標(biāo)題: Titlebook: Antimalarial Drug II; Current Antimalarial Wallace Peters (Professor of Medical Protozoology) Book 1984 Springer-Verlag Berlin Heidelberg 1 [打印本頁(yè)] 作者: 正當(dāng)理由 時(shí)間: 2025-3-21 16:40
書目名稱Antimalarial Drug II影響因子(影響力)
書目名稱Antimalarial Drug II影響因子(影響力)學(xué)科排名
書目名稱Antimalarial Drug II網(wǎng)絡(luò)公開(kāi)度
書目名稱Antimalarial Drug II網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書目名稱Antimalarial Drug II被引頻次
書目名稱Antimalarial Drug II被引頻次學(xué)科排名
書目名稱Antimalarial Drug II年度引用
書目名稱Antimalarial Drug II年度引用學(xué)科排名
書目名稱Antimalarial Drug II讀者反饋
書目名稱Antimalarial Drug II讀者反饋學(xué)科排名
作者: Exclaim 時(shí)間: 2025-3-21 23:43 作者: 一再困擾 時(shí)間: 2025-3-22 03:30
Dihydrofolate Reductase Inhibitorsowerful, selective inhibition of the activity of malarial dihydrofolate reductase (. et al. 1969). Thus, one compound which was inadvertently synthesised as a prodrug and another which derived from a programme of synthesis of untargeted antimetabolites, together stand as prime examples of chemothera作者: 瘙癢 時(shí)間: 2025-3-22 05:04
Lapinone, Menoctone, Hydroxyquinolinequinones and Similar Structures3-(9-hydroxy-9-pentyltetradecyl)1,4-naphthoquinone (II) (lapinone) was synthesised (. et al. 1948a) and shown to be effective in curing patients infected with . (. and . 1951). However, parenteral administration of the drug at fairly high doses was required and this, coupled with the emergence of su作者: Ataxia 時(shí)間: 2025-3-22 09:32
Antibioticsecies, chlortetracycline appeared to be somewhat more active than the other two compounds. The three drugs also exerted a causal prophylactic activity against sporozoite-induced infections of avian malaria. The two tetracyclines and chloramphenicol were the only antibiotics of those tested which wer作者: TERRA 時(shí)間: 2025-3-22 14:09
Book 1984 we asked the contributors to Part 2 of this volume to review very thoroughly the widely scattered but voluminous literature on those few chemical groups that have provided the antimalarial drugs in clinical use at the present time. Much can be learned from the history of their development and the p作者: Invertebrate 時(shí)間: 2025-3-22 20:15 作者: 監(jiān)禁 時(shí)間: 2025-3-22 22:38
Luis Baringo,Miguel Carrión,Ruth Domínguez abandoned (in favour of sontoquine) as being “too toxic for human use.” The magnitude of this error of judgement became apparent when, in the course of the American wartime antimalarial survey (. 1946), CQ proved to be the best of the many compounds which were tested for prophylactic-suppressive ac作者: encomiast 時(shí)間: 2025-3-23 03:18
Maedeh Yazdandoust,Masoud Aliakbar Golkarizontocide is more effective or less toxic than primaquine there is a recognised need for investigations to differentiate the efficacy and the toxicity of prima-quine as well as to discover new, less toxic, tissue schizontocides. Thus the Third Meeting of the Scientific Working Group on the Chemothe作者: Console 時(shí)間: 2025-3-23 07:46 作者: cogent 時(shí)間: 2025-3-23 13:19 作者: 上釉彩 時(shí)間: 2025-3-23 15:23 作者: Middle-Ear 時(shí)間: 2025-3-23 19:16 作者: 軍火 時(shí)間: 2025-3-23 23:22 作者: 都相信我的話 時(shí)間: 2025-3-24 03:25 作者: 潛移默化 時(shí)間: 2025-3-24 06:58
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/a/image/158588.jpg作者: 謊言 時(shí)間: 2025-3-24 13:01
Antimalarial Drug II978-3-642-69254-3Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 調(diào)色板 時(shí)間: 2025-3-24 17:07
Luis Baringo,Miguel Carrión,Ruth Domínguezganic chemistry (. and . 1966; . 1967). It was first prepared in 1934 by H. Andersag in the Elberfeld-Leverkusen laboratories of the I. G. Farbenindustrie, as part of a programme which included the synthesis of such important compounds as mepacrine, pentaquine, isopentaquine, pamaquine, primaquine, 作者: 索賠 時(shí)間: 2025-3-24 21:53
Luis Baringo,Miguel Carrión,Ruth Domínguezpeat once more all the known facts about quinine, but rather to select and critically discuss those properties which are essential for an assessment of its merits and its defaults in comparison with its modern successors. Since only those properties will be mentioned which contribute to an appraisal作者: Crater 時(shí)間: 2025-3-25 01:30 作者: 模仿 時(shí)間: 2025-3-25 04:57 作者: Directed 時(shí)間: 2025-3-25 08:42 作者: 滋養(yǎng) 時(shí)間: 2025-3-25 14:01
Electric and Plug-In Hybrid Vehiclesfor clinical use. The possible value of drug combinations in the prevention of drug resistance will be covered in Chap. 16. Combinations of drugs may be considered under several headings, namely those that are complementary (e.g. against different stages of a parasite), combinations that are additiv作者: larder 時(shí)間: 2025-3-25 19:24
Vehicle Dynamics and Performance,ease have been addressed in various sections of this volume. We propose to discuss here a specific need which exists in malaria chemotherapy, that is for agents with prolonged activity — the so-called repository drugs. This therapeutic requirement has only in recent years received attention, and it 作者: Coma704 時(shí)間: 2025-3-25 22:04
Vehicle Dynamics and Performance, liver forms of . and . (. 1980). The clinical use of PQ as a causal prophylactic and therapeutic agent is, however, curtailed by its toxic side effects, especially for those patients having glucose-6-phosphate dehydrogenase-deficient erythrocytes (. et al. 1962). Much research has, therefore, been 作者: Gleason-score 時(shí)間: 2025-3-26 03:18
Electric, Hybrid, and Fuel Cell Vehiclesustomary to refer to them as derivatives of methanol and they are further classified according to their particular aromatic ring system, e.g. quinolinemethanols, phenanthrenemethanols, pyridinemethanols, etc. Since all of the arylaminoalcohols discussed in this chapter were developed in the US Army 作者: 作繭自縛 時(shí)間: 2025-3-26 04:19 作者: 壓艙物 時(shí)間: 2025-3-26 10:54 作者: 漸強(qiáng) 時(shí)間: 2025-3-26 15:16
https://doi.org/10.1007/978-3-642-54839-0 the most part, considered only those drugs or compounds that have shown an activity sufficient to focus broad attention upon them. Because established drugs are discussed elsewhere in this volume (see Chap. 1), much of the discussion in this chapter will centre on research and development efforts t作者: engender 時(shí)間: 2025-3-26 18:34
https://doi.org/10.1007/978-3-642-54839-0he classic drugs remains unclear. However, substantial knowledge has been collected on the parasite folic acid cycle (see Part I, Chap. 2) and on those structures which exert their antimalarial effects via its inhibition. Thus the sulphonamides and the so-called antifolates act on the synthesis of f作者: 偏離 時(shí)間: 2025-3-26 22:52 作者: 混沌 時(shí)間: 2025-3-27 04:13 作者: 好開(kāi)玩笑 時(shí)間: 2025-3-27 05:17
4-Aminoquinolinesganic chemistry (. and . 1966; . 1967). It was first prepared in 1934 by H. Andersag in the Elberfeld-Leverkusen laboratories of the I. G. Farbenindustrie, as part of a programme which included the synthesis of such important compounds as mepacrine, pentaquine, isopentaquine, pamaquine, primaquine, 作者: 錢財(cái) 時(shí)間: 2025-3-27 12:12 作者: 劇毒 時(shí)間: 2025-3-27 16:04 作者: Spina-Bifida 時(shí)間: 2025-3-27 20:10
Sulphonamides and Sulphones These are, mainly, the sulphonamides sulfamonomethoxine, sulfadoxine and sulfalene, the sulphone dapsone and, to some extent, also the derivatives of dapsone, diformyldapsone and acedapsone. Only the properties of the single drugs are discussed. (For those of the combinations with pyrimethamine and作者: 不發(fā)音 時(shí)間: 2025-3-27 22:52
Dihydrofolate Reductase Inhibitorsuanides synthesised as ring-opened analogues possessed good activity against . infections in chicks (. et al. 1945). Later, a group at Burroughs Wellcome who were testing various types of pyrimidines as inhibitors of nucleic acid synthesis pointed out a formal structural analogy between the most act作者: 草本植物 時(shí)間: 2025-3-28 02:20
Drug Combinationsfor clinical use. The possible value of drug combinations in the prevention of drug resistance will be covered in Chap. 16. Combinations of drugs may be considered under several headings, namely those that are complementary (e.g. against different stages of a parasite), combinations that are additiv作者: 迫擊炮 時(shí)間: 2025-3-28 10:18 作者: 黑豹 時(shí)間: 2025-3-28 14:04 作者: Filibuster 時(shí)間: 2025-3-28 15:18
Drugs with Quinine-like Actionustomary to refer to them as derivatives of methanol and they are further classified according to their particular aromatic ring system, e.g. quinolinemethanols, phenanthrenemethanols, pyridinemethanols, etc. Since all of the arylaminoalcohols discussed in this chapter were developed in the US Army 作者: OMIT 時(shí)間: 2025-3-28 22:20 作者: 社團(tuán) 時(shí)間: 2025-3-29 02:26 作者: 神經(jīng) 時(shí)間: 2025-3-29 03:46
4-Aminoquinolines and Mannich Bases the most part, considered only those drugs or compounds that have shown an activity sufficient to focus broad attention upon them. Because established drugs are discussed elsewhere in this volume (see Chap. 1), much of the discussion in this chapter will centre on research and development efforts t作者: 率直 時(shí)間: 2025-3-29 08:32 作者: Admonish 時(shí)間: 2025-3-29 13:07 作者: PAGAN 時(shí)間: 2025-3-29 19:20
Miscellaneous Compounds antiplasmodial activity is claimed, but which lie outside the main antimalarial series reviewed in the other chapters of this book. Most of the compounds described either have not been suitable for evaluation in man or have been insufficiently investigated for their activity in malaria to be defini作者: 自負(fù)的人 時(shí)間: 2025-3-29 21:08 作者: conduct 時(shí)間: 2025-3-30 01:40
Vehicle Dynamics and Performance,ts, especially for those patients having glucose-6-phosphate dehydrogenase-deficient erythrocytes (. et al. 1962). Much research has, therefore, been pursued in the hope of developing new 8-aminoquinoline derivatives possessing a higher therapeutic index.作者: 盤旋 時(shí)間: 2025-3-30 04:02
Cell Targeting of Primaquinets, especially for those patients having glucose-6-phosphate dehydrogenase-deficient erythrocytes (. et al. 1962). Much research has, therefore, been pursued in the hope of developing new 8-aminoquinoline derivatives possessing a higher therapeutic index.作者: 不出名 時(shí)間: 2025-3-30 09:38 作者: 不在灌木叢中 時(shí)間: 2025-3-30 14:52
Sulphonamides and Sulphones other inhibitors of dihydrofolic acid reductase, see this part, Chap. 6.) The sulphonamide probably best known, sulfadiazine, is included in most paragraphs as a reference, although it is not considered an antimalarial.作者: 敲詐 時(shí)間: 2025-3-30 20:33
Drug Combinationse but acting against the same stages and those that are synergistic. All have their place in the control of malaria. While this chapter is written within the context of “Novel Methods of Drug Development”, some of the older drug combinations will be referred to for the sake of completion and as a guide to future developments.作者: 做方舟 時(shí)間: 2025-3-30 21:35 作者: Assemble 時(shí)間: 2025-3-31 01:01
