標題: Titlebook: Amine Oxidases and Their Impact on Neurobiology; Proceedings of the 4 Peter Riederer,Moussa B. H. Youdim Conference proceedings 1990 Spring [打印本頁] 作者: DUMMY 時間: 2025-3-21 18:22
書目名稱Amine Oxidases and Their Impact on Neurobiology影響因子(影響力)
書目名稱Amine Oxidases and Their Impact on Neurobiology影響因子(影響力)學科排名
書目名稱Amine Oxidases and Their Impact on Neurobiology網絡公開度
書目名稱Amine Oxidases and Their Impact on Neurobiology網絡公開度學科排名
書目名稱Amine Oxidases and Their Impact on Neurobiology被引頻次
書目名稱Amine Oxidases and Their Impact on Neurobiology被引頻次學科排名
書目名稱Amine Oxidases and Their Impact on Neurobiology年度引用
書目名稱Amine Oxidases and Their Impact on Neurobiology年度引用學科排名
書目名稱Amine Oxidases and Their Impact on Neurobiology讀者反饋
書目名稱Amine Oxidases and Their Impact on Neurobiology讀者反饋學科排名
作者: Foolproof 時間: 2025-3-21 22:05 作者: Parley 時間: 2025-3-22 04:21
Problemstellung und Zielsetzungne deprenyl binding. A high dose of unlabelled deprenyl was then administered to inhibit the enzyme and tracer doses of . C-L-deprenyl, with subsequent PET analyses, were given at 0, 2, 7, 21 and 42 days. The half-life for the turnover rate calculated was found to be 6.5 days.作者: BALK 時間: 2025-3-22 08:24 作者: 四目在模仿 時間: 2025-3-22 10:25
https://doi.org/10.1007/978-3-658-34957-8and time-dependence of the inhibiton were also established in each case. The kinetic parameters defining non-covalent complex formation and covalent adduct formation were calculated for the mechanism-based inhibition of both MAO-A and MAO-B by these compounds.作者: glucagon 時間: 2025-3-22 16:51
https://doi.org/10.1007/978-3-476-03712-1 B type of MAO was found. Influence of substrate structure on its biotransformation effectiveness is realized by the principle — “better binding-worse catalysis”. MAO inactivation during the reaction is appeared to be realized as result of product inhibition and perhaps of substrate inhibition.作者: Connotation 時間: 2025-3-22 17:27 作者: 肥料 時間: 2025-3-22 22:23
Molecular neuroanatomy of MAO-A and MAO-Bs in human post-mortem brain. Furthermore, using in situ hybridization histochemistry, locus coeruleus and raphé neurons in the human brain were found to code for MAO-A and MAO-B respectively and not vice versa.作者: 避開 時間: 2025-3-23 02:03 作者: 來自于 時間: 2025-3-23 06:02
Effect of selective and reversible MAO inhibitors on dopamine outflow in rat striatum: a microdialysnd homovanillic acid (HVA) was studied in the rat by transstriatal microdialysis. Reversible MAO-A inhibitors markedly increased the output of DA and concomitantly decreased the output of DOPAC and HVA. These effects were absent with the highly selective MAO-B inhibitor Ro 19-6327.作者: Outmoded 時間: 2025-3-23 13:24 作者: inflate 時間: 2025-3-23 15:49
Stylbasole analogues of MPTP as monoamine oxidase (MAO) substrates B type of MAO was found. Influence of substrate structure on its biotransformation effectiveness is realized by the principle — “better binding-worse catalysis”. MAO inactivation during the reaction is appeared to be realized as result of product inhibition and perhaps of substrate inhibition.作者: 胰島素 時間: 2025-3-23 18:12
https://doi.org/10.1007/978-3-662-67441-3.g. white matter. When the brains from the controls were compared with those with AD, the mean values for .H-deprenyl binding was higher in the latter group, however, more generalised than previously reported.作者: Galactogogue 時間: 2025-3-23 23:02
https://doi.org/10.1007/978-3-531-94092-2unds can be used as VPA prodrugs. Both compounds, however, at relatively low doses exhibited distinct tremor effects in mice and rats. They also potentiate the convulsant effect induced by mercaptopropionic acid (MPA).作者: 智力高 時間: 2025-3-24 05:26
https://doi.org/10.1007/978-3-476-03712-1 analogues in which this position is blocked with a substituent. In preliminary acute studies at a dose of 0.1 mmol/kg .-chloro-PLZ was found to have a similar effect to PLZ on the inhibition of MAO and to lead to an elevation of catecholamines and 5-hydroxytryptamine (5-HT) in rat whole brain.作者: Malaise 時間: 2025-3-24 07:13
Handels-, Wechsel- und Scheckrecht,support the hypothesis of a glycine-mediated anticonvulsant activity for milacemide and suggest that the increased formation of UK. to the detriment of glycinamide might account for the lack of protection against bicuculline-induced lethality by milacemide in rats.作者: intention 時間: 2025-3-24 13:25 作者: vertebrate 時間: 2025-3-24 15:12
MAO activity, metabolism and anticonvulsant activity of milacemide in rats and micesupport the hypothesis of a glycine-mediated anticonvulsant activity for milacemide and suggest that the increased formation of UK. to the detriment of glycinamide might account for the lack of protection against bicuculline-induced lethality by milacemide in rats.作者: 水槽 時間: 2025-3-24 22:28 作者: LARK 時間: 2025-3-25 01:55 作者: Chandelier 時間: 2025-3-25 04:25
The interaction of transport mechanisms and intracellular enzymes in metabolizing systemsivity of these intracellular enzymes, it is unlikely that either COMT or MAO is ever saturated in vivo. However, in vitro saturation of extraneuronal COMT and MAO reveals that extraneuronal COMT is a high-affinity, but extraneuronal MAO a low-affinity enzyme. Hence, membrane-bound COMT appears to be作者: Alcove 時間: 2025-3-25 08:41
The mechanism of action of antidepressants revisedmore selective antidepressants led to new reflections upon the mechanism of action. On the level of transmitters, α.upregulation, increased activity of the dopaminergic system, an alteration in the balance between the different transmitter systems, are reported and seem to be important. Most promisi作者: 有偏見 時間: 2025-3-25 13:14 作者: noxious 時間: 2025-3-25 15:48
,Die rechtliche Identit?t Gesamttirols,ivity of these intracellular enzymes, it is unlikely that either COMT or MAO is ever saturated in vivo. However, in vitro saturation of extraneuronal COMT and MAO reveals that extraneuronal COMT is a high-affinity, but extraneuronal MAO a low-affinity enzyme. Hence, membrane-bound COMT appears to be作者: 發(fā)現(xiàn) 時間: 2025-3-25 23:44 作者: gain631 時間: 2025-3-26 01:56
https://doi.org/10.1007/978-3-658-34957-8/day, both analogues produced greater inhibition of MAO-A and -B than did tranylcypromine. 4-Methoxytranylcypromine and 4-fluorotranylcypromine were similar in their extent of inhibition of MAO-B but the former was more potent than the latter at inhibition MAO-A.作者: chronicle 時間: 2025-3-26 06:55 作者: Mast-Cell 時間: 2025-3-26 09:20 作者: 王得到 時間: 2025-3-26 15:35 作者: Grating 時間: 2025-3-26 18:25
The expression of human MAO-A and B genes and adult brains. The tissue distribution of these transcripts was determined. Small intestine and placenta express, in addition to the MAO-A 5Kb transcript, a 2Kb transcript determined to lack a 3′ flanking region. MAO-A appeared prior to MAO-B in the fetal brain, whereas both MAO-A and B were fou作者: diabetes 時間: 2025-3-26 23:19
Molecular neuroanatomy of MAO-A and MAO-Band abundance of MAO-A and MAO-B in the central nervous system and peripheral organs in the rat. The in vitro approach was also used to map the enzymes in human post-mortem brain. Furthermore, using in situ hybridization histochemistry, locus coeruleus and raphé neurons in the human brain were found作者: 健談 時間: 2025-3-27 04:47
Turnover of monoamine oxidase B (MAO-B) in pig brain by positron emission tomography using 11C-L-depirreversible ligand, which bind stoichiometrically to the enzyme. A tracer dose of. C-L-deprenyl was injected and PET scans performed to obtain baseline deprenyl binding. A high dose of unlabelled deprenyl was then administered to inhibit the enzyme and tracer doses of . C-L-deprenyl, with subsequen作者: 小木槌 時間: 2025-3-27 08:42 作者: 雀斑 時間: 2025-3-27 12:26 作者: 我沒有命令 時間: 2025-3-27 14:29
Some pharmacological implications of MAO-mediated deamination of branched aliphatic amines: 2-Propylbazide-sensitive amine oxidase. The deaminated product, valproic acid (VPA), was identified by HPLC-fluorometric assessment. Absorption and biotransformation of these compounds and their VPA metabolite into the brain were rapid processes. An investigation was conducted to examine whether these compo作者: Astigmatism 時間: 2025-3-27 21:29 作者: 逃避現(xiàn)實 時間: 2025-3-28 00:23 作者: onlooker 時間: 2025-3-28 05:22
Ring-substituted analogues of tranylcypromine as monoamine oxidase inhibitorstested for their ability to inhibit, relative to tranylcypromine, monoamine oxidase (MAO) -A and -B in rat brain after administration of low doses (1.2 and 3.7 μmol/kg) of the drugs. One hour after intraperitoneal injection of the lower dose, tranylcypromine was weaker than 4-fluorotranylcypromine a作者: Dorsal-Kyphosis 時間: 2025-3-28 09:02 作者: meditation 時間: 2025-3-28 10:43
Stylbasole analogues of MPTP as monoamine oxidase (MAO) substrates compounds was shown to be catalyzed by both serotonine specifical and benzylamine specifical MAO activities. Markedly high affinity of stylbasoles to B type of MAO was found. Influence of substrate structure on its biotransformation effectiveness is realized by the principle — “better binding-worse作者: 火花 時間: 2025-3-28 17:24
MAO activity, metabolism and anticonvulsant activity of milacemide in rats and micesuggested that the anticonvulsant activity of milacemide might be related to MAO-B- mediated glycine formation, brain and liver MAO-A and-B activities and the urinary metabolic pattern of milacemide were determined in the same mice and rat strains. Similar brain and liver MAO activities were found i作者: Malfunction 時間: 2025-3-28 18:48
Amine Oxidases and Their Impact on Neurobiology978-3-7091-9113-2Series ISSN 0303-6995 作者: 不成比例 時間: 2025-3-29 02:40
0303-6995 Overview: 978-3-211-82239-5978-3-7091-9113-2Series ISSN 0303-6995 作者: 鴿子 時間: 2025-3-29 05:36 作者: 最低點 時間: 2025-3-29 09:41 作者: 做作 時間: 2025-3-29 15:12 作者: 亞當心理陰影 時間: 2025-3-29 19:13
[3H] Harman labels selectively and with high affinity the active site of monoamine oxidase (EC 1.4.3f the CNS of the 3 species [.H]harman binding exhibits the same pharmacological profile in displacement studies. A detailed analysis reveals a high specificity for MAO-A..Furthermore, we applied [.H]harman binding to quantify the MAO-A content in 6 CNS regions of each species as well as in 6 visceral organs of the rat.作者: dapper 時間: 2025-3-29 20:11
https://doi.org/10.1007/978-3-662-67441-3Immunofluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of MAO-A and MAO-B revealed that only about 10% of the melanin-containing neurons are positive for MAO-A, while they are substantially free of MAO-B.作者: 慢慢流出 時間: 2025-3-30 03:09
Problemstellung und ZielsetzungIn vivo voltammetric analyses on the action of the monoamine oxidase inhibitors pargyline, deprenyl, and clorgyline on dopamine and serotonin metabolism in rat brain showed strain and regional differences depending on the compound under study.作者: 丑惡 時間: 2025-3-30 06:31
Immuno-fluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of Immunofluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of MAO-A and MAO-B revealed that only about 10% of the melanin-containing neurons are positive for MAO-A, while they are substantially free of MAO-B.作者: 虛弱 時間: 2025-3-30 08:13
In vivo studies on the effect of monoamine oxidase inhibitors on dopamine and serotonin metabolism iIn vivo voltammetric analyses on the action of the monoamine oxidase inhibitors pargyline, deprenyl, and clorgyline on dopamine and serotonin metabolism in rat brain showed strain and regional differences depending on the compound under study.作者: 同時發(fā)生 時間: 2025-3-30 15:50 作者: 無底 時間: 2025-3-30 19:20
,Die Identit?t Tirols in der EU,nimals and in humans. Lack of absolute specificity of enzymes, storage mechanisms and transporters allows .C-or .F-labelled “false transmitters” to be formed, stored and released from nerve terminals. Discussed are the assumptions, limitations, and advantages of .F-6-fluoroDOPA, .F-6-fluorodopamine,作者: 確定方向 時間: 2025-3-31 00:02
https://doi.org/10.1007/978-3-211-73754-5n the mechanism of action of antidepressants. Due to these investigations, until recently an enhanced activity of the central noradrenergic and/or serotonergic transmitter system was considered essential for the clinical antidepressive action. Such enhancement could be achieved either presynapticall作者: 出來 時間: 2025-3-31 00:55 作者: PHIL 時間: 2025-3-31 05:27 作者: 令人發(fā)膩 時間: 2025-3-31 10:49
Problemstellung und Zielsetzungirreversible ligand, which bind stoichiometrically to the enzyme. A tracer dose of. C-L-deprenyl was injected and PET scans performed to obtain baseline deprenyl binding. A high dose of unlabelled deprenyl was then administered to inhibit the enzyme and tracer doses of . C-L-deprenyl, with subsequen作者: Soliloquy 時間: 2025-3-31 17:23
https://doi.org/10.1007/978-3-662-67441-3nd 3 brains from patients with Alzheimer’s disease (AD). High .H-L-deprenyl binding was found in e.g. basal ganglia, cingulate gyrus, and insula cortex. Temporal cortex, parietal cortex, occipital cortex and various nuclei of the thalamus, showed moderate density, while low binding was observed in e作者: Ruptured-Disk 時間: 2025-3-31 19:57
