作者: 大暴雨 時(shí)間: 2025-3-21 22:21 作者: Foment 時(shí)間: 2025-3-22 02:57
Electronic Commerce und Kundenbindungemphasis on fermentation products. The detailed reports by . in 1957 [1] and . et al in 1966 [3] discussed at considerable length the many factors that influenced the early development of the program. Although it is not possible to discuss those factors in detail here, I will attempt to present some作者: SPER 時(shí)間: 2025-3-22 06:01
Friedhelm Bliemel,Georg Fassottrganisms, their fermentation, screening productivity, antineoplastic structures of interest, and future plans follows..NCI initiated its fermentation program in 1956 and, during the next four years, the primary organisms isolated and screened for their abilities to produce antineoplastic agents were作者: 孵卵器 時(shí)間: 2025-3-22 08:58 作者: Intercept 時(shí)間: 2025-3-22 13:53
Electronic Commerce und Kundenbindung this paper, “Microbial transformations” will refer to reactions catalyzed by microbial enzymes, especially when desired and useful metabolites accumulate in fermentation media. Microbial transformations have tremendous potential for use in the development of new antitumor drugs. Concepts related to作者: 擁護(hù)者 時(shí)間: 2025-3-22 17:21
Rechtliche Aspekte des Electronic Commerceethods have involved a microbial or antimetabolite prescreen [7], or tissue culture cytotoxicity assay systems [6], prior to testing of the culture filtrate in animals. In the program that will be discussed here, all fermented beers are screened initially against the L1210 and KB9 cell lines for cyt作者: 過(guò)份好問(wèn) 時(shí)間: 2025-3-22 22:31 作者: Astigmatism 時(shí)間: 2025-3-23 02:27 作者: Predigest 時(shí)間: 2025-3-23 05:45
Friedhelm Bliemel,Georg Fassottiotics in 1953. During the last 15 years, there has been great progress in studies of the mechanisms of cytotoxic actions of antitumor compounds. These studies have shown that antitumor compounds bind or react with DNA, inhibit DNA or RNA synthesis, inhibit protein synthesis, interfere with membrane作者: Hyaluronic-Acid 時(shí)間: 2025-3-23 11:16
Friedhelm Bliemel,Andreas Eggert,Kai Adolphsnd, an adjuvant chemotherapy to surgery; and third, an adjuvant chemotherapy to radiotherapy. Adjuvant chemotherapy to radiotherapy has only been started very recently; radiotherapy is performed under laparotomy followed by chemotherapy. Sometimes, chemotherapy is performed before laparotomy and irr作者: 無(wú)禮回復(fù) 時(shí)間: 2025-3-23 17:21
Torsten Tomczak,Marcus Sch?gel,Ben Birkhofernstration of antitumor activity against a broad spectrum of transplanted animal tumours [2]. Mitomycin C was reported to have a high degree of efficacy for human cancer, which prompted a cooperative multiinstitution evaluation of this agent in the United States. A preliminary summary of the results 作者: 一窩小鳥(niǎo) 時(shí)間: 2025-3-23 21:21 作者: Lumbar-Stenosis 時(shí)間: 2025-3-23 23:50 作者: Mucosa 時(shí)間: 2025-3-24 04:10 作者: 下邊深陷 時(shí)間: 2025-3-24 10:18
https://doi.org/10.1007/978-3-322-93133-7posed the following principle: Even a cytotoxic agent may exhibit therapeutic action against certain types of tumors if it is distributed in the tumor in a higher concentration than in other tissues, or if it is not inactivated or activated in those tumors. This principle has been exemplified by the作者: 賭博 時(shí)間: 2025-3-24 11:44 作者: Laconic 時(shí)間: 2025-3-24 18:53 作者: visual-cortex 時(shí)間: 2025-3-24 19:45 作者: 勛章 時(shí)間: 2025-3-25 01:03 作者: AWE 時(shí)間: 2025-3-25 06:10
Electronic Commerce und Kundenbindungemphasis on fermentation products. The detailed reports by . in 1957 [1] and . et al in 1966 [3] discussed at considerable length the many factors that influenced the early development of the program. Although it is not possible to discuss those factors in detail here, I will attempt to present some of the highlights.作者: Factual 時(shí)間: 2025-3-25 09:55
Rahmenbedingungen der Online-Kommunikationantibacterial activity against Gram-positive organisms and to have antitumor activity against L1210 leukemia. It was also found by Kunimoto et. al. [2] that its effects on DNA synthesis and cell division of HeLa cells are reversed by incubation with trypsin. This suggests an action of the drug at the surface of the cell membrane.作者: Lucubrate 時(shí)間: 2025-3-25 15:17
Friedhelm Bliemel,Georg Fassottpy in the treatment of esophagal, bronchogenic and intra-oral carcinomas. The objective of this study was to determine whether the combined use of bleomycin with radiotherapy would yield results superior to those of radiotherapy alone. This report presents the preliminary data accumulated in this study up to the present time.作者: Chameleon 時(shí)間: 2025-3-25 16:36 作者: instill 時(shí)間: 2025-3-25 23:40
Summary of Clinical Data on Antitumor Antibiotics in Japan,nophylin, and some, such as aclacinomycin A, have just entered the phase I study. The most widely used drugs are mitomycin C and bleomycin. Neocarzinostatin and adriamycin are used in rather limited cases at present.作者: STYX 時(shí)間: 2025-3-26 00:37 作者: 爆米花 時(shí)間: 2025-3-26 05:35 作者: 有特色 時(shí)間: 2025-3-26 10:42
Combined Use of Bleomycin with Radiation in the Treatment of Cancer,py in the treatment of esophagal, bronchogenic and intra-oral carcinomas. The objective of this study was to determine whether the combined use of bleomycin with radiotherapy would yield results superior to those of radiotherapy alone. This report presents the preliminary data accumulated in this study up to the present time.作者: Nomadic 時(shí)間: 2025-3-26 14:56 作者: Constant 時(shí)間: 2025-3-26 18:12 作者: 預(yù)定 時(shí)間: 2025-3-26 23:17 作者: 放肆的你 時(shí)間: 2025-3-27 03:31
Experimental Results with the Combination of Bleomycin Plus Mitomycin C,Bleomycin, a water-soluble basic glycopeptide antibiotic, is well known for treatment against human squamous cell carcinoma and malignant lymphoma [4, 5, 14, 17]. Recently, Miyamoto et al. reported that a sequential combination of bleomycin and mitomycin C induced a drastic remission effect on advanced cervical cancer [7].作者: ADORE 時(shí)間: 2025-3-27 07:40
Role of Antitumor Antibiotics in Current Oncologic Practice,course of this discussion, we will present specific points to aid the future development in this important area. Table 1 lists the agents to be described and the areas in which they have exhibited a major impact in clinical practice.作者: strain 時(shí)間: 2025-3-27 11:28
In Vivo Antitumor Evaluation of Antibiotics. Selected Results from the Drug Evaluation Program of t(DCT), National Cancer Institute (NCI) examined over 1000 fermentation broths for activity against one or more animal tumors. The yield of “active” materials from this in vivo screening program are presented elsewhere in this volume [2].作者: Duodenitis 時(shí)間: 2025-3-27 16:40 作者: Hiatal-Hernia 時(shí)間: 2025-3-27 18:48
Rechtliche Aspekte des Electronic Commerceof this screening technique to eliminate knowns as quickly as possible in the early stages of the program has been very successful; it has increased the efficiency of our overall program. The purpose of this paper is to present some of the details of our “fingerprint” techniques.作者: Anterior 時(shí)間: 2025-3-28 00:47
Torsten Tomczak,Marcus Sch?gel,Ben Birkhoferologic toxicity. It was concluded that mitomycin C had an extremely narrow therapeutic index, while demonstrating only limited efficacy. The result was a sharply reduced interest for mitomycin C as an anticancer agent in the United States.作者: Arresting 時(shí)間: 2025-3-28 02:52 作者: 有權(quán) 時(shí)間: 2025-3-28 06:27
Fingerprint Methods used to Identify known Antineoplastic Agents in Culture Filtrates,of this screening technique to eliminate knowns as quickly as possible in the early stages of the program has been very successful; it has increased the efficiency of our overall program. The purpose of this paper is to present some of the details of our “fingerprint” techniques.作者: 錯(cuò) 時(shí)間: 2025-3-28 11:42 作者: BILIO 時(shí)間: 2025-3-28 18:31
A Review of the Bleomycin Experience in the United States,t became clear that BLM had not only unique antitumor potential but also unique toxic properties. Unlike most other antineoplastics, BLM demonstrated little myelotoxicity. Its acute toxicities proved to be dermatitis and allergy, and its major dose-limiting chronic toxicity, pulmonary fibrosis.作者: Missile 時(shí)間: 2025-3-28 22:24 作者: 煩人 時(shí)間: 2025-3-28 23:36 作者: transient-pain 時(shí)間: 2025-3-29 06:38 作者: 撤退 時(shí)間: 2025-3-29 07:24 作者: aesthetician 時(shí)間: 2025-3-29 14:25
Electronic commerce: An overview,course of this discussion, we will present specific points to aid the future development in this important area. Table 1 lists the agents to be described and the areas in which they have exhibited a major impact in clinical practice.作者: 安心地散步 時(shí)間: 2025-3-29 17:45 作者: irreducible 時(shí)間: 2025-3-29 19:47 作者: 鋼筆記下懲罰 時(shí)間: 2025-3-30 03:01
Summary of Clinical Data on Antitumor Antibiotics in Japan,nophylin, and some, such as aclacinomycin A, have just entered the phase I study. The most widely used drugs are mitomycin C and bleomycin. Neocarzinostatin and adriamycin are used in rather limited cases at present.作者: 睨視 時(shí)間: 2025-3-30 06:02 作者: SENT 時(shí)間: 2025-3-30 08:29 作者: 原告 時(shí)間: 2025-3-30 15:50
,National Cancer Institute’s Fermentation Development Program,rganisms, their fermentation, screening productivity, antineoplastic structures of interest, and future plans follows..NCI initiated its fermentation program in 1956 and, during the next four years, the primary organisms isolated and screened for their abilities to produce antineoplastic agents were作者: 保存 時(shí)間: 2025-3-30 17:19 作者: 輕快走過(guò) 時(shí)間: 2025-3-30 23:00 作者: LEVY 時(shí)間: 2025-3-31 01:32 作者: 誘使 時(shí)間: 2025-3-31 07:06
Criteria for Selection of New Analogs of Antitumor Antibiotics,for clinical trial. There are a considerable number of analogs of alkylating agents, purine and pyrimidine antagonists, folic acid antagonists, dimethane sulfonates, benzimidazols, antibiotics of a number of subcategories, and other classes of drugs which have demonstrable activity in antitumor test作者: 1FAWN 時(shí)間: 2025-3-31 12:01 作者: 外觀 時(shí)間: 2025-3-31 13:34 作者: FIS 時(shí)間: 2025-3-31 20:57
The Current Status of Chemotherapy for Gastric Cancer in Japan with Special Emphasis on Mitomycin Cnd, an adjuvant chemotherapy to surgery; and third, an adjuvant chemotherapy to radiotherapy. Adjuvant chemotherapy to radiotherapy has only been started very recently; radiotherapy is performed under laparotomy followed by chemotherapy. Sometimes, chemotherapy is performed before laparotomy and irr作者: obtuse 時(shí)間: 2025-3-31 23:31
Mitomycin C: Experience in the United States, with Emphasis on Gastric Cancer,nstration of antitumor activity against a broad spectrum of transplanted animal tumours [2]. Mitomycin C was reported to have a high degree of efficacy for human cancer, which prompted a cooperative multiinstitution evaluation of this agent in the United States. A preliminary summary of the results 作者: Notify 時(shí)間: 2025-4-1 04:53
A Review of the Bleomycin Experience in the United States,o the United States, active world wide efforts have been made to evaluate this drug clinically. In the United States, these efforts were initially unfocused, with many institutions of oncology and cooperative groups pursuing broad Phase II trials looking for promising single agent activity. After th
