作者: 聯(lián)想 時間: 2025-3-21 22:26
Electron Spectroscopy for Surface Analysisviding important insights into their roles in tumorigenesis or normal growth and development (.–.). Although attention has been focused recently on the development of antisense ODN as therapeutics for a variety of diseases, including cancer (.), systemic application of ODN to treat tumors other than作者: falsehood 時間: 2025-3-22 03:54 作者: NEX 時間: 2025-3-22 07:27 作者: sebaceous-gland 時間: 2025-3-22 11:47
https://doi.org/10.1007/978-1-4613-2901-5human diseases, a major problem is that most extracellular compartments are constantly mixing with the blood, lymph, cerebrospinal fluid (CSF), and so forth, and thus constantly diluting the oligonucleotide. A possibly unique exception to this problem is the vitreous, a gelatinous fluid overlying th作者: Anticonvulsants 時間: 2025-3-22 15:36 作者: Noisome 時間: 2025-3-22 18:30
Band-Structure Calculation Methods,signs and symptoms of viral infections are frequently caused by the expression or overexpression of the acquired genes. Based on this basic concept, such acquired genetic diseases should be amenable to treatment by a specific block of gene expression. Gene expression can be blocked at different leve作者: 免費(fèi) 時間: 2025-3-22 23:27 作者: 摻和 時間: 2025-3-23 02:47 作者: Synthesize 時間: 2025-3-23 05:48 作者: harpsichord 時間: 2025-3-23 11:02 作者: inquisitive 時間: 2025-3-23 15:41 作者: 金盤是高原 時間: 2025-3-23 21:05
Electron Spin Relaxation in Liquid Crystals,enetic disorders because of their ablhty to inhibit expression of a disease-associated gene in a sequence-specific manner. Gene expression is inhibited by hybrid ization of the oligonucleotide to sequences in the gene or the messenger RNA (mRNA) target by Watson-Crick base pairing. The first example作者: SSRIS 時間: 2025-3-24 00:21 作者: Schlemms-Canal 時間: 2025-3-24 03:41 作者: grieve 時間: 2025-3-24 07:52
Electron Spin Relaxation Phenomena in Solidsherapeutic agent. in principle, an antisense oligonucleotide targeted at a gene essential for neoplastic cell growth should interfere with only that gene’s expression, resulting in arrest of cancer cell growth.作者: MURAL 時間: 2025-3-24 12:28
H. I. Starnberg,H.E. Brauer,H. P. HughesBiological science is a rapidly flowing experimental stream, at times encountering a dam that impedes further progress. At such a pomt, a single crack may induce a major breakthrough Discovery of the double helical structure of DNA in 1953 (.) caused such an event, with flooding of new information into the area now known as molecular biology.作者: POINT 時間: 2025-3-24 18:25
History of Antisense Oligonucleotides,Biological science is a rapidly flowing experimental stream, at times encountering a dam that impedes further progress. At such a pomt, a single crack may induce a major breakthrough Discovery of the double helical structure of DNA in 1953 (.) caused such an event, with flooding of new information into the area now known as molecular biology.作者: 無禮回復(fù) 時間: 2025-3-24 20:54 作者: 粗魯性質(zhì) 時間: 2025-3-25 02:18 作者: Juvenile 時間: 2025-3-25 06:05
Protein Kinase-A Directed Antisense Therapy of Tumor Growth In Vivo,herapeutic agent. in principle, an antisense oligonucleotide targeted at a gene essential for neoplastic cell growth should interfere with only that gene’s expression, resulting in arrest of cancer cell growth.作者: aspect 時間: 2025-3-25 09:41 作者: Monocle 時間: 2025-3-25 13:13
Electron-Excited Core Level Spectroscopies,rential cloning procedures will identify rare genes expressed in specific physiological or pathological situations (., .). In both cases, establishing the precise function of the identified gene is an essential step for the understanding of the cellular mechanisms that either lead to the disease or are pivotal in important physiological processes.作者: 小教堂 時間: 2025-3-25 15:58
https://doi.org/10.1007/978-3-642-60403-4mic DNA (.).In humans, . gene locus has been mapped to chromosome 6 (6q22-23) However, . mRNA expressed in thymus contains transcripts originating from chromosome 17 (17q25), suggesting that an mtermolecular recombinant event may be involved in the formation of the mature protein (.).作者: 現(xiàn)代 時間: 2025-3-25 21:17 作者: Infelicity 時間: 2025-3-26 01:38
Electron Spin Relaxation Phenomena in Solids, patients refractory to Ara-C die within months. Hence, new therapeutic agents must be identified capable of enhanced remission rates, diminished treatment-related mortality, or that can achieve remissions in refractory patients.作者: 包裹 時間: 2025-3-26 04:43 作者: 竊喜 時間: 2025-3-26 10:54
c-, in Smooth Muscle Cells,mic DNA (.).In humans, . gene locus has been mapped to chromosome 6 (6q22-23) However, . mRNA expressed in thymus contains transcripts originating from chromosome 17 (17q25), suggesting that an mtermolecular recombinant event may be involved in the formation of the mature protein (.).作者: 翻動 時間: 2025-3-26 15:47
Antisense Therapy of Hepatitis B Virus Infection,uch acquired genetic diseases should be amenable to treatment by a specific block of gene expression. Gene expression can be blocked at different levels by the following strategtes: sense strategy, antigene strategy, ribozymes, antisense strategy, and interfering peptrdes or proteins (.).作者: exhilaration 時間: 2025-3-26 17:42
Continuous Infusion of Antisense Phosphorothioate Therapeutics,, patients refractory to Ara-C die within months. Hence, new therapeutic agents must be identified capable of enhanced remission rates, diminished treatment-related mortality, or that can achieve remissions in refractory patients.作者: 緩解 時間: 2025-3-26 20:57
Book 19961st editionic and their application in various in vivo model systems. The book‘s high-profile contributors provide timely accounts of their state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods 作者: pancreas 時間: 2025-3-27 01:59 作者: OCTO 時間: 2025-3-27 08:07 作者: Enliven 時間: 2025-3-27 09:46 作者: sed-rate 時間: 2025-3-27 14:40 作者: 協(xié)定 時間: 2025-3-27 19:31
Electron Spin Relaxation in Liquid Crystals,ide inhibited Rous sarcoma virus replication in cell culture. Since then, the field has progressed enormously. Numerous studies have demonstrated the ability of antisense oligonucleotides to modulate gene expression (.–.). Accompanying chapters in this volume describe the use of antisense oligonucleotides for vanous disease targets.作者: arboretum 時間: 2025-3-28 01:32 作者: 擁擠前 時間: 2025-3-28 03:55
Comparative Pharmacokinetics of Antisense Oligonucleotides,ide inhibited Rous sarcoma virus replication in cell culture. Since then, the field has progressed enormously. Numerous studies have demonstrated the ability of antisense oligonucleotides to modulate gene expression (.–.). Accompanying chapters in this volume describe the use of antisense oligonucleotides for vanous disease targets.作者: 利用 時間: 2025-3-28 09:01 作者: 本能 時間: 2025-3-28 12:26 作者: synovium 時間: 2025-3-28 15:06 作者: rectum 時間: 2025-3-28 20:00 作者: compassion 時間: 2025-3-29 01:43
Antisense Efficacy,viding important insights into their roles in tumorigenesis or normal growth and development (.–.). Although attention has been focused recently on the development of antisense ODN as therapeutics for a variety of diseases, including cancer (.), systemic application of ODN to treat tumors other than作者: commonsense 時間: 2025-3-29 04:35 作者: 竊喜 時間: 2025-3-29 08:04
Antisense Tumor Therapy,toncogenes (.). The imphcation is that the targets that must be attacked in neoplastic cells are normal cellular genes that have sustained some activating lesion. The . family of mammalian proto-oncogenes includes three members, termed Ha-., Ki-., and N-., that are found to be activated very often i作者: 抗體 時間: 2025-3-29 12:48
Antisense Inhibition of Protein Synthesis and Function,human diseases, a major problem is that most extracellular compartments are constantly mixing with the blood, lymph, cerebrospinal fluid (CSF), and so forth, and thus constantly diluting the oligonucleotide. A possibly unique exception to this problem is the vitreous, a gelatinous fluid overlying th作者: 反饋 時間: 2025-3-29 17:20
c-, in Smooth Muscle Cells, vn-us (AMV) and E26 leukemia virus (.). The . gene is highly conserved in eukaryotes, and it usually consists of 15 exons spanning over 35 kb of genomic DNA (.).In humans, . gene locus has been mapped to chromosome 6 (6q22-23) However, . mRNA expressed in thymus contains transcripts originating fro作者: 帶來 時間: 2025-3-29 23:45 作者: photophobia 時間: 2025-3-30 02:21
Antisense-Mediated Inhibition of Protein Synthesis,ics. The specrficlty of the hybridization reaction and the surprisingly efficient uptake of synthetrc oligonucleotide derivatives provide a new class of selective protein synthesis inhibitors. Concurrently with the development of the antisense technology, elucidation of the pathogenetic role of mdrv作者: commensurate 時間: 2025-3-30 05:00 作者: accessory 時間: 2025-3-30 11:07
Continuous Infusion of Antisense Phosphorothioate Therapeutics,rone. Unfortunately, most patients relapse from initial remission. Nearly one-fifth of early relapses experience treatment-related deaths. In addition, patients refractory to Ara-C die within months. Hence, new therapeutic agents must be identified capable of enhanced remission rates, diminished tre作者: 別炫耀 時間: 2025-3-30 12:31
Protein Kinase-A Directed Antisense Therapy of Tumor Growth In Vivo,herapeutic agent. in principle, an antisense oligonucleotide targeted at a gene essential for neoplastic cell growth should interfere with only that gene’s expression, resulting in arrest of cancer cell growth.作者: 放逐 時間: 2025-3-30 19:38 作者: aviator 時間: 2025-3-31 00:00
Comparative Pharmacokinetics of Antisense Oligonucleotides,enetic disorders because of their ablhty to inhibit expression of a disease-associated gene in a sequence-specific manner. Gene expression is inhibited by hybrid ization of the oligonucleotide to sequences in the gene or the messenger RNA (mRNA) target by Watson-Crick base pairing. The first example作者: 潛移默化 時間: 2025-3-31 00:51 作者: accomplishment 時間: 2025-3-31 08:34
https://doi.org/10.1007/978-3-319-33927-6e (.). The principal cause for disassociation of IkB from NFis phosphorylation (.), but it may involve proteolysis of IkB (.) Several autoregulatory loops have been proposed for the involvement of NF-kB in the regulation of the inhibitor IkB. Furthermore, NF-kB has been shown to regulate the transcr作者: deforestation 時間: 2025-3-31 09:43
