標(biāo)題: Titlebook: Antiepileptic Drugs; Pharmacology and The Mervyn J. Eadie,Frank J. E. Vajda Book 1999 Springer-Verlag Berlin Heidelberg 1999 catecholamines [打印本頁(yè)] 作者: Abridge 時(shí)間: 2025-3-21 19:47
書(shū)目名稱(chēng)Antiepileptic Drugs影響因子(影響力)
作者: Stricture 時(shí)間: 2025-3-21 23:07 作者: 金桌活畫(huà)面 時(shí)間: 2025-3-22 01:01
https://doi.org/10.1007/978-3-7091-9962-6arbitone and its congeners, the succinimides, sulthiame and acetazolamide, and the bromides. The various oxazolidinediones (principally troxidone — trimetha-dione), formerly important for treating absence epilepsy, now seem to have almost completely disappeared from clinical use, though they are still employed in experimental laboratory studies.作者: GULLY 時(shí)間: 2025-3-22 08:37
Werkzeuge für die Werkstoffverarbeitung of action at the molecular level was unclear. The latter has now been elucidated, and considerable additional information has become available concerning the disposition, interactions and toxicity of the drug, mainly in humans, whilst its range of therapeutic uses has expanded. The present chapter deals chiefly with this newer information.作者: 抵制 時(shí)間: 2025-3-22 11:17 作者: 紀(jì)念 時(shí)間: 2025-3-22 13:15
https://doi.org/10.1007/978-3-662-31601-6ion may be a result of several mechanisms including effects on sodium and potassium channels, a novel interaction with the GABA. receptor and inhibition of the action of kainate on the kainate/AMPA subtype of glutamate receptor.作者: Accomplish 時(shí)間: 2025-3-22 19:31 作者: bioavailability 時(shí)間: 2025-3-22 21:46 作者: milligram 時(shí)間: 2025-3-23 01:28 作者: 固定某物 時(shí)間: 2025-3-23 08:22
Older Anticonvulsants Continuing in Use but with Limited Advance in Knowledge,arbitone and its congeners, the succinimides, sulthiame and acetazolamide, and the bromides. The various oxazolidinediones (principally troxidone — trimetha-dione), formerly important for treating absence epilepsy, now seem to have almost completely disappeared from clinical use, though they are still employed in experimental laboratory studies.作者: FIR 時(shí)間: 2025-3-23 11:21
Carbamazepine, of action at the molecular level was unclear. The latter has now been elucidated, and considerable additional information has become available concerning the disposition, interactions and toxicity of the drug, mainly in humans, whilst its range of therapeutic uses has expanded. The present chapter deals chiefly with this newer information.作者: 含鐵 時(shí)間: 2025-3-23 16:00
Gabapentin,ic profile, minimal propensity for drug interactions, and lack of demonstrable or reported idiosyncratic reactions to date, the drug may have advantages in the treatment of epilepsy, when used as add-on therapy.作者: 裹住 時(shí)間: 2025-3-23 20:26 作者: 史前 時(shí)間: 2025-3-23 23:31 作者: obtuse 時(shí)間: 2025-3-24 03:30
Book 1999volume the then available data on the topic of antiepileptic drugs were col- lated and analysed. Over the intervening years knowledge in this area has grown progressively. More new antiepileptic drugs than the total number of agents that were in common use 15 years ago have in the interval either co作者: 女上癮 時(shí)間: 2025-3-24 09:06 作者: dowagers-hump 時(shí)間: 2025-3-24 13:04
Epileptogenesis: Electrophysiology,referenced herein do point to the larger literature. Expectably, many of the essentials arise from experimental work in animals, but the ideas are usually supported by some specific studies in humans.作者: Incise 時(shí)間: 2025-3-24 16:48 作者: 尊重 時(shí)間: 2025-3-24 20:20
Eisenwerkstoffe und ihre Anwendung,enyltriazine compounds, which had weak antifolate properties, proved to be potent anticonvulsants. Lamotrigine was developed from these compounds, though neither short-term nor chronic lamotrigine therapy appears to be associated with significant changes in serum or red cell folate concentrations (. and . 1992).作者: landfill 時(shí)間: 2025-3-25 01:49
Cellular Actions of Antiepileptic Drugs, 1994 the manufacturer and the United States Federal Drug Administration recommended that, if clinically possible, patients be withdrawn from felbamate. Fortunately, the remaining newly developed antiepileptic drugs have been approved in many countries and are currently in use.作者: humectant 時(shí)間: 2025-3-25 04:14 作者: aquatic 時(shí)間: 2025-3-25 08:17 作者: MORT 時(shí)間: 2025-3-25 13:32
Werkzeuge für die Werkstoffverarbeitungers. Since then phenytoin has been one of the mainstays of seizure therapy. In 1968 . et al. reported success in the treatment of status epilepticus with high doses of phenytoin given intravenously. A water-soluble prodrug was developed in the 1980s to simplify the parenteral administration of phenytoin (see Sect. B on fosphenytoin, below).作者: Carbon-Monoxide 時(shí)間: 2025-3-25 19:02 作者: 吵鬧 時(shí)間: 2025-3-25 20:29 作者: 外露 時(shí)間: 2025-3-26 02:23
Phenytoin and Congeners,ers. Since then phenytoin has been one of the mainstays of seizure therapy. In 1968 . et al. reported success in the treatment of status epilepticus with high doses of phenytoin given intravenously. A water-soluble prodrug was developed in the 1980s to simplify the parenteral administration of phenytoin (see Sect. B on fosphenytoin, below).作者: 饑荒 時(shí)間: 2025-3-26 06:52
Vigabatrin,e in water but only slightly soluble in ethanol and methanol and is insoluble in hexane and toluene. It is a white to off-white crystalline solid with a melting point of 171°–177°C. Its molecular weight is 129.16 and the conversion factor (CF) is 7.75 (mg/l × CF = μmol/l).作者: Hemiplegia 時(shí)間: 2025-3-26 09:12
Tiagabine,Abbott Laboratories filed a new drug application for tiagabine with the Food and Drug Administration in the United States for its use as add-on therapy for partial seizures and the drug was approved September, 1997.作者: gonioscopy 時(shí)間: 2025-3-26 15:59
Book 1999 were previously. As well, more information is available concerning the natural history of human epilepsy, and this knowledge is important in making optimal use of the various agents that are now available. Therefore, it has seemed appropriate at this stage in the evolution of knowledge to produce a作者: Defense 時(shí)間: 2025-3-26 19:17
Manfred Wick,Wulf Pinggera,Paul Lehmannth, certain models can be used to study mechanisms of drug resistance in epilepsy. Sixth, in view of the possibility that chronic brain dysfunction, such as epilepsy, might lead to altered sensitivity to drug adverse effects, models involving epileptic animals are useful to study whether epileptogen作者: Coronary 時(shí)間: 2025-3-26 23:15 作者: Host142 時(shí)間: 2025-3-27 02:31
Manfred Wick,Wulf Pinggera,Paul Lehmannet the requirements of clinical pharmacokinetic or metabolic studies, while methods which meet these latter requirements may be inappropriate in terms of cost, speed or convenience in the therapeutic drug monitoring laboratory. While it is not possible in the space available to give a comprehensive 作者: Antioxidant 時(shí)間: 2025-3-27 08:30
0171-2004 and this knowledge is important in making optimal use of the various agents that are now available. Therefore, it has seemed appropriate at this stage in the evolution of knowledge to produce a978-3-642-64244-9978-3-642-60072-2Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 萬(wàn)靈丹 時(shí)間: 2025-3-27 13:08 作者: temperate 時(shí)間: 2025-3-27 15:19
Epileptogenesis: Biochemical Aspects, However, the marked heterogeneity of syndromes (up to 50) diagnosed as epilepsy makes it most unlikely that there is a singular biochemical disorder that results in epileptogenesis. Furthermore, seizures set in motion a cascade of complex molecular and genomic changes, including changes in gene exp作者: 閑蕩 時(shí)間: 2025-3-27 18:22
Measurement of Anticonvulsants and Their Metabolites in Biological Fluids,et the requirements of clinical pharmacokinetic or metabolic studies, while methods which meet these latter requirements may be inappropriate in terms of cost, speed or convenience in the therapeutic drug monitoring laboratory. While it is not possible in the space available to give a comprehensive 作者: 是貪求 時(shí)間: 2025-3-27 22:00 作者: Exterior 時(shí)間: 2025-3-28 03:25
Manfred Wick,Wulf Pinggera,Paul Lehmannconvulsant activity of a novel compound has been detected, animal models are used to evaluate the possible specific efficacies of the compound against different types of seizures or epilepsy. Third, animal models can be used to characterize the preclinical efficacy of novel compounds during chronic 作者: scrutiny 時(shí)間: 2025-3-28 10:19 作者: Bone-Scan 時(shí)間: 2025-3-28 11:09
Manfred Wick,Wulf Pinggera,Paul Lehmann defined as transient changes of behaviour due to the disordered, synchronous, and rhythmic firing of populations of central nervous system neurons (. 1994). These disorders of neuronal excitability can remain local or spread to other sites or engage all cortical regions simultaneously. Epileptogene作者: Axillary 時(shí)間: 2025-3-28 14:52 作者: obeisance 時(shí)間: 2025-3-28 20:59 作者: ALE 時(shí)間: 2025-3-28 23:20 作者: 最后一個(gè) 時(shí)間: 2025-3-29 07:05 作者: 入會(huì) 時(shí)間: 2025-3-29 09:09
Werkzeuge für die Werkstoffverarbeitungures in cats. In 1938 . and . reported that it provided effective treatment for chronic seizures, without sedation, in patients with convulsive disorders. Since then phenytoin has been one of the mainstays of seizure therapy. In 1968 . et al. reported success in the treatment of status epilepticus w作者: 碎石頭 時(shí)間: 2025-3-29 14:44 作者: Deadpan 時(shí)間: 2025-3-29 16:30 作者: Glossy 時(shí)間: 2025-3-29 19:55 作者: 與野獸博斗者 時(shí)間: 2025-3-30 02:42 作者: 感情 時(shí)間: 2025-3-30 06:15
https://doi.org/10.1007/3-540-29793-6c, sedative and antiepileptic activity and received marketing approval in 1960 (. et al. 1960). Although effective, the drug was noted to have significant toxicity and chemists then turned to synthesizing structural analogues in the hope of finding compounds with enhanced pharmacological activity an作者: 樣式 時(shí)間: 2025-3-30 09:52 作者: 浪蕩子 時(shí)間: 2025-3-30 14:42 作者: 運(yùn)氣 時(shí)間: 2025-3-30 17:14 作者: 擁護(hù)者 時(shí)間: 2025-3-30 22:20
https://doi.org/10.1007/978-3-662-31601-6 predicted from its chemistry; rather they were discovered by routine screening of various 1,2-benzisoxazole derivatives. Its formula is C.H.N.O.S, and its molecular weight is 212. It has a p.. of 9.66, so that its water solubility is dependent on the pH. Below a pH of 8, it has a solubility of only作者: 不如屎殼郎 時(shí)間: 2025-3-31 04:12
Antiepileptic Drugs978-3-642-60072-2Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: CRUC 時(shí)間: 2025-3-31 06:12
Grundlagen der Eisenwerkstoffe,atment for partial seizures, whether or not they became secondarily generalized, and for primary generalized tonic-clonic seizures. The estimated patient exposure to the drug currently exceeds 50,000 patient years. Oxcarbazepine is under active investigation in the United States.作者: 賭博 時(shí)間: 2025-3-31 12:13
https://doi.org/10.1007/3-540-29793-6c, sedative and antiepileptic activity and received marketing approval in 1960 (. et al. 1960). Although effective, the drug was noted to have significant toxicity and chemists then turned to synthesizing structural analogues in the hope of finding compounds with enhanced pharmacological activity and reduced toxicity.作者: ANT 時(shí)間: 2025-3-31 16:04
https://doi.org/10.1007/978-3-642-60072-2catecholamines; chemistry; clinical trial; cortex; drug; drug development; epilepsy; kinetics; neuropeptides作者: FLING 時(shí)間: 2025-3-31 21:07
978-3-642-64244-9Springer-Verlag Berlin Heidelberg 1999作者: anticipate 時(shí)間: 2025-4-1 00:15
Mervyn J. Eadie,Frank J. E. VajdaIncludes supplementary material: 作者: extract 時(shí)間: 2025-4-1 03:54
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/a/image/158543.jpg作者: Ostrich 時(shí)間: 2025-4-1 06:01
Oxcarbazepine,atment for partial seizures, whether or not they became secondarily generalized, and for primary generalized tonic-clonic seizures. The estimated patient exposure to the drug currently exceeds 50,000 patient years. Oxcarbazepine is under active investigation in the United States.作者: 競(jìng)選運(yùn)動(dòng) 時(shí)間: 2025-4-1 13:04
Benzodiazepines,c, sedative and antiepileptic activity and received marketing approval in 1960 (. et al. 1960). Although effective, the drug was noted to have significant toxicity and chemists then turned to synthesizing structural analogues in the hope of finding compounds with enhanced pharmacological activity and reduced toxicity.作者: EVICT 時(shí)間: 2025-4-1 16:29
Eisenwerkstoffe und ihre Anwendung,Valproate is a major and well established antiepileptic agent which is in contemporary widespread use in the treatment of the disorder, especially the generalized variety, for which it has become the drug of first choice. It also appears to be finding new uses in the management of a more extensive range of neurological and psychiatric disorders.作者: Constant 時(shí)間: 2025-4-1 19:59
Valproate,Valproate is a major and well established antiepileptic agent which is in contemporary widespread use in the treatment of the disorder, especially the generalized variety, for which it has become the drug of first choice. It also appears to be finding new uses in the management of a more extensive range of neurological and psychiatric disorders.作者: Focus-Words 時(shí)間: 2025-4-1 23:25
Classification of Epileptic Seizures and the Epilepsies and Drugs of Choice for Their Treatment,n describing individual seizures but also in enlarging the basis of fundamental knowledge by applying what was known of physiology and by inventing more advanced means of recording epileptic phenomena. Others proposed a classification, not of individual seizures, but of the conditions responsible fo作者: 抱怨 時(shí)間: 2025-4-2 03:14
Animal Models of Epilepsy and Epileptic Seizures,convulsant activity of a novel compound has been detected, animal models are used to evaluate the possible specific efficacies of the compound against different types of seizures or epilepsy. Third, animal models can be used to characterize the preclinical efficacy of novel compounds during chronic 作者: 重力 時(shí)間: 2025-4-2 09:37
