標(biāo)題: Titlebook: Aminopeptidases in Biology and Disease; Nigel M. Hooper,Uwe Lendeckel Book 2004 Springer Science+Business Media New York 2004 biology.neur [打印本頁] 作者: Callow 時(shí)間: 2025-3-21 17:09
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書目名稱Aminopeptidases in Biology and Disease讀者反饋學(xué)科排名
作者: 畏縮 時(shí)間: 2025-3-21 22:51
Effects on Mammals of the Aminopeptidase Inhibitor Bestatin,y important roles in the digestion and absorption of peptides in the brush border of the intestine and the kidney, in the metabolism of neuropeptides and leukotrienes, in the reproductive system and in the lens.作者: 潰爛 時(shí)間: 2025-3-22 04:07 作者: Host142 時(shí)間: 2025-3-22 06:46 作者: PLUMP 時(shí)間: 2025-3-22 10:08
,über Wahrscheinlichkeit — eine Topologie,tes is evident, the precise pathology of these conditions is unknown, making the identification of physiological substrates of ApPS and the development of specific ApPS inhibitors an attractive field of study.作者: GENRE 時(shí)間: 2025-3-22 16:44
,Vorschl?ge des Berichterstatters,selective inhibitors leads to a decrease in BP in hypertensive animals. Central APA may therefore be an interesting candidate target for the treatment of hypertension, which justifies the development of potent and selective APA inhibitors that cross the blood brain barrier as putative central antihypertensive agents.作者: Meander 時(shí)間: 2025-3-22 19:30 作者: 絕種 時(shí)間: 2025-3-22 22:33
Aminopeptidase Inhibitors as Anti-Hypertensive Drugs,selective inhibitors leads to a decrease in BP in hypertensive animals. Central APA may therefore be an interesting candidate target for the treatment of hypertension, which justifies the development of potent and selective APA inhibitors that cross the blood brain barrier as putative central antihypertensive agents.作者: incubus 時(shí)間: 2025-3-23 03:18
Book 2004tein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease..作者: Chagrin 時(shí)間: 2025-3-23 09:30 作者: INERT 時(shí)間: 2025-3-23 12:28 作者: 輕信 時(shí)間: 2025-3-23 14:41 作者: Militia 時(shí)間: 2025-3-23 21:31 作者: 規(guī)范要多 時(shí)間: 2025-3-23 22:48
,über Wahrscheinlichkeit — eine Topologie,pepetidase (P-LAP), which is also called cystine aminopeptidase, is the only membrane aminopeptidase known to open the N-terminal cystine loop of OT. The soluble form of P-LAP present in maternal serum is converted from the membrane-bound form in placenta by an enzyme with metalloprotease activity. 作者: 草本植物 時(shí)間: 2025-3-24 05:58 作者: AVOW 時(shí)間: 2025-3-24 07:54
,über Wahrscheinlichkeit — eine Topologie,y active derivatives of carbon-20 fatty acids, in particular arachidonic acid (AA). Leukotriene B. (LTB4) is one of the most potent chemoattractants known to date and is generated by the enzyme leukotriene A. hydrolase (LTA.H). The main physiological role of LTB4 is to recruit leukocytes to the site作者: 內(nèi)向者 時(shí)間: 2025-3-24 13:53
Zu einer Politik der Weltgesellschaft,tides. Purification of Ap-B from rat testes showed that this enzyme is a monomeric 72 kDa Zn.-dependent exopeptidase, which selectively removes Arg and/or Lys residues from the NH.-terminus of various peptides. ., Ap-B exhibits a weak ability to hydrolyze leukotriene A. into leukotriene B., a lipid 作者: 健壯 時(shí)間: 2025-3-24 16:14 作者: 煉油廠 時(shí)間: 2025-3-24 19:46
https://doi.org/10.1007/978-3-531-90914-1of target cells peptide fragments derived from foreign protein antigens bound to major histocompatibility complex (MHC) class I molecules. These peptides are generated in a process that involves at least two consecutive proteolytic steps and subcellular compartments. The first step, in which protein作者: crumble 時(shí)間: 2025-3-24 23:52 作者: 修剪過的樹籬 時(shí)間: 2025-3-25 07:22 作者: CUMB 時(shí)間: 2025-3-25 09:11
Virtuelle Mobilit?t‘ im ?Raum ohne Grenzen‘tack by other known aminopeptidases. Structurally, the enzyme is a member of the “pita-bread fold” family. It occurs in mammalian tissues in both cytosolic and glycosylphosphatidylinositol-anchored membrane-bound forms generated from two separate genes. The interest in the scientific community for t作者: aqueduct 時(shí)間: 2025-3-25 13:06 作者: Conduit 時(shí)間: 2025-3-25 18:14
Internationale ?akademische‘ Mobilit?ty sequenced genome of . predicts that there are ～19,000 genes, of which ～ 2% are proteases. The aminopeptidase family of . is relatively large and the use of RNAi and gene deletion mutants has shown that some family members have roles in embryogenesis, the germ line and growth. Expression pattern an作者: 欺騙手段 時(shí)間: 2025-3-25 20:27 作者: 天賦 時(shí)間: 2025-3-26 02:41 作者: 悶熱 時(shí)間: 2025-3-26 04:28
Hans-Jürgen Bieling,Tobias Haas,Julia LuxThe CD13/aminopeptidase N cell surface peptidase was originally identified as a marker for tumors of the hematopoietic system. Recent evidence however extends the role of CD13/APN to solid tumors as well where it is postulated to regulate angiogenesis and tumor metastasis.作者: 知道 時(shí)間: 2025-3-26 11:45 作者: 控制 時(shí)間: 2025-3-26 16:37
Methionine Aminopeptidase,ential modification. Indirect evidence suggests that removal of initiator Met by MetAP is important for the normal function of many proteins involved in DNA repair, signal transduction, cell transformation, secretory vesicle trafficking, and viral capsid assembly and infection. Currently, much effor作者: indecipherable 時(shí)間: 2025-3-26 18:02
Placental Leucine Aminopeptidase,-regulated membrane aminopeptidase (IRAP). P-LAP is translocated from the cytosol to the plasma membrane by oxytocin stimulation in vascular endothelial cells and by vasopressin in renal cells, which is similar to the finding that insulin stimulates IRAP translocation in adipocytes. P-LAP has a wide作者: 委屈 時(shí)間: 2025-3-26 23:15
Insulin-Regulated Aminopeptidase,ysiological role attributed to IRAP is the involvement of the enzyme in memory processing. AT. ligands, upon binding to the catalytic site of IRAP, enhance spatial learning, facilitate memory retention and retrieval and reverse amnesia. We postulate that the AT. ligands act via either one of these m作者: 頌揚(yáng)國家 時(shí)間: 2025-3-27 02:35 作者: 確認(rèn) 時(shí)間: 2025-3-27 07:57 作者: saphenous-vein 時(shí)間: 2025-3-27 10:57 作者: BRAWL 時(shí)間: 2025-3-27 16:35
ERAP1 and MHC Class I Antigen Presentation, is the first aminopeptidase found in the ER and appears to be one of the key factors affecting the repertoire of class I bound antigenic peptides on the cell surface. ERAP1 has broad substrate specificity and trims longer peptides to products of either nine or eight residues, which is the length pr作者: 果核 時(shí)間: 2025-3-27 18:00
Alanyl-Aminopeptidases in Human T Cells,lvement of APN and ApPS in the pathological immune response is evident, the precise molecular mechanisms remain to be identified. The development of inhibitors specific for APN and ApPS is an attractive field of study and would allow determination of the individual contribution of either enzyme in t作者: 附錄 時(shí)間: 2025-3-28 01:39 作者: Prostaglandins 時(shí)間: 2025-3-28 02:58
Nematode Aminopeptidases,ases are most probably conserved in animal and plant parasitic nematodes. Nevertheless, given the complexity of parasite life-cycles, parasitic nematode aminopeptidases are likely to have evolved novel biological roles, the best characterised to date being immunomodulation and immunoprotection. Thes作者: 提名的名單 時(shí)間: 2025-3-28 07:32 作者: Glaci冰 時(shí)間: 2025-3-28 13:19
,über Wahrscheinlichkeit — eine Topologie,-regulated membrane aminopeptidase (IRAP). P-LAP is translocated from the cytosol to the plasma membrane by oxytocin stimulation in vascular endothelial cells and by vasopressin in renal cells, which is similar to the finding that insulin stimulates IRAP translocation in adipocytes. P-LAP has a wide作者: 認(rèn)為 時(shí)間: 2025-3-28 18:25 作者: 輕快來事 時(shí)間: 2025-3-28 22:34
,über Wahrscheinlichkeit — eine Topologie,iscussion addressing the biochemical and catalytic properties of the enzyme will be given. The crystal structure of LTA.H was recently solved and special emphasis will therefore be placed on structural properties of the enzyme and the new findings emerging from the structural knowledge. In addition,作者: 初學(xué)者 時(shí)間: 2025-3-29 00:15
Zu einer Politik der Weltgesellschaft,e is bracketed by . and ., which encode a pre-protein translocase of the inner mitochondrial membrane and an ETS family transcription factor, respectively. The recent description of the mouse genome allows to localize the mouse Ap-B encoding gene on chromosome 1, in a putative inversed synthenic reg作者: 天真 時(shí)間: 2025-3-29 03:55 作者: deciduous 時(shí)間: 2025-3-29 11:03 作者: Ordeal 時(shí)間: 2025-3-29 12:41
https://doi.org/10.1007/978-94-015-0599-4lvement of APN and ApPS in the pathological immune response is evident, the precise molecular mechanisms remain to be identified. The development of inhibitors specific for APN and ApPS is an attractive field of study and would allow determination of the individual contribution of either enzyme in t作者: finale 時(shí)間: 2025-3-29 16:55
Virtuelle Mobilit?t‘ im ?Raum ohne Grenzen‘bitors, have also been studied. With this chapter we wish to overview the structural properties and expression, as well as biological functions of aminopeptidase P, and discuss its potential pathophysiological interest.作者: 偉大 時(shí)間: 2025-3-29 21:24 作者: Tinea-Capitis 時(shí)間: 2025-3-30 01:09
The Puromycin-Sensitive Aminopeptidase, in a variety of cellular functions. In addition to regulating the concentration of neuropeptides, ApPS has been suggested to be involved in reproductive function, cell cycle regulation, regulation of apoptosis, general protein turnover, and antigen presentation. Its involvement in these cellular fu作者: maverick 時(shí)間: 2025-3-30 06:30 作者: obtuse 時(shí)間: 2025-3-30 11:51
Placental Leucine Aminopeptidase,pepetidase (P-LAP), which is also called cystine aminopeptidase, is the only membrane aminopeptidase known to open the N-terminal cystine loop of OT. The soluble form of P-LAP present in maternal serum is converted from the membrane-bound form in placenta by an enzyme with metalloprotease activity. 作者: Conscientious 時(shí)間: 2025-3-30 15:57 作者: 過剩 時(shí)間: 2025-3-30 17:35 作者: CYT 時(shí)間: 2025-3-30 23:30
Arginyl Aminopeptidase,tides. Purification of Ap-B from rat testes showed that this enzyme is a monomeric 72 kDa Zn.-dependent exopeptidase, which selectively removes Arg and/or Lys residues from the NH.-terminus of various peptides. ., Ap-B exhibits a weak ability to hydrolyze leukotriene A. into leukotriene B., a lipid
