of movement characteristic of these organisms. In addition to its mechanical functions, bone tissue, which constitutes the bulk of the skeletal mass作者: Hemoptysis 時間: 2025-3-27 23:59
Sebastian Schief Dr., Dipl. Soz.ts dosage between one that is too low, and likely to be ineffective on the one hand, or too high, and likely to be toxic, on the other. We must carefully plan and individualize the dosage for each patient, to achieve some desired target goal such as a serum concentration, or its profile over time. W作者: 減至最低 時間: 2025-3-28 03:59 作者: 可行 時間: 2025-3-28 08:43
978-1-4613-4842-9Kluwer Academic/Plenum Publishers, New York 2004作者: 颶風 時間: 2025-3-28 12:18
H. J. Schmid,D. Rühland,U. Augenstein both drugs and putative metabolites in biological matrices such as blood, plasma, serum and urine. Additionally, significantly greater attention is being focused on the metabolic liabilities of these compounds at earlier stages in drug development than ever before. In a continuing effort to keep up作者: 奴才 時間: 2025-3-28 16:56 作者: 天真 時間: 2025-3-28 18:59
H. Schumacher,N. Diehm,J. R. Allenbergtrates a direct pharmacological interaction in which a meal component alters clinical response to oral drug administration dictating marketed product insert warnings and special prescription labeling.作者: overhaul 時間: 2025-3-28 23:56 作者: Accord 時間: 2025-3-29 04:02 作者: CRAFT 時間: 2025-3-29 10:27 作者: Schlemms-Canal 時間: 2025-3-29 11:36 作者: fructose 時間: 2025-3-29 19:28 作者: 機械 時間: 2025-3-29 21:06 作者: maladorit 時間: 2025-3-30 02:35
Bioanalytical Methods: Challenges and Opportunities in Drug Development, both drugs and putative metabolites in biological matrices such as blood, plasma, serum and urine. Additionally, significantly greater attention is being focused on the metabolic liabilities of these compounds at earlier stages in drug development than ever before. In a continuing effort to keep up作者: ARBOR 時間: 2025-3-30 04:37 作者: 產(chǎn)生 時間: 2025-3-30 08:23
Food-Drug Interactions: Drug Development Considerations,trates a direct pharmacological interaction in which a meal component alters clinical response to oral drug administration dictating marketed product insert warnings and special prescription labeling.作者: 不成比例 時間: 2025-3-30 14:43
Drug-Drug Interactions,s in drug exposure and to clinically significant QT prolongation or, in some cases, serious arrhythmias. Mibefradil, also a CYP3A4 substrate, is a potent inhibitor of CYP3A4 and P-gp transporter. Concomitant administration of mibefradil with other CYP3A4 and P-gp substrates can lead to increased adv作者: infringe 時間: 2025-3-30 19:45
Role of Preclinical Metabolism and Pharmacokinetics in The Development of Celecoxib,s that target COX-2 relative to COX-1.brought into clinical use new drugs that obviated the toxicological limitations of older NSAIDs. Celecoxib (Celebrex.), the first drug approved based on this COX-2 selectivity, entered clinical use in 1999. In the context of this chapter, COX-2-selective refers 作者: crescendo 時間: 2025-3-31 00:40
Efficient and Effective Drug Development,that is changing every day. Research commitments are complicated by a limited but growing understanding of disease processes as well as the spread of new afflictions such as AIDS, West Nile Fever, etc. to larger and larger populations. In addition, improved medical treatments of disease have resulte作者: CLOT 時間: 2025-3-31 02:20
Bioanalytical Methods: Challenges and Opportunities in Drug Development,es has been evolving for decades. The uninterrupted introduction of new technologies and the increasing attention being paid by global regulatory authorities to validation issues has continued to shape this scientific field. However, in the last five years, there has been an unprecedented increase b
