作者: 流眼淚 時(shí)間: 2025-3-21 23:56
,The Genetics of Alzheimer’s Disease,r’s disease as occurring in the presenium. The same neuropathological changes occurring in brains over the age of 65 were called “senile dementia.” Because there have been no clinical or pathological features to separate the two groups, this somewhat arbitrary distinction has been abandoned. Althoug作者: Cardioplegia 時(shí)間: 2025-3-22 01:15 作者: gimmick 時(shí)間: 2025-3-22 06:08 作者: dictator 時(shí)間: 2025-3-22 12:38
,Quantifying Aβ1–40 and Aβ1–42 Using Sandwich-ELISA,ecursor protein (APP) that alter Aβ production are linked to a subset of familial AD (FAD) cases with autosomal penetrance (reviewed in .. .). Several of these FAD-associated APP mutations, as well as FAD-associated mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes, lead to an increas作者: 切碎 時(shí)間: 2025-3-22 15:09 作者: growth-factor 時(shí)間: 2025-3-22 19:54 作者: incredulity 時(shí)間: 2025-3-22 23:18
,Effects of the β-Amyloid Peptide on Membrane Ion Permeability, electrophysiological techniques that can be employed to isolate and record specific membrane conductances that may be altered by Aβ. In general, an increase in conductances that cause depolarization of the cell membrane may be considered excitotoxic since they will: (.) increase Ca.influx through v作者: 遺留之物 時(shí)間: 2025-3-23 04:53 作者: 拘留 時(shí)間: 2025-3-23 08:08
Posttranslational Modifications of Amyloid Precursor Protein,ail (.). Translation of APP occurs at the endoplasmic reticulum (ER) and the protein is translocated into the ER lumen. The N-terminal domain of APP is directed towards the luminal compartment of the ER, whereas the C-terminal domain faces the cytoplasm. After synthesis, APP passes from the ER to th作者: maverick 時(shí)間: 2025-3-23 10:09 作者: delta-waves 時(shí)間: 2025-3-23 14:28 作者: 松軟 時(shí)間: 2025-3-23 20:03
,Inhibition of α-Secretase by Zinc Metalloproteinase Inhibitors, the β-amyloid (Aβ) peptide by β-secretase and at the C-terminus by one or more γ-secretases constitutes the amyloidogenic pathway. In the nonamyloidogenic pathway, α-secretase cleaves APP within the Aβ peptide between Lys16 and Leu17 (numbering from the N-terminus of the Aβ peptide) (.), thereby pr作者: 作繭自縛 時(shí)間: 2025-3-24 00:51
,Development of Neoepitope Antibodies Against the β-Secretase Cleavage Site in the Amyloid Precursorin (APP) has eluded many researchers. This is largely because the measurement of the various APP processing products is technically challenging owing to their low levels of production in in vitro and in vivo test systems. Sequence analysis of products in cell cultures, cerebrospinal fluid (CSF), and作者: iodides 時(shí)間: 2025-3-24 03:08 作者: enormous 時(shí)間: 2025-3-24 08:03
,Using β-Secretase Inhibitors to Distiguish the Generation of the Aβ Peptides Terminating at Val-40 c and toxicity requires the formation of amyloid fibrils similar to those found in senile plaques (.). Autosomal dominant mutations linked to Alzheimer’s disease were identified in three different genes (. .). All mutations apparently alter amyloid precursor protein (APP) metabolism to increase the 作者: Incumbent 時(shí)間: 2025-3-24 14:24 作者: accessory 時(shí)間: 2025-3-24 17:38 作者: reaching 時(shí)間: 2025-3-24 22:10 作者: Volatile-Oils 時(shí)間: 2025-3-25 01:13 作者: flaggy 時(shí)間: 2025-3-25 06:27
https://doi.org/10.1007/978-3-662-26346-4nile dementia” compared with dizygotic twins and siblings. This monozygotic excess has been confirmed in studies applying more rigorous diagnostic criteria although there may be widely disparate ages of onset between twins (.). The most convincing evidence for a genetic contribution to AD has come f作者: 多嘴多舌 時(shí)間: 2025-3-25 11:32
https://doi.org/10.1007/978-3-531-94207-0ically processed in a way that does not produce (and, in fact, precludes) Aβ. This “α-secretase” event cleaves within the Aβ sequence and liberates most of the extracellular portion (sAPPα) of APP from the cell surface .). Because the “β-secretase” event required for the generation of Aβ creates a d作者: FID 時(shí)間: 2025-3-25 11:55
https://doi.org/10.1007/978-3-531-94207-0aradigms. Here we describe the use of a highly sensitive sandwich-ELISA (enzyme-linked immunosorbent assay) to quantitate both Aβ.–. and Aβ.–. in soluble pools, after secretion by cultured cells into the medium or in human cerebrospinal fluid (CSF) samples, as well as in insoluble pools, as found in作者: 合乎習(xí)俗 時(shí)間: 2025-3-25 17:38 作者: obviate 時(shí)間: 2025-3-25 23:36 作者: 共同給與 時(shí)間: 2025-3-26 04:13 作者: Headstrong 時(shí)間: 2025-3-26 08:00
https://doi.org/10.1007/978-3-662-02210-8imer’s disease. Regulation of the balance of APP processing by the amyloidogenic and nonamyloidogenic pathways through either selective inhibition of β- and γ-secretases or activation of α-secretase can all be considered as potential therapeutic approaches. As a first step towards isolating the APP 作者: BACLE 時(shí)間: 2025-3-26 08:41 作者: 朋黨派系 時(shí)間: 2025-3-26 15:07
Die Messung kaufbegleitender Emotionen,. The second approach is based on selective permeabilization of the plasma membrane using a bacterial pore-forming toxin, streptolysin-O (SLO), and subsequent immunocytochemical probing for cytosolic epitopes using specific antibodies. Both of these methods can be easily adapted to determine the top作者: 變形 時(shí)間: 2025-3-26 20:11
1543-1894 ursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.978-1-61737-161-5978-1-59259-195-4Series ISSN 1543-1894 Series E-ISSN 1940-6037 作者: 調(diào)情 時(shí)間: 2025-3-27 00:13
,Introduction to Alzheimer’s Disease,europathological findings. It was Divry (.) who first demonstrated the presence of amyloid at the center of the senile plaque, by means of Congo red staining. All amyloid deposits were originally thought to be starch-like in nature (hence the name), but it is now apparent that they are formed from a作者: deriver 時(shí)間: 2025-3-27 03:34
,The Genetics of Alzheimer’s Disease,nile dementia” compared with dizygotic twins and siblings. This monozygotic excess has been confirmed in studies applying more rigorous diagnostic criteria although there may be widely disparate ages of onset between twins (.). The most convincing evidence for a genetic contribution to AD has come f作者: Synapse 時(shí)間: 2025-3-27 06:10 作者: 合法 時(shí)間: 2025-3-27 10:56 作者: gout109 時(shí)間: 2025-3-27 15:45
,Electrophoretic Separation and Immunoblotting of Aβ1–40 and Aβ1–42,β42 isoform (.-.). These observations have led to the hypothesis that Aβ42 may play a critical role in amyloid plaque formation and the development of Alzheimer’s disease. Obviously methods discriminating between the two major Aβ species are important in order to study this notion.作者: 珊瑚 時(shí)間: 2025-3-27 18:52 作者: 動(dòng)作謎 時(shí)間: 2025-3-27 22:51
Posttranslational Modifications of Amyloid Precursor Protein,y on translocation into the ER, the signal peptide of APP is removed from the N-terminus by signal peptidase. APP is then modified cotranslationally by N-glycosylation on NH.-groups of asparagine residues. After passage into the Golgi compartment, the ectodomain of APP is subjected to O-glycosylatio作者: Capture 時(shí)間: 2025-3-28 04:42 作者: 慟哭 時(shí)間: 2025-3-28 09:01
,Using β-Secretase Inhibitors to Distiguish the Generation of the Aβ Peptides Terminating at Val-40 PP with a mutation at codon 717 known to increase the formation of Aβ42 led to the appearance of Aβ deposits at the age of 18 mo. These data suggest that the Aβ load in the brain as well as the amyloidogenic properties of the Aβ isoforms directly regulate deposition and senile plaque formation.作者: Alopecia-Areata 時(shí)間: 2025-3-28 13:51
Determining the Transmembrane Topology of the Presenilins,. The second approach is based on selective permeabilization of the plasma membrane using a bacterial pore-forming toxin, streptolysin-O (SLO), and subsequent immunocytochemical probing for cytosolic epitopes using specific antibodies. Both of these methods can be easily adapted to determine the top作者: 陰謀小團(tuán)體 時(shí)間: 2025-3-28 18:22 作者: 消滅 時(shí)間: 2025-3-28 20:27
https://doi.org/10.1007/978-3-322-98663-4fect. This is a simplistic view, as it has been shown that for certain forms of apoptosis an increase in hyperpolarizing K.currents may be involved (.). It is, therefore, important to consider the functional effects of any changes in membrane conductances or ion channel currents induced by Aβ in the light of neurotoxic effects of the peptide.作者: 無(wú)法治愈 時(shí)間: 2025-3-29 02:37
Walter Baumeister,Helmut Burghardtc domain, except that unlike APP, APP-like proteins lack the β-amyloid sequence. It has been thought that APP and APLP2 have a similar physiological function (.). In contrast, APLP1 is believed to differ functionally from APP and APLP2, although the physiological functions of these APP family proteins have not yet been well analyzed.作者: 知識(shí) 時(shí)間: 2025-3-29 05:44
,Effects of the β-Amyloid Peptide on Membrane Ion Permeability,fect. This is a simplistic view, as it has been shown that for certain forms of apoptosis an increase in hyperpolarizing K.currents may be involved (.). It is, therefore, important to consider the functional effects of any changes in membrane conductances or ion channel currents induced by Aβ in the light of neurotoxic effects of the peptide.作者: 墻壁 時(shí)間: 2025-3-29 10:31 作者: 不出名 時(shí)間: 2025-3-29 11:29
Book 2000e played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.作者: 大看臺(tái) 時(shí)間: 2025-3-29 15:47
https://doi.org/10.1007/978-3-322-98856-0the deposition of multimeric Aβ fibrils into plaques is a necessary step in AD onset, there is still uncertainty as to how Aβ and neuritic plaques might cause the neuropathology that leads to the dementia that is characteristic of this disease.作者: 同步左右 時(shí)間: 2025-3-29 20:04 作者: 性冷淡 時(shí)間: 2025-3-30 01:23
https://doi.org/10.1007/978-3-662-26346-4ss visible but equally important advance has been a quantum leap in expertise in clinical trial methodology. This chapter reviews the methodological underpinnings of clinical trials in AD: patient selection issues, key design issues, and an overview of currently available agents and the prospects for drugs of the future.作者: Coronary 時(shí)間: 2025-3-30 08:02 作者: Inclement 時(shí)間: 2025-3-30 10:07 作者: 商議 時(shí)間: 2025-3-30 13:01 作者: 轉(zhuǎn)向 時(shí)間: 2025-3-30 20:20
Posttranslational Modifications of the Amyloid Precursor Protein,er provides methods for analyzing the glycosylation of APP that is actively synthesized by living cells in tissue culture. These methods can be applied to primary cultures, continuous cell lines, and transfected cell lines expressing recombinant APP.作者: medium 時(shí)間: 2025-3-30 21:45
,Development of Neoepitope Antibodies Against the β-Secretase Cleavage Site in the Amyloid Precursorptide from APP (. .). More routine identification of the secretase activities has relied on the specificity and sensitivity of antibodies raised to the predicted cleavage products and has been impeded by the difficulties associated with the generation of such reagents.作者: incite 時(shí)間: 2025-3-31 01:49 作者: Synapse 時(shí)間: 2025-3-31 05:32 作者: 粗野 時(shí)間: 2025-3-31 11:26
https://doi.org/10.1007/978-3-662-02210-8 cleavages govern the level of Aβ generated from the amyloid precursor protein (APP). β- and γ-cleavages at the amino and carboxyl termini of Aβ produce amyloidogenic peptides; in contrast, α-cleavage within the Aβ domain destroys the amyloidogenic potential of APP. The proteases responsible for these cleavages have not been identified.作者: countenance 時(shí)間: 2025-3-31 16:08 作者: Impugn 時(shí)間: 2025-3-31 19:07 作者: legitimate 時(shí)間: 2025-3-31 23:55 作者: 大罵 時(shí)間: 2025-4-1 02:59 作者: PLAYS 時(shí)間: 2025-4-1 06:57 作者: Creatinine-Test 時(shí)間: 2025-4-1 13:00
Methods in Molecular Medicinehttp://image.papertrans.cn/a/image/154257.jpg作者: Legion 時(shí)間: 2025-4-1 16:58 作者: morale 時(shí)間: 2025-4-1 18:36
