標題: Titlebook: Anticancer Drug Discovery and Development: Natural Products and New Molecular Models; Proceedings of the S Frederick A. Valeriote,Thomas H. [打印本頁] 作者: Racket 時間: 2025-3-21 19:24
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書目名稱Anticancer Drug Discovery and Development: Natural Products and New Molecular Models讀者反饋學科排名
作者: 模范 時間: 2025-3-21 22:13 作者: cardiovascular 時間: 2025-3-22 01:18 作者: 一罵死割除 時間: 2025-3-22 04:55
Novel Strategies for the Discovery of Plant-Derived Anticancer Agents,nts, terrestrial plants offer a unique, renewable resource for the discovery of potential new drugs and biological entities. The most pertinent question is how to find the proverbial needle (active compound) in the haystack (plant kingdom). Conservative estimates indicate that there are about 250,00作者: Pelago 時間: 2025-3-22 11:17
A Strategy for Identifying Novel Inhibitors of DNA Topoisomerase I,l role that these enzymes play in cellular processes such as DNA replication, transcription and recombination (2) suggests that they may constitute logical targets in the design of antineoplastic agents. In fact, several useful antitumor agents have now been shown to function, at least in part, via 作者: crucial 時間: 2025-3-22 15:28
Altromycins: A New Family of Antitumor Antibiotics-Discovery and Biological Evaluation,d antibiotics with activity against Gram positive bacteria and potent cytotoxic activity against a variety of tumor cell lines. This article describes the production, isolation, structural elucidation, mechanism of action, and biological characterization of these antibiotics which we have called Alt作者: Commonplace 時間: 2025-3-22 19:23
Suppression of Human Melanoma Metastasis in SCID Mice with Antibodies to the EGF-Receptor,able, particularly after metastasis has occurred. Among solid tumors, however, malignant melanoma is considered one of the more suitable candidates for immunotherapy. One of our goals was to develop a metastatic human melanoma model in mice that mimics clinical disease and furthermore, to demonstrat作者: 提升 時間: 2025-3-23 00:12 作者: 潛伏期 時間: 2025-3-23 04:13
Interferons in Cancer Therapy: From Clinical Trials to New Potentials in Anticancer Drug Discovery asses according to their acid stability. The first class which is acid-proof consists of 3 families; alpha, beta, and omega. The second class consists of interferon gamma which is not acid-proof (Table 1). Since the discovery and naming of Interferon by Isaacs and Lindenmann in 1957, Boehringer Inge作者: 售穴 時間: 2025-3-23 06:33
Microorganisms: Strategic Sources of Novel Antitumor Agents,mes, growth regulators, enzyme inhibitors, and pharmacologically-active metabolites (1,2). Of the many compounds produced, however, the antibiotics have been most closely identified with microorganisms because of their clinical and commercial success. Selman Waksman (3) defined antibiotic as “a comp作者: 失敗主義者 時間: 2025-3-23 11:23
The Therapeutic Potential of Novel Pure Antiestrogens,n “Nolvadex”* [tamoxifen: ICI 46,474]. Effective palliation of both advanced and primary breast cancer is achieved without significant side effects by daily oral administration of “Nolvadex” (1,2). In view of this experience, it is reasonable to question whether there is either a clinical need, or p作者: 斗志 時間: 2025-3-23 15:55
Bropirimine, a Small-Molecule Biological Response Modifier and an Effective Antitumor Agent, agent is currently under Phase II clinical trial for its antitumor efficacy. In 1976, a 6-alkylpyrimidinone [2-amino-5-bromo-6-methyl-4(3H)-pyrimidinone, ABMP] was reported to induce circulating interferon (IFN) in animals upon oral (po) or intraperitoneal (ip) administration (3,4). Further researc作者: Foment 時間: 2025-3-23 21:57 作者: 發(fā)炎 時間: 2025-3-23 23:16 作者: 紀念 時間: 2025-3-24 02:31 作者: 期滿 時間: 2025-3-24 07:05 作者: FLAIL 時間: 2025-3-24 13:18
Anticancer Drug Discovery and Development: Natural Products and New Molecular ModelsProceedings of the S作者: Vaginismus 時間: 2025-3-24 15:55 作者: FILTH 時間: 2025-3-24 19:34 作者: arousal 時間: 2025-3-24 23:46
or bringing together the principal groups involved in bothdiscovering and developing new approaches to the treatment of cancer.This Second Symposium emphasized the types of materials beingdiscovered and their therapeutic activity. This is especially evidentin the natural product discovery programs, 作者: 發(fā)牢騷 時間: 2025-3-25 05:50 作者: SPECT 時間: 2025-3-25 10:33
https://doi.org/10.1007/978-3-662-38422-0 daily oral administration of “Nolvadex” (1,2). In view of this experience, it is reasonable to question whether there is either a clinical need, or pharmacological rationale, for novel antiestrogens. In our review of these questions, the answer was affirmative in both respects and led to the definition of a new drug target.作者: indicate 時間: 2025-3-25 13:48 作者: 芭蕾舞女演員 時間: 2025-3-25 17:49
Discovery of Natural Products from Microalgae and Marine Organisms,screening or a subsequence of synthesis of analogs of lead drugs (Table 1). Specifically, the discovery of cytotoxic agents from natural sources has had a rich and fruitful past with the identification of agents such as vincristine and taxol from plants and a number of antibiotics such as adriamycin from fermentations.作者: 單調(diào)性 時間: 2025-3-25 21:22
The Therapeutic Potential of Novel Pure Antiestrogens, daily oral administration of “Nolvadex” (1,2). In view of this experience, it is reasonable to question whether there is either a clinical need, or pharmacological rationale, for novel antiestrogens. In our review of these questions, the answer was affirmative in both respects and led to the definition of a new drug target.作者: Spinous-Process 時間: 2025-3-26 00:14 作者: BLOT 時間: 2025-3-26 05:52
Novel Strategies for the Discovery of Plant-Derived Anticancer Agents,0 species of flowering plants on this planet, of which it is estimated that 155,000 are found in the tropics (1), consequently, a rational strategy for drug discovery is required, since it is unrealistic to believe that all plants can be investigated biologically.作者: MIRE 時間: 2025-3-26 11:50 作者: Genetics 時間: 2025-3-26 13:08
Microorganisms: Strategic Sources of Novel Antitumor Agents,ound produced by a microorganism which kills or inhibits the growth of other microorganisms in low concentrations”. Now, the definition seems to extend to any bioactive compound produced by microorganisms.作者: Crater 時間: 2025-3-26 16:58
Prozessmodell des Rezeptionsmarktes,0 species of flowering plants on this planet, of which it is estimated that 155,000 are found in the tropics (1), consequently, a rational strategy for drug discovery is required, since it is unrealistic to believe that all plants can be investigated biologically.作者: 我還要背著他 時間: 2025-3-26 22:53
Zusammenfassung der Ergebnisse und Fazit,e that this model is useful for studying approaches to immunotherapy. We describe here the effects of antibody therapy in a model for metastasizing human melanoma, using monoclonal antibodies directed against the EGF-receptor.作者: 不透明 時間: 2025-3-27 01:37 作者: Incisor 時間: 2025-3-27 09:00 作者: Atmosphere 時間: 2025-3-27 09:27
Modelle von Publikumsverhalten,mage resulting in aberrant gene expression which is a multi-step process (4). Chromosomal analyses of tumor cells have revealed many abnormal karyotypes with metastases as the most aberrant. Most cancers exhibit some cytogenetic defect (5).作者: 有抱負者 時間: 2025-3-27 17:23
Eingliederung als Rechtfertigungsarbeittoposide inhibits the activity of topo II . (9) and causes extensive DNA fragmentation in the presence of purified calf thymus topo II (10,11) with the enzyme attached to the 5′ phosphoryl end of the broken DNA strand (10); overexpression of plasmid-borne topo II in yeast leads to etoposide hypersensitivity (12).作者: 墻壁 時間: 2025-3-27 18:17
Discovery of Naturally Occurring Antitumor Agents,develop other novel approaches to complement the other cytotoxicity-based approach. Our National Cooperative Natural Product Drug Discovery Group has designed three mechanism-based screening systems to exploit (a) multidrug resistance, (b) protein kinase C, and (c) protein tyrosine kinase.作者: gnarled 時間: 2025-3-28 01:46 作者: 雄偉 時間: 2025-3-28 05:38 作者: 秘密會議 時間: 2025-3-28 08:14 作者: 在前面 時間: 2025-3-28 12:57 作者: 過份艷麗 時間: 2025-3-28 17:17 作者: osteocytes 時間: 2025-3-28 21:04
Interferons in Cancer Therapy: From Clinical Trials to New Potentials in Anticancer Drug Discovery iotechnological production, as well as experimental and clinical oncology. In the last few years, interferons have come of age and have found a respectable position among the most prominent new drugs.作者: Flawless 時間: 2025-3-29 01:40 作者: 忙碌 時間: 2025-3-29 06:47 作者: 格言 時間: 2025-3-29 08:19
Andreas Maercker,Matthias SchützwohlMurine, human and chimeric monoclonal antibodies (MAbs) with specificity for human tumor antigens have achieved only limited success in the diagnosis and treatment of cancer (1–7). More promise is offered by the use of MAbs as carriers of drugs and toxins for tumor destruction and for delivery of radionuclides for tumor imaging and therapy (8–17).作者: accomplishment 時間: 2025-3-29 14:35
https://doi.org/10.1007/978-3-642-49709-4In the late 1960s, a crude alcohol extract from the bark of the Pacific Yew, ., was revealed to be cytotoxic . in the National Cancer Institute screening program (1,2). That extract’s principle, taxol, was isolated and characterized in 1971 by Wani et al (1).作者: misanthrope 時間: 2025-3-29 16:27 作者: 鐵砧 時間: 2025-3-29 20:35
Selection and Manipulation of Immunoglobulins for Radionuclide Delivery,Murine, human and chimeric monoclonal antibodies (MAbs) with specificity for human tumor antigens have achieved only limited success in the diagnosis and treatment of cancer (1–7). More promise is offered by the use of MAbs as carriers of drugs and toxins for tumor destruction and for delivery of radionuclides for tumor imaging and therapy (8–17).作者: Latency 時間: 2025-3-30 03:51 作者: 脫水 時間: 2025-3-30 06:42 作者: 領袖氣質(zhì) 時間: 2025-3-30 11:25
Prozessmodell des Rezeptionsmarktes,covery Group (NCNPDDG) was organized to access a relatively understudied source of natural product leads: marine microbes and sessile marine organisms. We present here an overview of the structure of our group, a brief outline of our overall goals and strategy, and a summary of the advances we have made toward those goals.作者: 獨輪車 時間: 2025-3-30 14:33
Prozessmodell des Rezeptionsmarktes,l role that these enzymes play in cellular processes such as DNA replication, transcription and recombination (2) suggests that they may constitute logical targets in the design of antineoplastic agents. In fact, several useful antitumor agents have now been shown to function, at least in part, via inhibition of DNA topoisomerase II (3,4).作者: 減震 時間: 2025-3-30 18:56 作者: irreparable 時間: 2025-3-30 23:42 作者: SMART 時間: 2025-3-31 03:48 作者: COWER 時間: 2025-3-31 05:29
Prozessmodell des Rezeptionsmarktes,covery Group (NCNPDDG) was organized to access a relatively understudied source of natural product leads: marine microbes and sessile marine organisms. We present here an overview of the structure of our group, a brief outline of our overall goals and strategy, and a summary of the advances we have 作者: ingenue 時間: 2025-3-31 12:47 作者: JECT 時間: 2025-3-31 14:24
Prozessmodell des Rezeptionsmarktes,l role that these enzymes play in cellular processes such as DNA replication, transcription and recombination (2) suggests that they may constitute logical targets in the design of antineoplastic agents. In fact, several useful antitumor agents have now been shown to function, at least in part, via 作者: Polydipsia 時間: 2025-3-31 20:53 作者: hallow 時間: 2025-3-31 22:29
Zusammenfassung der Ergebnisse und Fazit,able, particularly after metastasis has occurred. Among solid tumors, however, malignant melanoma is considered one of the more suitable candidates for immunotherapy. One of our goals was to develop a metastatic human melanoma model in mice that mimics clinical disease and furthermore, to demonstrat作者: arabesque 時間: 2025-4-1 03:59
Modelle von Publikumsverhalten,imulated by a study of viral oncogenes (1) and have centered around the activation of proto-oncogenes, which code for proteins that are involved in the signal transduction events that modulate normal cellular growth and differentiation. More that one hundred normal cellular proto-oncogenes are now k作者: hermetic 時間: 2025-4-1 06:00
https://doi.org/10.1007/978-3-642-93689-0asses according to their acid stability. The first class which is acid-proof consists of 3 families; alpha, beta, and omega. The second class consists of interferon gamma which is not acid-proof (Table 1). Since the discovery and naming of Interferon by Isaacs and Lindenmann in 1957, Boehringer Inge作者: Between 時間: 2025-4-1 13:54
https://doi.org/10.1007/978-3-662-38422-0mes, growth regulators, enzyme inhibitors, and pharmacologically-active metabolites (1,2). Of the many compounds produced, however, the antibiotics have been most closely identified with microorganisms because of their clinical and commercial success. Selman Waksman (3) defined antibiotic as “a comp
