標(biāo)題: Titlebook: Antibody-Drug Conjugates and Cellular Metabolic Dynamics; Shuqing Chen,Jinbiao Zhan Book 2023 The Editor(s) (if applicable) and The Author [打印本頁] 作者: 兩邊在擴(kuò)散 時(shí)間: 2025-3-21 17:03
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書目名稱Antibody-Drug Conjugates and Cellular Metabolic Dynamics讀者反饋學(xué)科排名
作者: isotope 時(shí)間: 2025-3-21 21:37
Relationship Between Target and Specific Action of Antibody-Drug Conjugates,ects. A new type of entigen should be digged and developed for future antibody-based therapies. In this chapter, we discuss tumor-associated antigen, tumor-specific antigens on cell membrane, and several mutant peptides MHC I for de novo antibody-based drug antigen research.作者: SPURN 時(shí)間: 2025-3-22 02:04 作者: Assignment 時(shí)間: 2025-3-22 08:02 作者: 航海太平洋 時(shí)間: 2025-3-22 08:54
ates ananlysis.Introduce of new thoughts on more specific taThis book summarizes the related research achievements in Antibody-drug conjugates (ADCs)?and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and 作者: interior 時(shí)間: 2025-3-22 15:53
Einführung innovativer Systemgesch?ftee antigens which are expressed only on tumor cells. As one of crucial component, linkers such as cleavable linkers and noncleavable linkers have been explored. Finally, the highly effective payloads including tubulin inhibitors and DNA-damaging antibiotics have been discussed.作者: 可商量 時(shí)間: 2025-3-22 19:41
https://doi.org/10.1007/978-3-86226-389-9arly, the process of internalization and intracellular trafficking is thought to be crucial and need to be fully elucidated. Here, the internalization mechanism of ADC, including endocytosis pathways, intracellular processing and actions of ADC will be discussed.作者: WAG 時(shí)間: 2025-3-23 00:45
https://doi.org/10.1007/978-3-662-48505-7d making its properties more predictable. We focused on the commonly used site-directed conjugation strategies including engineered cysteine conjugation, Sortase A mediated conjugation and enzyme-chemical conjugation?in this chapter. In addition, we introduced a method for identifying conjugation sites by mass spectrometry.作者: bioavailability 時(shí)間: 2025-3-23 03:26
https://doi.org/10.1007/978-3-322-83953-4y of ADCs and their dissociation of small molecules in vivo. It is necessary to determine the DAR of ADCs. This chapter describes some methods for the DAR analysis, including reversed phase high performance liquid chromatography (RP-HPLC), hydrophobic interaction chromatography (HIC) and liquid chromatography-mass spectrometry (LC-MS).作者: 初學(xué)者 時(shí)間: 2025-3-23 07:02 作者: 自負(fù)的人 時(shí)間: 2025-3-23 11:36
Antibody-Drug Conjugates: Basic Concepts and Structures,e antigens which are expressed only on tumor cells. As one of crucial component, linkers such as cleavable linkers and noncleavable linkers have been explored. Finally, the highly effective payloads including tubulin inhibitors and DNA-damaging antibiotics have been discussed.作者: rectum 時(shí)間: 2025-3-23 16:34
The Internalization and Intracellular Trafficking of ADCs,arly, the process of internalization and intracellular trafficking is thought to be crucial and need to be fully elucidated. Here, the internalization mechanism of ADC, including endocytosis pathways, intracellular processing and actions of ADC will be discussed.作者: 箴言 時(shí)間: 2025-3-23 21:16 作者: 流浪 時(shí)間: 2025-3-23 23:21
Determination of Drug-to-Antibody Ratio of ADCs,y of ADCs and their dissociation of small molecules in vivo. It is necessary to determine the DAR of ADCs. This chapter describes some methods for the DAR analysis, including reversed phase high performance liquid chromatography (RP-HPLC), hydrophobic interaction chromatography (HIC) and liquid chromatography-mass spectrometry (LC-MS).作者: POWER 時(shí)間: 2025-3-24 05:57
Pharmacokinetic Study of Antibody-Drug Conjugates,f ADCs is the prerequisite for a thorough understanding the responses to ADCs. In this chapter, several technologies for analyzing the pharmacokinetic properties of ADCs are described, and a novel strategy is proposed by integrating the advantages of some technologies to evaluate metabolism of ADCs more accurately.作者: cliche 時(shí)間: 2025-3-24 10:11
Forschungsgruppe Konsum und Verhaltenects. A new type of entigen should be digged and developed for future antibody-based therapies. In this chapter, we discuss tumor-associated antigen, tumor-specific antigens on cell membrane, and several mutant peptides MHC I for de novo antibody-based drug antigen research.作者: 未完成 時(shí)間: 2025-3-24 13:38 作者: 有權(quán) 時(shí)間: 2025-3-24 17:38 作者: Erythropoietin 時(shí)間: 2025-3-24 19:18
Mitbestimmungsrecht des Betriebsratespharmacokinetic process of ADCs when these molecules are administered into blood system. At last, we introduced some commonly used detection methods that enable researchers to trace the metabolites after metabolization happening.作者: 橫截,橫斷 時(shí)間: 2025-3-25 02:50
Distribution and Metabolism of Antibody-Drug Conjugates,pharmacokinetic process of ADCs when these molecules are administered into blood system. At last, we introduced some commonly used detection methods that enable researchers to trace the metabolites after metabolization happening.作者: Crater 時(shí)間: 2025-3-25 04:27 作者: endoscopy 時(shí)間: 2025-3-25 11:05 作者: 流利圓滑 時(shí)間: 2025-3-25 12:57
Antibody-Drug Conjugates and Cellular Metabolic Dynamics作者: Headstrong 時(shí)間: 2025-3-25 16:59 作者: Junction 時(shí)間: 2025-3-26 00:04 作者: 下垂 時(shí)間: 2025-3-26 00:34 作者: Detain 時(shí)間: 2025-3-26 07:53
Forschungsgruppe Konsum und Verhaltenother antibody derivatives all performed benign anti-tumor effects in clinical treatment, which make these therapies a promising future. However, these antibody-based agents all target tumor associated antigens (TAAs) while tumor specific antigens (TSAs), which brings drug resistance and adverse eff作者: CAND 時(shí)間: 2025-3-26 09:02 作者: inspiration 時(shí)間: 2025-3-26 15:55
https://doi.org/10.1007/978-3-86226-389-9egradation and payload is released to target intracellular compartments to exert the anti-cancer effect. Considering that ADC takes effect intracellularly, the process of internalization and intracellular trafficking is thought to be crucial and need to be fully elucidated. Here, the internalization作者: 歡笑 時(shí)間: 2025-3-26 19:26
Mitbestimmungsrecht des Betriebsratesacy. During drug development, it is crucial for researchers to fully understand the metabolites and distribution of antibody-drug conjugates in circulation in human body, the data of which could be used to further optimize the drug design and to further improve the efficacy in clinical applications.作者: 多樣 時(shí)間: 2025-3-26 23:28 作者: expdient 時(shí)間: 2025-3-27 04:18 作者: 配置 時(shí)間: 2025-3-27 05:56
https://doi.org/10.1007/978-3-662-48505-7f a determined number of drugs to a determined site of the antibody, ensuring consistency between batches, minimizing the heterogeneity of the ADCs and making its properties more predictable. We focused on the commonly used site-directed conjugation strategies including engineered cysteine conjugati作者: neutral-posture 時(shí)間: 2025-3-27 12:14 作者: 樹上結(jié)蜜糖 時(shí)間: 2025-3-27 14:00 作者: organism 時(shí)間: 2025-3-27 20:09 作者: Peculate 時(shí)間: 2025-3-27 23:14
http://image.papertrans.cn/a/image/158484.jpg作者: 返老還童 時(shí)間: 2025-3-28 02:35
https://doi.org/10.1007/978-981-19-5638-6Antibody-drug conjugates; Cellular Metabolic Dynamics; Cellular internalization; Intracellular traffick作者: 刪除 時(shí)間: 2025-3-28 07:51 作者: 愛哭 時(shí)間: 2025-3-28 10:35
Application of Antibody Fragments in ADCs,rized antibodies not only retain the specificity and affinity of total antibody, but also have faster tissue penetration and relatively short half-life, which can effectively avoid off-target toxicity. Therefore, the miniaturization of ADC is an effective method to solve the limitation of traditional ADC drugs.作者: 安定 時(shí)間: 2025-3-28 15:18 作者: 含糊 時(shí)間: 2025-3-28 21:16
Relationship Between Target and Specific Action of Antibody-Drug Conjugates,other antibody derivatives all performed benign anti-tumor effects in clinical treatment, which make these therapies a promising future. However, these antibody-based agents all target tumor associated antigens (TAAs) while tumor specific antigens (TSAs), which brings drug resistance and adverse eff作者: GOAT 時(shí)間: 2025-3-29 01:33 作者: saturated-fat 時(shí)間: 2025-3-29 04:20 作者: Pulmonary-Veins 時(shí)間: 2025-3-29 08:58
Distribution and Metabolism of Antibody-Drug Conjugates,acy. During drug development, it is crucial for researchers to fully understand the metabolites and distribution of antibody-drug conjugates in circulation in human body, the data of which could be used to further optimize the drug design and to further improve the efficacy in clinical applications.
