標(biāo)題: Titlebook: Alzheimer’s Disease; Methods and Protocol Jerold Chun Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive license to [打印本頁] 作者: 年邁 時間: 2025-3-21 17:05
書目名稱Alzheimer’s Disease影響因子(影響力)
書目名稱Alzheimer’s Disease影響因子(影響力)學(xué)科排名
書目名稱Alzheimer’s Disease網(wǎng)絡(luò)公開度
書目名稱Alzheimer’s Disease網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Alzheimer’s Disease被引頻次
書目名稱Alzheimer’s Disease被引頻次學(xué)科排名
書目名稱Alzheimer’s Disease年度引用
書目名稱Alzheimer’s Disease年度引用學(xué)科排名
書目名稱Alzheimer’s Disease讀者反饋
書目名稱Alzheimer’s Disease讀者反饋學(xué)科排名
作者: deadlock 時間: 2025-3-21 20:24 作者: 星星 時間: 2025-3-22 00:34
FISHing for Chromosome Instability and Aneuploidy in the Alzheimer’s Disease Braining the brain. Although the types and rates of chromosome instability in the AD brain remain a matter of debate, molecular cytogenetic analysis of brain cells appears to be important for uncovering mechanisms of neurodegeneration. Here, we describe a FISH protocol for studying chromosome instability and aneuploidy in the AD brain.作者: 公理 時間: 2025-3-22 07:43 作者: Ascribe 時間: 2025-3-22 09:28 作者: 字謎游戲 時間: 2025-3-22 14:59
Edgar R??ger,Klaus Haucke,Erbard Jadend vasculature, enables sensitive detection of focal BBB vascular abnormalities, and reveals the spatial distribution of Aβ plaques and fibrin deposits, in large tissue volumes from cleared human brains. Overall, fibrinogen iDISCO enables the investigation of neurovascular and neuroimmune mechanisms driving neurodegeneration in disease.作者: licence 時間: 2025-3-22 18:50 作者: 沒有貧窮 時間: 2025-3-23 01:16
Extraction and Purification of Single Nuclei from Frozen Human Brain Tissuecells, processes, and synapses—which precludes intact and selective isolation of single brain cells. Here, we describe a protocol for the extraction and purification of intact single nuclei from frozen human brain tissue along with modifications to accommodate numerous downstream analyses, particularly for transcriptomic applications.作者: 卷發(fā) 時間: 2025-3-23 02:48
Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electar membranes in human postmortem brain samples, as well as the steps necessary to acquire scanning electron microscopy (SEM) images of microglial cell bodies. In the last section, we cover the quantitative analysis of various microglial cytoplasmic organelles and their interactions with other parenchymal elements.作者: chlorosis 時間: 2025-3-23 08:01
Three-Dimensional Imaging of Fibrinogen and Neurovascular Alterations in Alzheimer’s Diseased vasculature, enables sensitive detection of focal BBB vascular abnormalities, and reveals the spatial distribution of Aβ plaques and fibrin deposits, in large tissue volumes from cleared human brains. Overall, fibrinogen iDISCO enables the investigation of neurovascular and neuroimmune mechanisms driving neurodegeneration in disease.作者: 無目標(biāo) 時間: 2025-3-23 10:31
Modeling Alzheimer’s Disease Using Human Brain Organoidsculture. Here, we describe the protocol for the generation of brain organoids derived from AD patients and for the analysis of AD-derived pathology. AD organoids can recapitulate beta-amyloid and tau pathological features, making them a promising model for studying the molecular mechanisms underlying disease and for in vitro drug testing.作者: 無法解釋 時間: 2025-3-23 17:15 作者: fatty-acids 時間: 2025-3-23 20:43
https://doi.org/10.1007/978-3-662-01470-7o the analysis of Alzheimer’s disease (AD). We provide a detailed protocol for applying iMAT to create models of personalized metabolic networks, which can be further processed to identify reactions associated with abnormal metabolism.作者: integrated 時間: 2025-3-23 23:58 作者: GLIB 時間: 2025-3-24 03:40 作者: Mnemonics 時間: 2025-3-24 08:41
1064-3745 ation advice from the expertsThis volume explores the latest techniques used to study the human brain towards understanding Alzheimer’s Disease and related neurodegenerative disorders. Contributed to by world-renowned experts, the chapters in this book are divided into five parts. Part One discusses作者: surmount 時間: 2025-3-24 12:14
https://doi.org/10.1007/978-3-663-06775-7l cells provides the opportunity to investigate multiple cell types originating from the same donor. This represents a novel approach for . research, with the potential for discovering the shared or distinct molecular features among the glia and vascular cells from the same individual.作者: 組成 時間: 2025-3-24 16:33
Isolation of Human Microglia from Neuropathologically Diagnosed Cases in the Single-Cell Eral cells provides the opportunity to investigate multiple cell types originating from the same donor. This represents a novel approach for . research, with the potential for discovering the shared or distinct molecular features among the glia and vascular cells from the same individual.作者: Overthrow 時間: 2025-3-24 21:58
Book 2023ials and reagents, step-by-step, readily reproducible laboratory protocols, andtips on troubleshooting and avoiding known pitfalls..Cutting-edge and thorough, .Alzheimer’s Disease: Methods and Protocols. is a valuable tool for all researchers who want to expand their knowledge and understanding of t作者: 整理 時間: 2025-3-25 01:27
https://doi.org/10.1007/978-3-663-20308-7advanced technologies demand improved methodologies for the procurement, characterization, stabilization, and preparation of both normal and diseased human brain tissues. Here, we describe our current protocols for the procurement and characterization of fixed brain tissue, to enable systematic and 作者: V切開 時間: 2025-3-25 04:12
https://doi.org/10.1007/978-3-322-98858-4es. Culturing human primary cortical astrocyte (pHA)- or induced pluripotent stem cell (iPSC)-derived human neural stem cells in this biohybrid hydrogel system has led to the discovery of novel regulatory pathways underlying neurodegenerative pathology in different phases of AD.作者: 散開 時間: 2025-3-25 08:50 作者: 責(zé)難 時間: 2025-3-25 12:17
,Implizites Wissen und Innovationsproze?,e harmonization of results across independent studies. In this chapter, we contextualize these issues with recent reports identifying correlations between brain lipids and neurological diseases, and we describe the workflow our group has optimized for analysis of the blood plasma sphingolipidome, ad作者: 人工制品 時間: 2025-3-25 18:13
,Implizites Wissen und Innovationsproze?, spectrometer to scan brain tissue slices with high spatial resolution, analyzing 50 μm cell layers. The lipid spectra obtained for each pixel are transformed to color-coded intensity maps of hundreds of lipid species included those within a single tissue slice.作者: modish 時間: 2025-3-25 21:01 作者: 陰郁 時間: 2025-3-26 04:11 作者: irreparable 時間: 2025-3-26 06:28 作者: 尋找 時間: 2025-3-26 09:31 作者: Custodian 時間: 2025-3-26 14:55 作者: 同時發(fā)生 時間: 2025-3-26 18:27
Mass Spectrometry for the Advancement of Lipid Analysis in Alzheimer’s Research spectrometer to scan brain tissue slices with high spatial resolution, analyzing 50 μm cell layers. The lipid spectra obtained for each pixel are transformed to color-coded intensity maps of hundreds of lipid species included those within a single tissue slice.作者: 吞吞吐吐 時間: 2025-3-26 22:14 作者: 有角 時間: 2025-3-27 05:00 作者: 遣返回國 時間: 2025-3-27 05:58
Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neurocing techniques, it has become possible to use human brain tissue to study, in great detail, the structural, molecular, and even functional underpinnings of human brain disease. In the century following the first description of Alzheimer’s disease (AD), numerous technological advances applied to hum作者: Thyroxine 時間: 2025-3-27 11:50 作者: Retrieval 時間: 2025-3-27 16:48 作者: indenture 時間: 2025-3-27 18:54
Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electd procedure is provided to improve the ultrastructural quality of the samples, using aldehyde fixatives followed by immunoperoxidase staining of allograft inflammatory factor 1 (AIF1, also known as IBA1), a marker of myeloid cells, and cluster of differentiation . (CD68), a marker of phagolysosomal 作者: Neonatal 時間: 2025-3-27 23:44 作者: Aura231 時間: 2025-3-28 06:04 作者: 嘮叨 時間: 2025-3-28 08:53 作者: 令人苦惱 時間: 2025-3-28 11:29
Three-Dimensional Biohybrid StarPEG–Heparin Hydrogel Cultures for Modeling Human Neuronal Developmen-based 3D cell culture system, in a hydrogel, that can be used to study human neuronal development and Alzheimer’s disease (AD) pathology. A 3D cell culture system can mimic the in vivo cellular environment better than a 2D format, in which these cells exhibit neural network formation, electrophysio作者: Dorsal 時間: 2025-3-28 15:26
Computational Approaches to Assess Abnormal Metabolism in Alzheimer’s Disease Using TranscriptomicsTranscriptome integration leads to identification of metabolic reactions that are differentially inactivated in the tissue of interest. Among the methods available for mapping transcriptome data on GEMs, we focus here on an Integrative Metabolic Analysis Tool (iMAT), which we have recently applied t作者: 從屬 時間: 2025-3-28 20:16 作者: Synthesize 時間: 2025-3-28 23:23 作者: ALIAS 時間: 2025-3-29 04:08 作者: monologue 時間: 2025-3-29 11:01 作者: Basilar-Artery 時間: 2025-3-29 13:31 作者: Manifest 時間: 2025-3-29 17:15 作者: temperate 時間: 2025-3-29 22:21 作者: Preamble 時間: 2025-3-30 03:31 作者: 沒有希望 時間: 2025-3-30 07:08 作者: TSH582 時間: 2025-3-30 11:24
https://doi.org/10.1007/978-3-663-20308-7es and functional states in both healthy and diseased brains. To exploit fully the technologies available for such studies, one must extract and isolate pure nuclei from unfixed postmortem tissue while preserving the molecules to be interrogated. Currently, nuclei are necessary substitutes for indiv作者: 邪惡的你 時間: 2025-3-30 14:35
https://doi.org/10.1007/978-3-663-06775-7rains. The method is suitable for brain slices consisting of both gray and white matter..The ability to concomitantly isolate vascular cells with glial cells provides the opportunity to investigate multiple cell types originating from the same donor. This represents a novel approach for . research, 作者: patella 時間: 2025-3-30 19:24
