標(biāo)題: Titlebook: Antisense Research and Application; Stanley T. Crooke Book 1998 Springer-Verlag Berlin Heidelberg 1998 Anti-Sense.Antisense.Oligonuclotide [打印本頁] 作者: fathom 時間: 2025-3-21 18:46
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作者: hypertension 時間: 2025-3-21 22:58
https://doi.org/10.1007/b115596means to study various neurobiological events, antisense compounds have the potential to be used as therapeutic agents in the management of neuropsychiatric and neurodegenerative disorders. An antisense strategy to reduce the function of neuroreceptors might have a further distinct advantage over tr作者: transient-pain 時間: 2025-3-22 03:31 作者: Exposure 時間: 2025-3-22 07:43 作者: 發(fā)微光 時間: 2025-3-22 11:29
https://doi.org/10.1007/b115596r suppressers, encode proteins that are crucial regulators for both intra-and intercellular signal transduction (.;.;.;.;.;.). This conceptual framework has provided a basis for the development of novel anticancer strategies and therapeutic modalities aimed at inhibiting cancer growth either by bloc作者: dura-mater 時間: 2025-3-22 14:03 作者: 陳腐思想 時間: 2025-3-22 19:17
Antisense Medicinal Chemistry,his, certain limitations as antisense agents have become apparent. While it appears certain that PS drugs will soon become available, in order to continually improve the oligonucleotide drug class and to overcome certain limitations, structural changes to PS are required. To date, a diverse range of作者: 重力 時間: 2025-3-22 21:58 作者: Toxoid-Vaccines 時間: 2025-3-23 02:25 作者: 帶子 時間: 2025-3-23 05:45
Use of Antisense Oligonucleotides to Modify Inflammatory Processes,d that it was possible to attenuate an immune response without causing generalized myelosuppression, thus identifying methods for selectively modulating an immune response. These findings, combined with our vastly increased understanding of how the immune system functions, has opened up tremendous o作者: immunity 時間: 2025-3-23 13:37
Antisense Oligonucleotides and Their Anticancer Activities,r suppressers, encode proteins that are crucial regulators for both intra-and intercellular signal transduction (.;.;.;.;.;.). This conceptual framework has provided a basis for the development of novel anticancer strategies and therapeutic modalities aimed at inhibiting cancer growth either by bloc作者: 補(bǔ)助 時間: 2025-3-23 15:47 作者: 織布機(jī) 時間: 2025-3-23 20:34 作者: chemoprevention 時間: 2025-3-23 22:47
Organic Radicals and Molecular Magnetism,lored for potential therapeutic applications. Thus antisense molecules have presented an opportunity to exploit a single target for multiple therapeutic indications as well as to explore the utility of inhibiting targets which traditional therapeutic agents could not specifically inhibit.作者: demote 時間: 2025-3-24 05:43
Selected Examples of Spectra of Pairs,ypically short therapeutic half-lives limit the usefulness of many antiviral drugs, including nucleoside analogues. More pharmacologically selective and specific antiviral drugs are needed to help limit toxicity to the host while inhibiting viral replication.作者: Freeze 時間: 2025-3-24 09:51
https://doi.org/10.1007/978-3-642-74477-8llular, membrane associated, or at the cell surface. Historically, the screening process for identifying new anticancer agents has selected agents for their ability to inhibit tumor growth in various animal models rather than with significant consideration for target selectivity.作者: helper-T-cells 時間: 2025-3-24 12:26
In Vitro Cellular Uptake, Distribution, and Metabolism of Oligonucleotides, experiments, as well as preliminary clinical data, suggest that antisense therapeutics do work via an antisense mechanism, i.e., by altering intermediary RNA metabolism and ultimately decreasing production of disease-associated gene products ([.]; [.]).作者: Expertise 時間: 2025-3-24 15:29 作者: 公理 時間: 2025-3-24 21:29
Clinical Antiviral Activities,ypically short therapeutic half-lives limit the usefulness of many antiviral drugs, including nucleoside analogues. More pharmacologically selective and specific antiviral drugs are needed to help limit toxicity to the host while inhibiting viral replication.作者: VEIL 時間: 2025-3-25 00:34
,Antisense Oligonucleotides to Protein Kinase C-α and C-, Kinase: Rationale and Clinical Experience llular, membrane associated, or at the cell surface. Historically, the screening process for identifying new anticancer agents has selected agents for their ability to inhibit tumor growth in various animal models rather than with significant consideration for target selectivity.作者: palette 時間: 2025-3-25 07:18 作者: Intervention 時間: 2025-3-25 10:51 作者: 分期付款 時間: 2025-3-25 13:56
Strategies of Electron Probe Data Reduction,t deal is known about their cell and molecular biology. The latter in particular facilitates the choice of a gene target. Accordingly, if ODN were going to be developed as therapeutics, the hematopoietic system seemed an ideal model system.作者: 過多 時間: 2025-3-25 17:36 作者: 徹底檢查 時間: 2025-3-25 20:29 作者: 不可接觸 時間: 2025-3-26 01:26 作者: carotenoids 時間: 2025-3-26 06:09
2.1.5 References for the introduction,hich there are answers. Appropriately, considerable debate continues about the breadth of the utility of the approach and about the type of data required to “prove that a drug works through an antisense mechanism.”作者: COMMA 時間: 2025-3-26 08:53 作者: OFF 時間: 2025-3-26 12:59 作者: 狂怒 時間: 2025-3-26 20:28
Basic Principles of Antisense Therapeutics,hich there are answers. Appropriately, considerable debate continues about the breadth of the utility of the approach and about the type of data required to “prove that a drug works through an antisense mechanism.”作者: 白楊魚 時間: 2025-3-26 23:12 作者: POWER 時間: 2025-3-27 04:03 作者: Muscularis 時間: 2025-3-27 05:43 作者: FLING 時間: 2025-3-27 09:29 作者: Nausea 時間: 2025-3-27 17:17 作者: Capitulate 時間: 2025-3-27 19:01 作者: surmount 時間: 2025-3-28 00:26
0171-2004 the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.978-3-642-63730-8978-3-642-58785-6Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: muscle-fibers 時間: 2025-3-28 04:40 作者: STAT 時間: 2025-3-28 08:33
Electron Paramagnetic Resonance Spectroscopyour (.; .; .) and viral (.; .) indications. The rapid emergence of this class of compounds has placed new demands on the preclinical profiling of therapeutic candidates, particularly with respect to their in vivo behaviour.作者: 同音 時間: 2025-3-28 11:48 作者: 四目在模仿 時間: 2025-3-28 16:05
https://doi.org/10.1007/b115596tly, studies attempting to examine the role of IEGs in the CNS abound. In this chapter we describe studies which have associated IEGs with brain function and demonstrate the emerging role that antisense technology has played in this field and other areas of CNS pharmacology.作者: 鞭打 時間: 2025-3-28 20:44
Standards for Electron Probe Microanalysis,ny cell types upregulate expression of ICAM-1 on their surface. The primary counterligands for ICAM-1 are the β.-integrins lymphocytic function-associated antigen (LFA)-1 and macrophage differentiation antigen (Mac)-1, expressed on leukocytes (.;.).作者: 極小量 時間: 2025-3-28 23:43 作者: CUB 時間: 2025-3-29 03:21 作者: 要控制 時間: 2025-3-29 09:42
2.1.1 List of symbols and abbreviations,y several new biotechnology companies. Various approaches within this area of research attempt to use oligonucleotides as novel drugs, i.e., the use of antisense strands, ribozymes, triplexes and double-stranded nucleic-acid decoys. In the antisense approach, RNA serves as a novel receptor, which wi作者: Immortal 時間: 2025-3-29 15:23
https://doi.org/10.1007/978-3-030-39663-3 a cellular system ([.]). Since that time, enormous progress has been made towards the development of antisense oligo-nucleotides as therapeutic agents against a wide variety of host and viral disease targets ([.]; [.]; [.]). Like other pharmacological agents, these novel compounds have both specifi作者: 帶來墨水 時間: 2025-3-29 19:17 作者: 沉思的魚 時間: 2025-3-29 20:01 作者: 禁止,切斷 時間: 2025-3-30 03:46
Organic Radicals and Molecular Magnetism,get for the antisense molecules, mRNA, is chemically and biologically well defined. This well-defined target is the same for all different possible therapeutic applications, whether the application is antiviral, anticancer, or anti-inflammatory. The specificity with which antisense molecules are cap作者: Substitution 時間: 2025-3-30 05:20 作者: Glucose 時間: 2025-3-30 10:43
https://doi.org/10.1007/b115596d DNA backbones can cause immune activation which is concentration-and length-dependent and sequence-independent. However, the different backbones currently under development for antisense applications differ greatly in the degree to which they induce immune effects. As might be expected, neutral ba作者: 邪惡的你 時間: 2025-3-30 12:54
https://doi.org/10.1007/b115596 (for recent reviews, see Weiss et al. ., .,.; .). The antisense approach has been particularly useful in characterizing the pharmacological properties and biological functions of receptors for neurotransmitters. This is due to the rapid discovery of the molecular structure of new subtypes of neurot作者: 隱語 時間: 2025-3-30 16:59
https://doi.org/10.1007/b115596any cases the stimuli responsible for this change in brain function also activate transcription factors (TF), some of which are of the immediate-early gene (IEG) family. Stimuli of both physiological and pathophysiological significance have been shown to activate the prototypical IEG, c-.. Consequen作者: chandel 時間: 2025-3-30 23:20 作者: 譏笑 時間: 2025-3-31 04:23 作者: Inferior 時間: 2025-3-31 08:04
https://doi.org/10.1007/b115596tant tumors. There is an urgent need for therapeutic alternatives aiming at compounds with better tolerability at efficacious doses that are directed at defined, disease-relevant molecular targets. The progress made in understanding the molecular basis of mammalian cell transformation has led to the作者: Lucubrate 時間: 2025-3-31 09:21 作者: 人造 時間: 2025-3-31 13:54
Selected Examples of Spectra of Pairs, at viral penetration and uncoating or viral genome replication, and the era of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) has helped regenerate interest in antiviral drug discovery and development (Table 1). Discovery of many of the active antivirals 作者: 眼界 時間: 2025-3-31 20:54
https://doi.org/10.1007/978-3-642-74477-8ells relative to that of normal tissue for their therapeutic indices. Small-molecule chemotherapeutic agents have narrow therapeutic indices for a variety of reasons. The most global reason is simply that small molecules do not specifically target cancer cells. However, in addition cytotoxic agents 作者: miscreant 時間: 2025-3-31 22:00 作者: ANTE 時間: 2025-4-1 03:59
Standards for Electron Probe Microanalysis,an intercellular adhesion molecule (ICAM)-1 message. ICAM-1, a member of the immunoglobulin superfamily, is an inducible transmembrane glycoprotein constitutively expressed at low levels on vascular endothelial cells and on a subset of leukocytes (.;.;.). In response to proinflammatory mediators, ma作者: 無法解釋 時間: 2025-4-1 07:59 作者: Harrowing 時間: 2025-4-1 10:23
Stanley T. CrookeA concise, up-to-date report on this important area作者: 預(yù)定 時間: 2025-4-1 18:08 作者: JEER 時間: 2025-4-1 19:04 作者: Additive 時間: 2025-4-1 23:07 作者: 描繪 時間: 2025-4-2 05:18
