標(biāo)題: Titlebook: Antibody Glycosylation; Marija Pezer Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature [打印本頁(yè)] 作者: 壓榨機(jī) 時(shí)間: 2025-3-21 19:32
書(shū)目名稱(chēng)Antibody Glycosylation影響因子(影響力)
作者: parsimony 時(shí)間: 2025-3-21 21:55
Lectin and Liquid Chromatography-Based Methods for Immunoglobulin (G) Glycosylation Analysisiated with different diseases and show a promising biomarker potential for diagnosis and prognosis of disease advancement. On the other hand, therapeutic biomolecules based on structural and functional features of Igs demand stringent quality control during the production process to ensure their saf作者: clarify 時(shí)間: 2025-3-22 03:24 作者: 漂亮 時(shí)間: 2025-3-22 07:49 作者: 加劇 時(shí)間: 2025-3-22 12:48
Automation of Immunoglobulin Glycosylation Analysisntial for both the optimization of glycosylation in the biopharmaceutical industry as well as for the advancement of clinical diagnostics based on glycosylation biomarkers. We will use this chapter to review the sample preparation processes that have been used on liquid-handling robots to obtain hig作者: –scent 時(shí)間: 2025-3-22 13:14 作者: Middle-Ear 時(shí)間: 2025-3-22 17:32 作者: CHASE 時(shí)間: 2025-3-22 21:19
Genetic Regulation of Immunoglobulin G Glycosylationy means of heritability, linkage and genome-wide association studies (GWAS). Unlike the synthesis of proteins, .-glycosylation biosynthesis is not a template-driven process, but rather a complex process regulated by both genetic and environmental factors. Current heritability studies have shown that作者: Sedative 時(shí)間: 2025-3-23 02:49 作者: 臨時(shí)抱佛腳 時(shí)間: 2025-3-23 08:46
Immunoglobulin G Glycosylation?Changes in Aging and Other Inflammatory Conditions297 (Asn.) of IgG heavy chains is decorated by a diantennary glycan bearing a number of galactose and sialic acid residues on the branches ranging from 0 to 2. In addition, the structure can present core-linked fucose and/or a bisecting GlcNAc. In many inflammatory and autoimmune conditions, as well作者: 事與愿違 時(shí)間: 2025-3-23 13:28 作者: 支形吊燈 時(shí)間: 2025-3-23 17:49
Sweet Rules: Linking Glycosylation to Antibody Functionlasting immunity. Moreover, antibodies have become the most widely used platform for developing novel therapies against cancer and autoimmunity, requiring an in-depth understanding of how antibodies mediate their activity in vivo and which factors modulate pro- or anti-inflammatory antibody activiti作者: 準(zhǔn)則 時(shí)間: 2025-3-23 20:59
Immunoglobulin G Glycosylation in Diseasesnant, and other diseases. This chapter contains an updated catalog of over 140 studies within which IgG glycosylation analysis was performed in a disease setting. Since the composition of IgG glycans is known to modulate its effector functions, it is suggested that a changed IgG glycosylation patter作者: 絕種 時(shí)間: 2025-3-23 23:33
Immunoglobulin A Glycosylation and Its Role in Diseaseorms of IgA. The production of IgA rivals all other immunoglobulin isotypes. The large quantities of IgA reflect the fundamental roles it plays in immune defense, protecting vulnerable mucosal surfaces against invading pathogens. SIgA dominates mucosal surfaces, whereas IgA in circulation is predomi作者: Matrimony 時(shí)間: 2025-3-24 02:21 作者: 追逐 時(shí)間: 2025-3-24 10:15 作者: 胰臟 時(shí)間: 2025-3-24 14:24
Die astronomischen Instrumente,rities require that the structure of a potential mAb drug product is comprehensively characterized employing state-of-the-art orthogonal analytical technologies; the PTM profile may define a set of critical quality attributes (CQAs) for the drug product that must be maintained, employing quality by 作者: dysphagia 時(shí)間: 2025-3-24 17:21 作者: 擔(dān)憂(yōu) 時(shí)間: 2025-3-24 20:02 作者: 嘮叨 時(shí)間: 2025-3-24 23:33
Formen und Methoden des Sprachaufbaueshlighting possible difficulties and pitfalls. The application section describes the detailed characterization of .-glycosylation, utilizing multiplexed CGE with laser-induced fluorescence detection (xCGE-LIF). Besides a comprehensive overview on antibody glycosylation by comparing species-specific I作者: 來(lái)自于 時(shí)間: 2025-3-25 04:16
Formen und Methoden des Sprachaufbauesth developing and using automated platforms for sample preparation. Finally, the future outlook for the automation of glycomics will be discussed along with a projected impact on the field in general.作者: 使腐爛 時(shí)間: 2025-3-25 08:17
Einführung in die symbolische Logik a cell. Thus, glycans are immensely versatile encoders of multicellular life. Yet, glycans do not represent a random collection of unpredictable structures but rather, a collection of predetermined but still dynamic entities that are present at defined quantities in each glycosylation site of a giv作者: 無(wú)瑕疵 時(shí)間: 2025-3-25 13:58
Einführung in die synoptische Wetteranalyseegions have so far been robustly associated with IgG .-glycosylation, discovering associations with genes encoding glycosyltransferases, but also transcription factors, co-factors, membrane transporters and other genes with no apparent role in IgG glycosylation. Further computational analyses have s作者: Eviction 時(shí)間: 2025-3-25 19:54 作者: intoxicate 時(shí)間: 2025-3-25 20:02
https://doi.org/10.1007/978-3-322-85539-8 therapy and the initiation of clinical testing of highly sialylated anti-inflammatory antibodies the proof-of-concept that understanding antibody glycosylation can lead to clinical innovation has been provided. The focus of this review is to summarize recent insights into how antibody glycosylation作者: Omniscient 時(shí)間: 2025-3-26 01:41 作者: ICLE 時(shí)間: 2025-3-26 07:42
https://doi.org/10.1007/978-3-662-02033-3y, the chemoenzymatic glycoengineering method that allows for the transfer of structurally defined oligosaccharides to Asn-linked GlcNAc residues with glycosynthase has been developed for remodeling of IgG-Fc oligosaccharides with high efficiency and flexibility. Additionally, various glycoengineeri作者: Hippocampus 時(shí)間: 2025-3-26 11:58 作者: 不公開(kāi) 時(shí)間: 2025-3-26 15:08 作者: Individual 時(shí)間: 2025-3-26 19:59
Mass Spectrometry-Based Methods for Immunoglobulin G ,-Glycosylation Analysisterature omitting excessive theoretical frameworks. Finally, selected highly popular methodologies in IgG glycoanalytics such as liquid chromatography–mass spectrometry and matrix-assisted laser desorption ionization are discussed more thoroughly yet in simple terms making this text a practical star作者: 運(yùn)氣 時(shí)間: 2025-3-26 22:48 作者: Hyaluronic-Acid 時(shí)間: 2025-3-27 01:22 作者: 全部 時(shí)間: 2025-3-27 08:08 作者: Hirsutism 時(shí)間: 2025-3-27 12:17
Genetic Regulation of Immunoglobulin G Glycosylationegions have so far been robustly associated with IgG .-glycosylation, discovering associations with genes encoding glycosyltransferases, but also transcription factors, co-factors, membrane transporters and other genes with no apparent role in IgG glycosylation. Further computational analyses have s作者: FATAL 時(shí)間: 2025-3-27 16:43
Immunoglobulin G Glycosylation?Changes in Aging and Other Inflammatory Conditionslow-grade, chronic, asymptomatic inflammatory state which, in the case of aging, is known as inflammaging. Glycomic alterations associated with inflammatory diseases often precede disease onset and follow remission. The aberrantly glycosylated IgG glycans associated with inflammation and aging can s作者: Criteria 時(shí)間: 2025-3-27 21:39 作者: muster 時(shí)間: 2025-3-28 01:47
Immunoglobulin A Glycosylation and Its Role in Diseasetailed characterization of IgA glycosylation, including its diverse range of heterogeneity, is of emerging interest. We provide an overview of the glycosylation observed for each subclass and molecular form of IgA as well as the range of heterogeneity for each site of glycosylation. In many ways, th作者: Brain-Waves 時(shí)間: 2025-3-28 03:11 作者: Retrieval 時(shí)間: 2025-3-28 10:00
1664-431X as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengin978-3-030-76914-7978-3-030-76912-3Series ISSN 1664-431X Series E-ISSN 2504-3692 作者: asthma 時(shí)間: 2025-3-28 12:45
https://doi.org/10.1007/978-3-030-76912-3Immunoglobulin; Ig(G) glycosylation; Posttranslational modifications; Glycoanalytics; Biomarker; Immunoth作者: Middle-Ear 時(shí)間: 2025-3-28 16:10 作者: 熱情的我 時(shí)間: 2025-3-28 20:45 作者: 變異 時(shí)間: 2025-3-28 23:29 作者: endoscopy 時(shí)間: 2025-3-29 06:56
Die astronomischen Instrumente, indications. Full-length IgG mAbs are large proteins that are subject to multiple posttranslational modifications (PTMs) during biosynthesis, purification, or storage, resulting in micro-heterogeneity. The production of recombinant mAbs in nonhuman cell lines may result in loss of structural fideli作者: GLUE 時(shí)間: 2025-3-29 08:32
https://doi.org/10.1007/978-3-662-59054-6iated with different diseases and show a promising biomarker potential for diagnosis and prognosis of disease advancement. On the other hand, therapeutic biomolecules based on structural and functional features of Igs demand stringent quality control during the production process to ensure their saf作者: 象形文字 時(shí)間: 2025-3-29 11:24 作者: 分發(fā) 時(shí)間: 2025-3-29 16:46 作者: Throttle 時(shí)間: 2025-3-29 23:29 作者: FLUSH 時(shí)間: 2025-3-30 03:12
Einführung in die symbolische Logik used in high-throughput settings, especially for the glycomic characterization of IgG. A collection of these tools, and the databases they rely on, are presented in this chapter. Specific applications are detailed in examples of immunoglobulin glycomics and glycoproteomics data processing workflows作者: MEEK 時(shí)間: 2025-3-30 06:47 作者: Somber 時(shí)間: 2025-3-30 09:27
Einführung in die synoptische Wetteranalysey means of heritability, linkage and genome-wide association studies (GWAS). Unlike the synthesis of proteins, .-glycosylation biosynthesis is not a template-driven process, but rather a complex process regulated by both genetic and environmental factors. Current heritability studies have shown that作者: arabesque 時(shí)間: 2025-3-30 16:06
Einführung in die synoptische Wetteranalyseseases, but also during a healthy life of an individual. Currently, there is limited knowledge of factors that alter IgG glycosylation in the healthy state and factors involved in specific IgG glycosylation patterns associated with pathophysiology. Genetic background plays an important role, but epi作者: Hamper 時(shí)間: 2025-3-30 17:18 作者: 紅腫 時(shí)間: 2025-3-30 22:38
Wilhelm Bertelsmann,Fritz Schusterne-tune effector functions. Mechanisms regulating IgG Fc glycans remain poorly understood. Changes accompanying menarche, menopause, and pregnancy have long implicated hormonal factors. Intervention studies now confirm that estrogens enhance IgG Fc galactosylation, in females and also in males, defi作者: 漫不經(jīng)心 時(shí)間: 2025-3-31 01:31
https://doi.org/10.1007/978-3-322-85539-8lasting immunity. Moreover, antibodies have become the most widely used platform for developing novel therapies against cancer and autoimmunity, requiring an in-depth understanding of how antibodies mediate their activity in vivo and which factors modulate pro- or anti-inflammatory antibody activiti
