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標(biāo)題: Titlebook: Animals and Alternatives in Toxicology; Present Status and F Michael Balls (Professor of Medical Cell Biology), Textbook 1991Latest edition [打印本頁(yè)]

作者: Ford    時(shí)間: 2025-3-21 16:40
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作者: gait-cycle    時(shí)間: 2025-3-21 23:59
Genotoxicity Testing,us prevent this disease with its vast social, human and economic costs (1). Whilst the disease has been recognised for many centuries, we are no nearer to making significant inroads into improving a patient’s prognosis for the majority of solid tumours, so cancer prevention should be a major goal.
作者: Ambulatory    時(shí)間: 2025-3-22 02:15
Alternative Methods and Their Application in Neurotoxicity Testing,se (1). Up to 1,000 new chemicals enter commerce each year, so it is impossible for populations of living organisms, including man, to avoid exposure to chemicals in some form or another. The existence of this extensive chemical universe, plus the fact that some chemicals are highly toxic to biologi
作者: blithe    時(shí)間: 2025-3-22 07:09
The Future of Alternative Approaches in Reproductive Toxicity Testing,ttention was given to compliance with the Three Rs in current testing methods and the achievement of reduction, refinement and replacement in animal testing by both current methods and research development. This report will comprise three sections covering regulatory aspects, . and . prescreens, and
作者: 攀登    時(shí)間: 2025-3-22 08:58

作者: 增減字母法    時(shí)間: 2025-3-22 13:47
The Development, Validation and Acceptance of , Toxicity Tests,ests for mutagenicity (2, 3) and for biologically-active mineral dusts (4), it was difficult to find any collaborative interlaboratory attempts to establish the reliability and usefulness of . methods in toxicity testing (5). For this reason, FRAME established a research programme, which at that tim
作者: 中世紀(jì)    時(shí)間: 2025-3-22 19:01
Future Developments in , Methodology, toxicology and in the search for . methods for predicting the toxicological effects of chemicals and products. Major research programmes are under way in the industrial and academic research laboratories of many countries, and a number of . methods are already in use as screening tests. Such screen
作者: 鑒賞家    時(shí)間: 2025-3-22 21:27

作者: Banquet    時(shí)間: 2025-3-23 04:11
Economic Ideas You Should Forgetpotentially centrally-active and neurotoxic xenobiotics are continually entering the development ‘pipeline’ in industry. To identify neurotoxic chemicals and then legislate their use in society, previous and current emphasis is on the use of . methodology. The purpose of this review is to identify t
作者: 羞辱    時(shí)間: 2025-3-23 07:29
Michael Balls (Professor of Medical Cell Biology),
作者: faultfinder    時(shí)間: 2025-3-23 11:45
Alternative Methods and Their Application in Neurotoxicity Testing,potentially centrally-active and neurotoxic xenobiotics are continually entering the development ‘pipeline’ in industry. To identify neurotoxic chemicals and then legislate their use in society, previous and current emphasis is on the use of . methodology. The purpose of this review is to identify t
作者: Cardiac    時(shí)間: 2025-3-23 16:48
http://image.papertrans.cn/a/image/157703.jpg
作者: 搖曳    時(shí)間: 2025-3-23 19:26

作者: GOAT    時(shí)間: 2025-3-23 22:38

作者: 偽證    時(shí)間: 2025-3-24 05:10

作者: Herbivorous    時(shí)間: 2025-3-24 08:38

作者: LAST    時(shí)間: 2025-3-24 10:45

作者: A精確的    時(shí)間: 2025-3-24 18:22

作者: defile    時(shí)間: 2025-3-24 20:18

作者: Erythropoietin    時(shí)間: 2025-3-25 00:32

作者: 純樸    時(shí)間: 2025-3-25 04:38
Toxicity Data Derived from Man,Whilst man may be ‘the ultimate experimental animal’, there are very definite ethical limitations on the experiments to which he can be subjected (1). There is thus a need to consider the human toxicity data derived in real life from various surveillance schemes, as well as any advances in the study of human volunteers.
作者: defray    時(shí)間: 2025-3-25 10:54
Computer Modelling and Information Technology,The computer modelling of relationships between structure and biological response was considered by the FRAME Toxicity Committee in 1982 (1). This is an update of that first report.
作者: GROVE    時(shí)間: 2025-3-25 13:56

作者: 細(xì)胞學(xué)    時(shí)間: 2025-3-25 17:06
,Size (of Government) Doesn’t Matter,us prevent this disease with its vast social, human and economic costs (1). Whilst the disease has been recognised for many centuries, we are no nearer to making significant inroads into improving a patient’s prognosis for the majority of solid tumours, so cancer prevention should be a major goal.
作者: 心神不寧    時(shí)間: 2025-3-25 23:59

作者: Misgiving    時(shí)間: 2025-3-26 00:53
,Size (of Government) Doesn’t Matter,us prevent this disease with its vast social, human and economic costs (1). Whilst the disease has been recognised for many centuries, we are no nearer to making significant inroads into improving a patient’s prognosis for the majority of solid tumours, so cancer prevention should be a major goal.
作者: Adornment    時(shí)間: 2025-3-26 05:43

作者: Insulin    時(shí)間: 2025-3-26 08:34

作者: 我不重要    時(shí)間: 2025-3-26 15:03

作者: maculated    時(shí)間: 2025-3-26 20:44
Richard E. Baldwin,Aymo Brunettiests for mutagenicity (2, 3) and for biologically-active mineral dusts (4), it was difficult to find any collaborative interlaboratory attempts to establish the reliability and usefulness of . methods in toxicity testing (5). For this reason, FRAME established a research programme, which at that tim
作者: nullify    時(shí)間: 2025-3-26 20:58

作者: cortisol    時(shí)間: 2025-3-27 01:11
The Economic Impact of Container Traffic,s much satisfaction and pleasure as doing an experiment when you know you are doing it properly and you get an answer that you know is ‘clear cut’. I think it is reasonable for us to use the skills that we learn in the laboratory to try to do something about the safety of ourselves and our fellow ci
作者: 擔(dān)心    時(shí)間: 2025-3-27 09:21
https://doi.org/10.1007/978-1-349-12667-5allergy; neurotoxicity; pharmacology; research; toxicity; toxicology
作者: 光亮    時(shí)間: 2025-3-27 10:07
The Future for Acute Oral Toxicity Testing, indefensible that it must be replaced forthwith. But to the professional toxicologist, an acute toxicity test can give such valuable information on a new chemical, rapidly and with greater economy of animal usage than many other tests, that it is often regarded as one of the keystones of the profession.
作者: Minuet    時(shí)間: 2025-3-27 13:44
The Future of Alternative Approaches in Reproductive Toxicity Testing, research. Recommendations are listed at the end of each section, and a list of specific recommendations is included at the end of the report, which are directed at industry and the regulatory authorities for their consideration.
作者: 桉樹    時(shí)間: 2025-3-27 21:20
Ecotoxicology, Also, the term ‘harmful’ is open to interpretation, and ecotoxicologists are often concerned with the wide-ranging study of chemicals in eco-systems, including effects which may not be considered as adverse.
作者: embolus    時(shí)間: 2025-3-28 01:16

作者: 谷物    時(shí)間: 2025-3-28 04:22
Studies in Applied Regional Science research. Recommendations are listed at the end of each section, and a list of specific recommendations is included at the end of the report, which are directed at industry and the regulatory authorities for their consideration.
作者: 機(jī)械    時(shí)間: 2025-3-28 07:24
Benjamin H. Stevens,Glynnis A. Trainer Also, the term ‘harmful’ is open to interpretation, and ecotoxicologists are often concerned with the wide-ranging study of chemicals in eco-systems, including effects which may not be considered as adverse.
作者: 小爭(zhēng)吵    時(shí)間: 2025-3-28 11:48

作者: Biomarker    時(shí)間: 2025-3-28 16:43
non-animal alternatives. The book is a key document in the development, validation, and use of non-animal methods and is aimed at toxicologists, pharmacologists, and policy-makers in academia, industry and government.
作者: 驕傲    時(shí)間: 2025-3-28 21:40

作者: Ethics    時(shí)間: 2025-3-29 02:54
Concluding Remarks,unless there is some compelling reason for doing them. We ought not to use higher animals, and we ought not to use severe procedures unless, after careful consideration, we cannot see any way of avoiding it, because of some overriding need.
作者: noxious    時(shí)間: 2025-3-29 06:36

作者: charisma    時(shí)間: 2025-3-29 08:20
Textbook 1991Latest edition It covers developments in toxicology and the use of non-animal methods in toxicity testing since the first report, published in 1983; it highlights the need for rationalisation and harmonisation of regulatory guidelines for more critical attitudes toward currently accepted animal tests and for more
作者: Rotator-Cuff    時(shí)間: 2025-3-29 12:42
Richard E. Baldwin,Aymo Brunettitrial involving a relatively large number of coded chemicals (6). When other laboratories asked for access to coded chemicals, the FRAME Alternative Test Validation Scheme was established (7), and the results of a number of blind trials have since been published (e.g. 8–11).
作者: hypertension    時(shí)間: 2025-3-29 17:26
Hans Genberg,Arjan Kadareja,Umberto Schwarze main ways (2): in the selection of compounds during the development of new chemicals; in the prioritisation of existing chemicals being considered for toxicity evaluation; and in identifying chemicals with particular properties, so that . studies can be optimised.
作者: Minatory    時(shí)間: 2025-3-29 19:57
The Development, Validation and Acceptance of , Toxicity Tests,trial involving a relatively large number of coded chemicals (6). When other laboratories asked for access to coded chemicals, the FRAME Alternative Test Validation Scheme was established (7), and the results of a number of blind trials have since been published (e.g. 8–11).
作者: indemnify    時(shí)間: 2025-3-30 03:21
Future Developments in , Methodology,e main ways (2): in the selection of compounds during the development of new chemicals; in the prioritisation of existing chemicals being considered for toxicity evaluation; and in identifying chemicals with particular properties, so that . studies can be optimised.
作者: 松馳    時(shí)間: 2025-3-30 07:44
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作者: amyloid    時(shí)間: 2025-3-30 10:53
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作者: 字的誤用    時(shí)間: 2025-3-30 13:21
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作者: Morsel    時(shí)間: 2025-3-30 17:44
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作者: 高度表    時(shí)間: 2025-3-31 00:32
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作者: heart-murmur    時(shí)間: 2025-3-31 04:46
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