標(biāo)題: Titlebook: Alzheimer’s Disease: Lessons from Cell Biology; K. S. Kosik (Associate Professor of Neurology and Conference proceedings 1995 Springer-Ve [打印本頁(yè)] 作者: 自治 時(shí)間: 2025-3-21 19:38
書(shū)目名稱(chēng)Alzheimer’s Disease: Lessons from Cell Biology影響因子(影響力)
書(shū)目名稱(chēng)Alzheimer’s Disease: Lessons from Cell Biology影響因子(影響力)學(xué)科排名
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書(shū)目名稱(chēng)Alzheimer’s Disease: Lessons from Cell Biology被引頻次
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書(shū)目名稱(chēng)Alzheimer’s Disease: Lessons from Cell Biology讀者反饋
書(shū)目名稱(chēng)Alzheimer’s Disease: Lessons from Cell Biology讀者反饋學(xué)科排名
作者: 織物 時(shí)間: 2025-3-21 23:21
,Mechanisms of Molecular Sorting in Polarized Cells: Relevance to Alzheimer’s Disease, that the targeting of newly synthesized membrane proteins is governed largely by a ubiquitously distributed set of cytoplasmic domain sorting signals. These determinants may be superficially related to well-characterized signals for localization at plasma membrane-coated pits. Their inactivation re作者: 表主動(dòng) 時(shí)間: 2025-3-22 01:51 作者: 使高興 時(shí)間: 2025-3-22 08:36
,Alzheimer’s Disease and Hemorrhagic Stroke: Their Relationship to ,A4 Amyloid Deposition,protein (APP) located at chromosome 21q21.2. Mutations in APP have also been found in families segregating hemorrhagic stroke due to congophilic .A4 amyloid angiopathy (CAA) both in the presence and absence of AD. These mutations are located close to known proteolytic cleavage sites in APP, either a作者: 加強(qiáng)防衛(wèi) 時(shí)間: 2025-3-22 09:51
Combining In Vitro Cell Biology and In Vivo Mouse Modelling to Study the Mechanisms Underlying Alzhngles and cerebrovascular deposits. Neither the molecular mechanisms of the formation of these structures nor their direct bearing on the neurodegeneration per se are understood. The major component of the senile plaques and vascular deposits is the .-amyloid peptide (.A4), a 39–43 amino acid fragme作者: 帶傷害 時(shí)間: 2025-3-22 15:54 作者: 泄露 時(shí)間: 2025-3-22 17:28 作者: 船員 時(shí)間: 2025-3-22 23:08
Regulation and Structure of the MAP Kinases ERK1 and ERK2,s, growth factor-stimulated protein kinases that phosphorylate and thereby modulate the properties of many proteins that have key regulatory functions. These include other protein kinases, transcription factors, membrane enzymes, and cytoskeletal proteins (e.g., tau, MAP2). This wide array of phosph作者: Deference 時(shí)間: 2025-3-23 03:56
Calcineurin as a Pivotal Ca2+-Sensitive Switching Element in Biological Responses: Implications formically . to changes in cellular response. A hallmark feature of Alzheimer’s disease is the presence of “hyperphosphorylated” forms of the microtubule-associated protein, tau, in paired helical filaments. Although the relationship of this biochemical abnormality to disease etiology and pathology is 作者: 相一致 時(shí)間: 2025-3-23 08:25 作者: Limousine 時(shí)間: 2025-3-23 10:48 作者: Virtues 時(shí)間: 2025-3-23 16:43 作者: Mystic 時(shí)間: 2025-3-23 19:56
Modifications of Phosphorylated Tau Immunoreactivity Linked to Excitotoxicity in Neuronal Cultures,vivo neuronal degradation and death (Meldrum and Garthwaite 1991). Three types of post-synaptic receptors are described: N-Methyl D aspartate, AMPA/Kainate, and metabotropic according to their principal pharmacological agonists. A large variety of molecules can activate these three post-synaptic rec作者: 不愛(ài)防注射 時(shí)間: 2025-3-24 01:03 作者: Peculate 時(shí)間: 2025-3-24 02:44 作者: 昆蟲(chóng) 時(shí)間: 2025-3-24 09:52 作者: regale 時(shí)間: 2025-3-24 14:24 作者: Chauvinistic 時(shí)間: 2025-3-24 16:30 作者: 強(qiáng)制性 時(shí)間: 2025-3-24 22:05
https://doi.org/10.1007/978-3-662-34627-3fic protein is required for the endocytosis of VAMP since it is endocytosed rapidly in transfected CHO cells. Mutational analysis of VAMP showed that the signal for endocytosis was constrained to a small sequence which showed no homologies with other known endocytotic signals. Domains required for s作者: 首創(chuàng)精神 時(shí)間: 2025-3-24 23:39 作者: 易怒 時(shí)間: 2025-3-25 04:51 作者: Cholagogue 時(shí)間: 2025-3-25 10:55
https://doi.org/10.1007/978-3-531-90487-0generated at least in part from .APP molecules that traffic asymmetrically to the cell surfaces, with the major portion of A. being released from the basolateral surface. These and other studies of the detailed cellular mechanism for generation of A. should provide insights into specifically inhibit作者: Irascible 時(shí)間: 2025-3-25 13:50 作者: 離開(kāi) 時(shí)間: 2025-3-25 19:11
https://doi.org/10.1007/978-3-531-90487-0is extraphosphorylation may provide PHF-tau with its unusual properties, including assembly incompetence..The other major modification of PHF is ubiquitination. From analysis of the PHF smear that presumably represents more modified PHF, the ubiquitin-targeted protein was identified as tau and the c作者: 不愿 時(shí)間: 2025-3-25 21:33 作者: 取之不竭 時(shí)間: 2025-3-26 00:33
https://doi.org/10.1007/978-3-531-90487-0from the deepest cortical layers where neurons are onto-genetically the oldest. This phosphorylated tau was found in axons and dendrites of cortical neurons at all developmental stages, whereas unphosphorylated tau tended to disappear from dendrites during development. The timing of appearance of ph作者: cliche 時(shí)間: 2025-3-26 04:56 作者: dagger 時(shí)間: 2025-3-26 10:27 作者: Bricklayer 時(shí)間: 2025-3-26 15:19
https://doi.org/10.1007/978-3-658-21867-6eir differentiation in the cerebellum and hindbrain..In considering possible causes for cell loss in . mice, I speculated that gross perturbations in signal transduction within terminally differentiated neurons can cause reactivation of programmed cell death (Heintz 1993). This process is formally a作者: chondromalacia 時(shí)間: 2025-3-26 16:58 作者: MEET 時(shí)間: 2025-3-26 23:02
https://doi.org/10.1007/978-3-658-21031-1se amyloid, can be unremarkable, and neurofibrillary tangles often occur at sites anatomically distant from plaques..We have found that a secreted fragment of APP can stimulate the mitogen-activated protein kinase (MAPK) in a ras-dependent manner and that stimulation along this pathway results in th作者: indenture 時(shí)間: 2025-3-27 03:16 作者: 閃光你我 時(shí)間: 2025-3-27 08:14
K. S. Kosik (Associate Professor of Neurology and 作者: impale 時(shí)間: 2025-3-27 12:19
0945-6066 e disease in 1907, the science of Alzheimer‘s disease was descriptive, and lay in the province of pathologists. This time period, during which a great deal was 978-3-642-79425-4978-3-642-79423-0Series ISSN 0945-6066 Series E-ISSN 2196-310X 作者: Graphite 時(shí)間: 2025-3-27 13:55 作者: Cardioversion 時(shí)間: 2025-3-27 21:46 作者: 巫婆 時(shí)間: 2025-3-28 01:20
Regulation of Receptor Trafficking by ras-Like GTPases,ional transport vesicles in cells expressing rab9 S21N protein. This is a surprise, since rab proteins are believed to facilitate transport vesicle targeting and/or fusion. Our findings suggest that transport vesicle formation is regulated by the availability of transport factors assembled in some f作者: 躲債 時(shí)間: 2025-3-28 06:10 作者: 我不死扛 時(shí)間: 2025-3-28 09:43 作者: 小步走路 時(shí)間: 2025-3-28 13:13 作者: 值得贊賞 時(shí)間: 2025-3-28 16:39 作者: conspicuous 時(shí)間: 2025-3-28 18:57
A Phosphorylated Tau Species Is Transiently Present in Developing Cortical Neurons and Is Not Assocfrom the deepest cortical layers where neurons are onto-genetically the oldest. This phosphorylated tau was found in axons and dendrites of cortical neurons at all developmental stages, whereas unphosphorylated tau tended to disappear from dendrites during development. The timing of appearance of ph作者: 大廳 時(shí)間: 2025-3-29 00:25
Modifications of Phosphorylated Tau Immunoreactivity Linked to Excitotoxicity in Neuronal Cultures,l 1991; Mattson et al. 1992). Glutamate is also able to produce an intracellular signal transduction into neurons leading to protein phosphorylations (Scholz and Palfrey 1991). Tau is a microtubule-associated protein which favours microtubule polymerisation and stabilisation (Kosik 1993). One of the作者: considerable 時(shí)間: 2025-3-29 04:16
Neurofilaments and Motor Neuron Disease,tion and severe skeletal muscle atrophy. These data indicate that excessive accumulation of neurofilaments can trigger selective motor neuron failure. Since such accumulation is seen both in sporadic and familial ALS, it is almost certain to be a key intermediate in the pathway of pathogenesis leadi作者: Analogy 時(shí)間: 2025-3-29 10:32 作者: 無(wú)孔 時(shí)間: 2025-3-29 12:16
Amyloid ,-Peptide Induces Necrotic Cell Death in PC12 Cells,t of oxidative stress (Behl et al. 1992), although the two may be linked. The cytotoxicity of A.P 1–40 has been associated with a fragment including residues 25–35 (Yankner et al. 1990). This study aimed at determining the mechanism of this .25–35 induced cytotoxicity and distinguishing between eith作者: 暫時(shí)休息 時(shí)間: 2025-3-29 16:55
,Linking Amyloid Precursor Protein Processing and Tau-Related Pathology in Alzheimer’s Disease,se amyloid, can be unremarkable, and neurofibrillary tangles often occur at sites anatomically distant from plaques..We have found that a secreted fragment of APP can stimulate the mitogen-activated protein kinase (MAPK) in a ras-dependent manner and that stimulation along this pathway results in th作者: 金哥占卜者 時(shí)間: 2025-3-29 21:15 作者: HALO 時(shí)間: 2025-3-30 00:02
Research and Perspectives in Alzheimer‘s Diseasehttp://image.papertrans.cn/a/image/154273.jpg作者: 本土 時(shí)間: 2025-3-30 06:50
Alzheimer’s Disease: Lessons from Cell Biology978-3-642-79423-0Series ISSN 0945-6066 Series E-ISSN 2196-310X 作者: 脫離 時(shí)間: 2025-3-30 08:29 作者: Charade 時(shí)間: 2025-3-30 14:41 作者: frozen-shoulder 時(shí)間: 2025-3-30 17:36 作者: 看法等 時(shí)間: 2025-3-30 22:48
https://doi.org/10.1007/978-3-662-34627-3 that the targeting of newly synthesized membrane proteins is governed largely by a ubiquitously distributed set of cytoplasmic domain sorting signals. These determinants may be superficially related to well-characterized signals for localization at plasma membrane-coated pits. Their inactivation re作者: Adj異類(lèi)的 時(shí)間: 2025-3-31 02:56 作者: 有說(shuō)服力 時(shí)間: 2025-3-31 07:59
https://doi.org/10.1007/978-3-662-34626-6protein (APP) located at chromosome 21q21.2. Mutations in APP have also been found in families segregating hemorrhagic stroke due to congophilic .A4 amyloid angiopathy (CAA) both in the presence and absence of AD. These mutations are located close to known proteolytic cleavage sites in APP, either a作者: 可以任性 時(shí)間: 2025-3-31 12:34 作者: Meager 時(shí)間: 2025-3-31 14:23
https://doi.org/10.1007/978-3-531-90487-0larger transmembrane glycoprotein which can be subject to several cleavage events and secreted. The predominant processing pathway cleaves APP within the .A4 peptide sequence, while other events can result in minor quantities of .A4. Thus it is believed that the accumulation of .A4 results from one 作者: Cholagogue 時(shí)間: 2025-3-31 21:25 作者: instill 時(shí)間: 2025-3-31 21:54
https://doi.org/10.1007/978-3-531-90487-0s, growth factor-stimulated protein kinases that phosphorylate and thereby modulate the properties of many proteins that have key regulatory functions. These include other protein kinases, transcription factors, membrane enzymes, and cytoskeletal proteins (e.g., tau, MAP2). This wide array of phosph作者: cinder 時(shí)間: 2025-4-1 02:19 作者: COMMA 時(shí)間: 2025-4-1 07:20 作者: Unsaturated-Fat 時(shí)間: 2025-4-1 13:54
https://doi.org/10.1007/978-3-531-90487-0y found in Alzheimer’s disease (AD), amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC), dementia pugilistica, head injury, Hallervorden-Spatz disease, post-encephalitic parkinsonism, and progressive supranuclear palsy (PSP) and are frequently observed in Pick’s disease (H作者: 饒舌的人 時(shí)間: 2025-4-1 16:30 作者: 嚴(yán)峻考驗(yàn) 時(shí)間: 2025-4-1 18:31
