作者: FLEET 時(shí)間: 2025-3-22 00:04 作者: 沉默 時(shí)間: 2025-3-22 03:29 作者: 無底 時(shí)間: 2025-3-22 06:16 作者: ARCH 時(shí)間: 2025-3-22 10:49
Elektrische und magnetische Felderlasses called α, β, γ, δ and ρ, have been cloned. Each class consists of several subunit isotypes (for example α.-α.), which may differ only in few amino acids but which differ markedly in their expression patterns in the CNS, both in adulthood and during development.作者: insurgent 時(shí)間: 2025-3-22 16:06
https://doi.org/10.1007/978-3-662-36759-9. 1992). Specifically, tolerance, withdrawal, self-injection, and drug discrimination were evaluated with abecarnil using methods for which data have been previously reported for benzodiazepines and related novel compounds作者: 沉著 時(shí)間: 2025-3-22 18:31
Behavioral Pharmacology of Abecarnil in Baboons: Reduced Dependence and Abuse Potential,. 1992). Specifically, tolerance, withdrawal, self-injection, and drug discrimination were evaluated with abecarnil using methods for which data have been previously reported for benzodiazepines and related novel compounds作者: 有效 時(shí)間: 2025-3-22 22:17
Book 1993molecularpharmacology and into developing new anxiolytic drugs thatinteract selectively with them. Prominent in this researchhas beenthe discovery that ~-carbolines, a differentchemical class frombenzodiazepines, also act at thesereceptors but that their effects are sometimes quitedifferent from tho作者: Mechanics 時(shí)間: 2025-3-23 03:12 作者: Infiltrate 時(shí)間: 2025-3-23 07:43
Abecarnil is a Full Agonist at Some, and a Partial Agonist at Other Recombinant GABAA Receptor Subtlasses called α, β, γ, δ and ρ, have been cloned. Each class consists of several subunit isotypes (for example α.-α.), which may differ only in few amino acids but which differ markedly in their expression patterns in the CNS, both in adulthood and during development.作者: deforestation 時(shí)間: 2025-3-23 13:02
Elektrische und magnetische Felderounds acting on benzodiazepine receptors, but not being [1,4] benzodiazepines, has broadened the pharmacodynamic profile of this class of drugs and has opened a new avenue for designing drugs with advantageous properties.作者: Forehead-Lift 時(shí)間: 2025-3-23 16:47 作者: Compatriot 時(shí)間: 2025-3-23 18:28
Book 1993e development of ~-carbolines from substances inducinganxiety andconvulsions to a novel therapy for anxietystates, achieving a behavioral selectivity through selectiveactions at subtypes of receptors.作者: 尊嚴(yán) 時(shí)間: 2025-3-23 22:42 作者: 朋黨派系 時(shí)間: 2025-3-24 04:29
Abecarnil: A Novel Anxiolytic with Mixed Full Agonist/Partial Agonist Properties in Animal Models oenzodiazepines have been eliminated. In recent years, two approaches have been used to achieve a better dissociation of the effects of benzodiazepine-receptor ligands; the first entails the use of compounds acting at partial agonists at benzodiazepine receptors (Haefely et al. 1990), but with the di作者: AUGER 時(shí)間: 2025-3-24 06:55
Abecarnil Shows Reduced Tolerance Development and Dependence Potential in Comparison to Diazepam: Ahermore, again unlike full agonists, physical dependence could not be induced in squirrel monkeys after repeated very high doses of bretazenil as assessed by challenge with the BZ-receptor antagonist, flumazenil (Haefely et al. 1990). Although these data on bretazenil indicate that partial BZ-recept作者: Pageant 時(shí)間: 2025-3-24 13:28
Abecarnil Used to Treat Benzodiazepine Withdrawal,and the reinstatement of the drug of dependence terminates the symptoms. Thus, we have argued that the occurrence of anxiety, a key symptom of benzodiazepine withdrawal, may be critical in the maintenance of chronic benzodiazepine taking (Emmett-Oglesby et al. 1990).作者: STALL 時(shí)間: 2025-3-24 18:06
0931-6795 e wayforthe development of ~-carbolines from substances inducinganxiety andconvulsions to a novel therapy for anxietystates, achieving a behavioral selectivity through selectiveactions at subtypes of receptors.978-3-642-78453-8978-3-642-78451-4Series ISSN 0931-6795 作者: MAIZE 時(shí)間: 2025-3-24 20:30 作者: 中世紀(jì) 時(shí)間: 2025-3-24 23:43
,Zeitlich ver?nderliche magnetische Felder,enzodiazepines have been eliminated. In recent years, two approaches have been used to achieve a better dissociation of the effects of benzodiazepine-receptor ligands; the first entails the use of compounds acting at partial agonists at benzodiazepine receptors (Haefely et al. 1990), but with the di作者: 打谷工具 時(shí)間: 2025-3-25 07:22
Messung der Induktionskoeffizienten,hermore, again unlike full agonists, physical dependence could not be induced in squirrel monkeys after repeated very high doses of bretazenil as assessed by challenge with the BZ-receptor antagonist, flumazenil (Haefely et al. 1990). Although these data on bretazenil indicate that partial BZ-recept作者: follicular-unit 時(shí)間: 2025-3-25 08:21
https://doi.org/10.1007/978-3-642-48064-5and the reinstatement of the drug of dependence terminates the symptoms. Thus, we have argued that the occurrence of anxiety, a key symptom of benzodiazepine withdrawal, may be critical in the maintenance of chronic benzodiazepine taking (Emmett-Oglesby et al. 1990).作者: fiscal 時(shí)間: 2025-3-25 13:10 作者: ureter 時(shí)間: 2025-3-25 19:17 作者: Hot-Flash 時(shí)間: 2025-3-25 21:50
Molecular Biology of Gamma-Aminobutyric Acid Type A/Benzodiazepine Receptors, years, mainly as a result of modern molecular-biology techniques, the understanding of the pharmacology, biochemistry, and electrophysiology of these channels has advanced greatly. The family of ligand-gated ion channels now comprises the molecularly related nicotinic acetylcholine receptors (AChR)作者: Osteoarthritis 時(shí)間: 2025-3-26 00:35 作者: 自戀 時(shí)間: 2025-3-26 08:14
Abecarnil is a Full Agonist at Some, and a Partial Agonist at Other Recombinant GABAA Receptor Subtine-gated ion channels reduces neuronal excitability. These anion channels belong to a ligand-gated ion channel family and are formed by pentamers of five membrane-spanning subunits. For the vertebrate GABA. receptor, 16 such receptor subunits, divided by sequence and functional homology into five c作者: Fortuitous 時(shí)間: 2025-3-26 09:43 作者: 真 時(shí)間: 2025-3-26 13:28
Abecarnil: A Novel Anxiolytic with Mixed Full Agonist/Partial Agonist Properties in Animal Models omber of properties which limit their use or which give rise to problems on withdrawal. Thus, currently available benzodiazepine anxiolytics are sedative and muscle relaxant, induce memory impairment, increase the intoxicating potency of alcohol, may be subject to nontherapeutic use (abuse), and, fol作者: EXULT 時(shí)間: 2025-3-26 20:20
Abecarnil Shows Reduced Tolerance Development and Dependence Potential in Comparison to Diazepam: Arer 1983; Woods et al. 1987; Haefely et al. 1990). Recent reports have indicated that partial (low efficacy) BZ-receptor agonists, i. e., compounds which induce smaller fractional responses in their target cells than do full agonists at the same fractional receptor occupancy, may have advantages in 作者: linear 時(shí)間: 2025-3-26 23:17 作者: MIRTH 時(shí)間: 2025-3-27 03:01 作者: 閃光你我 時(shí)間: 2025-3-27 05:38
,Abecarnil: A New ?-Carboline Anxiolytic Preliminary Clinical Pharmacology,mmisse and Hayes 1987). However, their depressant effects on the central nervous system (CNS), expressed as sedation, ataxia and often amnesia, as well as their dependence potential after long-term use, often complicate the course of the treatment.作者: 松雞 時(shí)間: 2025-3-27 11:58 作者: exclusice 時(shí)間: 2025-3-27 16:36
,Station?re elektrische Felder,epine receptor (BZ receptor). Although this compound was not the endogenous ligand but an artifact of the isolation procedure, it was considered a promising lead for the development of psychotropic drugs acting via the BZ receptor because of the following features:作者: hieroglyphic 時(shí)間: 2025-3-27 20:34 作者: 撫育 時(shí)間: 2025-3-28 01:53
Elektrische und magnetische Felder mid-1980s all members of this pharmacological class were of a very similar nature chemically all being [1,4] benzodiazepine molecules (except clordiazepoxide, Fig. 1). Surprisingly, all new compounds discovered for almost three decades with the characteristic diazepam-like anxiolytic, hypnotic, and作者: cogitate 時(shí)間: 2025-3-28 04:07 作者: 地名表 時(shí)間: 2025-3-28 06:17 作者: 陰謀 時(shí)間: 2025-3-28 10:33
Elektrische und magnetische Feldere thought to assemble to form individual chloride-channel complexes bearing GABA. receptors and their associated modulatory sites. Five distinct subunit classes, some containing several isoforms (α., β., γ., 5 and ρ.) encoded by separate genes, have been identified by molecular cloning (see e.g., Ol作者: 打包 時(shí)間: 2025-3-28 15:26 作者: Jubilation 時(shí)間: 2025-3-28 19:11
Elektrische und magnetische Feldercological efficacy and clinical profile of the agonist ligands for benzodiazepine recognition sites (see review Biggio and Costa 1990; Biggio et al. 1992). Accordingly, anxiolytic and anticonvulsant drugs which enhance the function of GABAergic transmission with a low intrinsic activity are classifi作者: THE 時(shí)間: 2025-3-28 23:32
,Zeitlich ver?nderliche magnetische Felder,mber of properties which limit their use or which give rise to problems on withdrawal. Thus, currently available benzodiazepine anxiolytics are sedative and muscle relaxant, induce memory impairment, increase the intoxicating potency of alcohol, may be subject to nontherapeutic use (abuse), and, fol作者: 抵押貸款 時(shí)間: 2025-3-29 06:12
Messung der Induktionskoeffizienten,rer 1983; Woods et al. 1987; Haefely et al. 1990). Recent reports have indicated that partial (low efficacy) BZ-receptor agonists, i. e., compounds which induce smaller fractional responses in their target cells than do full agonists at the same fractional receptor occupancy, may have advantages in 作者: 的染料 時(shí)間: 2025-3-29 07:31
https://doi.org/10.1007/978-3-662-36759-9e benzodiazepine binding site on the gamma-aminobutyric acid type A (GABA.)-receptor complex. Its distinct profile of biochemical and behavioral effects has been suggested to indicate partial and/or selective benzodiazepine-receptor activity (Stephens et al. 1990). A series of experiments in baboons作者: essential-fats 時(shí)間: 2025-3-29 11:52 作者: Conquest 時(shí)間: 2025-3-29 18:09 作者: 祖?zhèn)?nbsp; 時(shí)間: 2025-3-29 23:09
