標題: Titlebook: Alternatives for Dermal Toxicity Testing; Chantra Eskes,Erwin van Vliet,Howard I. Maibach Book 2017 Springer International Publishing AG 2 [打印本頁] 作者: 兇惡的老婦 時間: 2025-3-21 18:13
書目名稱Alternatives for Dermal Toxicity Testing影響因子(影響力)
書目名稱Alternatives for Dermal Toxicity Testing影響因子(影響力)學科排名
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書目名稱Alternatives for Dermal Toxicity Testing網(wǎng)絡(luò)公開度學科排名
書目名稱Alternatives for Dermal Toxicity Testing被引頻次
書目名稱Alternatives for Dermal Toxicity Testing被引頻次學科排名
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書目名稱Alternatives for Dermal Toxicity Testing年度引用學科排名
書目名稱Alternatives for Dermal Toxicity Testing讀者反饋
書目名稱Alternatives for Dermal Toxicity Testing讀者反饋學科排名
作者: Lineage 時間: 2025-3-21 23:37 作者: 星星 時間: 2025-3-22 01:45 作者: 機械 時間: 2025-3-22 05:12 作者: 魔鬼在游行 時間: 2025-3-22 10:10
https://doi.org/10.1007/978-3-8349-9707-4on centers and regulators, several in vitro test methods have been developed, validated and regulatory adopted as potential replacements of the rabbit skin irritation test..This chapter describes in details the skin irritation test (SIT) based on the use of the in vitro reconstructed human epidermis作者: 消滅 時間: 2025-3-22 13:30 作者: 我正派 時間: 2025-3-22 18:25
https://doi.org/10.1007/978-3-8349-9707-4consists of normal human epidermal keratinocytes whose biological origin is neonatal foreskin. The several validation studies of the . skin irritation test method using LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) were conducted at three laboratories to assess both intra- and interlaboratory reprod作者: Fermentation 時間: 2025-3-22 23:30
https://doi.org/10.1007/978-3-8349-9707-4duction, these cells differentiate in a multilayered epidermis that serves as a model for human . epidermis. For the epiCS. SIT method, the tissues are exposed to test substances for 20 min followed by a 42 h post-incubation period. Subsequently, the relative viability of the tissues is determined b作者: 有組織 時間: 2025-3-23 03:19
https://doi.org/10.1007/978-3-8349-9707-4ve been validated and adopted in the regulation as early as 2000 in the European Union and in 2004 at the OECD level. Current internationally agreed approaches recommend the use of Integrated Approach for Testing and Assessment (IATA) that allow to replace or minimize to the extent possible the use 作者: 沒花的是打擾 時間: 2025-3-23 08:24
https://doi.org/10.1007/978-3-8349-9707-4od has been shown to be robust, transferable, and reproducible in validation studies organised with three laboratories. The overall accuracy of the EpiSkin? test method in distinguishing between corrosive and non-corrosive chemicals was 92.4% with a large set of 113 chemicals through a systematic . 作者: Sciatica 時間: 2025-3-23 12:36
https://doi.org/10.1007/978-3-8349-9707-4emicals. Testing for skin corrosion in vivo causes suffering and pain to the test animals. A number of alternative approaches for the assessment of skin corrosion have been developed in the past three decades and some of the assays gained regulatory acceptance as replacements of the rabbit skin corr作者: 手術(shù)刀 時間: 2025-3-23 15:16
https://doi.org/10.1007/978-3-662-33311-2-corrosive chemicals as well for identifying UN GHS subcategories 1A and 1B and 1C within the context of Organization for Economic Co-operation and Development Test Guideline 431 (OECD TG 431). The within- and between-laboratory concordance of classifications between runs was found to be ≥92.5% for 作者: 長矛 時間: 2025-3-23 20:22 作者: 媒介 時間: 2025-3-23 22:11 作者: Cumbersome 時間: 2025-3-24 05:05 作者: Ballad 時間: 2025-3-24 07:16
https://doi.org/10.1007/978-3-531-93163-0spite these advances, more efforts are still needed to refine the existing methods and to further develop new methods that lead to an improved awareness of the real mechanisms of a chemical in triggering a sensitization reaction in exposed human beings. An important observation is that detailed anal作者: Fretful 時間: 2025-3-24 11:35
https://doi.org/10.1007/978-3-642-50879-0 by the challenges of regulatory acceptance, and so provided lessons for the entire process. What ensued has been instructive for test developers and those involved in validation and acceptance: widespread use of the LLNA led to questions and challenges not anticipated in the development and validat作者: superfluous 時間: 2025-3-24 18:36 作者: 打包 時間: 2025-3-24 22:57
https://doi.org/10.1007/978-3-663-09669-6ositex assigns chemicals both to UN packing groups I, II, III and Non-corrosive, and to GHS corrosive subcategories 1A, 1B, 1C (accepting “not Catergory 1” results also). The degree of corrosivity potential of a chemical is predicted by measuring its penetration time through calibrated biobarriers into a chemical detection system.作者: 船員 時間: 2025-3-24 23:21
Chantra Eskes,Erwin van Vliet,Howard I. MaibachProvides in-depth information on the alternatives to animal testing.Identifies the most suitable test method(s) for specific uses and endpoints.Describes the regulatory acceptance, protocols, performa作者: SLING 時間: 2025-3-25 04:47
http://image.papertrans.cn/a/image/154155.jpg作者: 不如屎殼郎 時間: 2025-3-25 09:11
The In Vitro Membrane Barrier Test Corrositex, for Skin Corrosionositex assigns chemicals both to UN packing groups I, II, III and Non-corrosive, and to GHS corrosive subcategories 1A, 1B, 1C (accepting “not Catergory 1” results also). The degree of corrosivity potential of a chemical is predicted by measuring its penetration time through calibrated biobarriers into a chemical detection system.作者: extinct 時間: 2025-3-25 14:03 作者: infringe 時間: 2025-3-25 17:53 作者: 憤憤不平 時間: 2025-3-25 20:23
The EpiDerm? Skin Irritation Test (EpiDerm? SIT)on centers and regulators, several in vitro test methods have been developed, validated and regulatory adopted as potential replacements of the rabbit skin irritation test..This chapter describes in details the skin irritation test (SIT) based on the use of the in vitro reconstructed human epidermis作者: drusen 時間: 2025-3-26 00:55
An , Skin Irritation Test Using the SkinEthic? Reconstructed Human Epidermal (RHE) Modeltation properties of chemicals (OECD TG 439). The SkinEthic? RHE skin irritation test method has been shown to be robust and transferable. The reproducibility and predictivity of the SkinEthic? RHE assay have been evaluated in validation studies organized with three laboratories, and with a set of 2作者: 有雜色 時間: 2025-3-26 06:06 作者: badinage 時間: 2025-3-26 12:17
The epiCS? Skin Irritation Test (SIT) Methodduction, these cells differentiate in a multilayered epidermis that serves as a model for human . epidermis. For the epiCS. SIT method, the tissues are exposed to test substances for 20 min followed by a 42 h post-incubation period. Subsequently, the relative viability of the tissues is determined b作者: 高度贊揚 時間: 2025-3-26 14:01 作者: Guaff豪情痛飲 時間: 2025-3-26 17:05
The EpiSkin? Human Epidermis Model for In Vitro Skin Corrosion of Test Chemicalsod has been shown to be robust, transferable, and reproducible in validation studies organised with three laboratories. The overall accuracy of the EpiSkin? test method in distinguishing between corrosive and non-corrosive chemicals was 92.4% with a large set of 113 chemicals through a systematic . 作者: CBC471 時間: 2025-3-26 21:26 作者: 紀念 時間: 2025-3-27 04:34 作者: Aerate 時間: 2025-3-27 08:03
The epiCS? Skin Corrosion Test Methodrding to OECD TG 431. Recently, the EU Classification, Labelling and Packaging Regulation (EU CLP) system required the subcategorization of corrosive chemicals into the UN GHS optional subcategories 1A and 1B and 1C. Eighty chemicals including solids, semi-solids and liquids of different chemical cl作者: Electrolysis 時間: 2025-3-27 11:18 作者: gustation 時間: 2025-3-27 15:25 作者: BARGE 時間: 2025-3-27 17:50
Overview on Current Status and Combination of Test Methodsspite these advances, more efforts are still needed to refine the existing methods and to further develop new methods that lead to an improved awareness of the real mechanisms of a chemical in triggering a sensitization reaction in exposed human beings. An important observation is that detailed anal作者: 脫離 時間: 2025-3-27 23:51 作者: 歡樂中國 時間: 2025-3-28 03:49
Utilization of Peptide Reactivity Assays for the Prediction of Skin Sensitizationns with proteins has long been established as a key step in induction of skin sensitization. Based on this, two . approaches have been developed: the Direct Peptide Reactivity Assay (DPRA) and the Peroxidase Peptide Reactivity Assay (PPRA). Both assays utilize synthetic peptides which contain either作者: Cardiac-Output 時間: 2025-3-28 09:37 作者: 取消 時間: 2025-3-28 11:22
https://doi.org/10.1007/978-3-8349-9707-4tained during the validation study. Part of this chapter also describes other EpiDerm? skin irritation protocols that can be used for the safety assessment of final cosmetic products and for testing extracts from Medical Devices in line with the ISO 10993.作者: brachial-plexus 時間: 2025-3-28 16:40
https://doi.org/10.1007/978-3-8349-9707-4ormation concerning the skin irritation properties of the tested chemical and be used in combination with a battery of assays, such as the SkinEthic? RHE skin corrosion method, in any initiative aimed at developing integrated testing strategies for full evaluation of local skin effects.作者: meditation 時間: 2025-3-28 21:37 作者: 蠟燭 時間: 2025-3-29 02:45 作者: plasma-cells 時間: 2025-3-29 03:42
https://doi.org/10.1007/978-3-662-33311-2D reference chemicals as recommended in the OECD TG 431, the subcategorization accuracy (i.e. predictive capacity) achieved was 70.8%. Furthermore, due to its high sensitivity and the negligible under-classification, the test method provides high safety standards for skin corrosion testing.作者: 天真 時間: 2025-3-29 11:12 作者: 繼而發(fā)生 時間: 2025-3-29 14:26
Skin Irritation Hazard of Chemicals Assessed by the EpiSkin? , Test Method of the tested chemical and be used in combination with a battery of assays, such as the EpiSkin? skin corrosion method, in any initiative aimed at developing integrated testing strategies for full evaluation of local skin effects.作者: MAG 時間: 2025-3-29 18:16 作者: 懲罰 時間: 2025-3-29 22:54 作者: 誓言 時間: 2025-3-30 01:53
The EpiSkin? Human Epidermis Model for In Vitro Skin Corrosion of Test Chemicalse EURL-ECVAM data. It could be regarded as a primary source of information concerning the skin corrosion properties of the tested chemical and be used in combination with a battery of assays, such as the EpiSkin? skin irritation method, in any initiative aimed at developing integrated testing strategies for full evaluation of local skin effects.作者: bile648 時間: 2025-3-30 05:17
The EpiDerm? Skin Corrosion Test (EpiDerm? SCT)els. The chapter focuses on the technical details of this assay, provides information about the performance of the test method during the validation study and discusses the adapted protocol derived from an OECD follow up work to improve the prediction model of RhE models for the sub-categorization of corrosive sub-classes.作者: 使高興 時間: 2025-3-30 12:02
Assessment of the Human Epidermis SkinEthic? RHE Model for , Skin Corrosion Testing of ChemicalsD reference chemicals as recommended in the OECD TG 431, the subcategorization accuracy (i.e. predictive capacity) achieved was 70.8%. Furthermore, due to its high sensitivity and the negligible under-classification, the test method provides high safety standards for skin corrosion testing.作者: eustachian-tube 時間: 2025-3-30 13:41 作者: Odyssey 時間: 2025-3-30 16:34
Book 2017sses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.作者: HARD 時間: 2025-3-30 21:05 作者: 形上升才刺激 時間: 2025-3-31 02:25 作者: 裂口 時間: 2025-3-31 05:43 作者: 真繁榮 時間: 2025-3-31 11:27
Book 2017ry, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scie作者: RAFF 時間: 2025-3-31 13:55 作者: 忘川河 時間: 2025-3-31 17:37
https://doi.org/10.1007/978-3-8349-9707-4ghting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from . skin irritation assays. The LabCyte EPI-MODEL24 is included in OECD TG 439 . skin irritation: reconstructed human epidermis test method, which also provides information作者: right-atrium 時間: 2025-4-1 00:43
