作者: 過份好問 時間: 2025-3-22 00:05
Probing the active site of mammalian pyruvate dehydrogenase, reactions: the thiamin pyrophosphate (TPP)-dependent decarboxylation of pyruvic acid to 2-hydroxyethylidene-TPP (HETPP) [Eq. 1] and reductive acetylation of lipoic acid residues covalently linked to the second catalytic component — dihydrolipoamide acetyltransferase (E2) [Eq. 2] (Reed, 1974): . Mam作者: Ascendancy 時間: 2025-3-22 00:41
Role of the E2 core in the dominant mechanisms of regulatory control of mammalian pyruvate dehydrogs execute the overall reaction through a series of steps linked by cofactor-mediated active site coupling: the pyruvate dehydrogenase component (E1); the dihydrolipoyl acetyltransferase component (E2); the dihydrolipoyl dehydrogenase component (E3); and the E3-binding component (E3BP, previously pro作者: LATER 時間: 2025-3-22 07:40 作者: 過剩 時間: 2025-3-22 09:35
Plant pyruvate dehydrogenase complexes,uirements have led to increasing diversity between these two classes of eukaryotes. Analyses of the pyruvate dehydrogenase complex (PDC) in plant cells serve to illustrate both the similarities inherent in pyruvate metabolism and differences dictated by the need to respond to diverse external stimul作者: CULP 時間: 2025-3-22 14:42 作者: 語源學 時間: 2025-3-22 19:46 作者: Clinch 時間: 2025-3-22 22:30 作者: 手勢 時間: 2025-3-23 04:11 作者: corpuscle 時間: 2025-3-23 08:10
,The mitochondrial α-ketoacid dehydrogenase kinases: Molecular cloning, tissue-specific expression arotein kinases (Popov et al., 1992; Popov et al., 1993; Popov et al., 1994). The first of these enzymes to be cloned (Popov et al., 1992), the branched chain α-ketoacid dehydrogenase kinase (BDK), phosphorylates and inactivates the branched-chain α-ketoacid dehydrogenase complex (BCKDC), the rate-li作者: Ophthalmologist 時間: 2025-3-23 13:35
Shorter term and longer term regulation of pyruvate dehydrogenase kinases,The reaction connects glycolysis to oxidative metabolism, and to FFA synthesis, resulting in the irretrievable loss of glucose carbon (animals lack the means of converting acetylCoA to glucose). Some cells in the central nervous system are critically dependent upon glucose oxidation for survival and作者: 沉積物 時間: 2025-3-23 14:39 作者: Diastole 時間: 2025-3-23 21:31
,Regulation of branched-chain α-keto acid dehydrogenase complex in rat liver and skeletal muscle by g step in the catabolism of branched-chain amino acids. The enzyme complex is subject to covalent modification; a phosphorylation / dephosphorylation cycle regulates the enzyme activity. It has been reported that dietary protein has a great effect on the activity state of the enzyme complex in rat l作者: Congregate 時間: 2025-3-23 23:24 作者: 拖網(wǎng) 時間: 2025-3-24 06:15
Long-term regulation and promoter analysis of mammalian pyruvate dehydrogenase complex,ds to form acetyl-CoA in the mitochondria. Acetyl-CoA is then utilized for either energy production by the tricarboxylic acid cycle or energy storage by the lipogenic pathway. This enzyme complex contains multiple copies of three catalytic components: pyruvate dehydrogenase (E1), dihydrolipoamide ac作者: 故意 時間: 2025-3-24 09:17 作者: avulsion 時間: 2025-3-24 13:43 作者: 一個攪動不安 時間: 2025-3-24 17:34
Human defects of the pyruvate dehydrogenase complex,in the intrauterine environment where energy production depends primarily on glucose oxidation. The now well-established occurrence of these defects presents a challenge to provide physiological explanations of what factors determine survival and adaptation of affected individuals. Unfortunately, fo作者: exhibit 時間: 2025-3-24 22:03
Multigenic basis for maple syrup urine disease with emphasis on mutations in branched chain dihydroto “run in families”(Garrod, 1908, 1923). By the 1950s, this understanding extended to knowing specific enzyme defects for several inborn errors. Thus, the stage was set for describing new disorders of which maple syrup urine disease (MSUD) was one. MSUD was first described clinically in 1954 by Men作者: maladorit 時間: 2025-3-25 02:01 作者: HEPA-filter 時間: 2025-3-25 06:58 作者: 四牛在彎曲 時間: 2025-3-25 11:23 作者: 無目標 時間: 2025-3-25 14:48 作者: 捕鯨魚叉 時間: 2025-3-25 19:14
978-3-0348-9853-9Birkh?user Verlag 1996作者: 意外 時間: 2025-3-25 22:14 作者: FATAL 時間: 2025-3-26 01:16
https://doi.org/10.1007/978-3-7091-5835-7 reactions: the thiamin pyrophosphate (TPP)-dependent decarboxylation of pyruvic acid to 2-hydroxyethylidene-TPP (HETPP) [Eq. 1] and reductive acetylation of lipoic acid residues covalently linked to the second catalytic component — dihydrolipoamide acetyltransferase (E2) [Eq. 2] (Reed, 1974): . Mam作者: fulcrum 時間: 2025-3-26 05:33
https://doi.org/10.1007/978-3-7091-5835-7s execute the overall reaction through a series of steps linked by cofactor-mediated active site coupling: the pyruvate dehydrogenase component (E1); the dihydrolipoyl acetyltransferase component (E2); the dihydrolipoyl dehydrogenase component (E3); and the E3-binding component (E3BP, previously pro作者: myocardium 時間: 2025-3-26 11:02 作者: 離開 時間: 2025-3-26 13:16
,Some Exact Results on π π Scattering,uirements have led to increasing diversity between these two classes of eukaryotes. Analyses of the pyruvate dehydrogenase complex (PDC) in plant cells serve to illustrate both the similarities inherent in pyruvate metabolism and differences dictated by the need to respond to diverse external stimul作者: BRINK 時間: 2025-3-26 19:40
Lectures on Regge Phenomenology,ita, 1992; Komuniecki and Komuniecki, 1995). Adult ascarid muscle mitochondria use unsaturated organic acids, instead of oxygen, as terminal electron-acceptors and acetate, propionate, succinate, and the 2-methyl branched-chain fatty acids, 2-methylbutyrate and 2-methylvalerate, accumulate as end pr作者: 建筑師 時間: 2025-3-26 21:56 作者: Musket 時間: 2025-3-27 02:55
Developments in High Energy Physicsse complexes, X component (the dihydrolipoamide dehydrogenase-binding protein) of the eucaryotic pyruvate dehydrogenase complex, and H-protein of the glycine cleavage system. The lipoyl moiety is attached in amide linkage to the ε-amino group of specific lysine residues of the proteins. Although the作者: 背信 時間: 2025-3-27 09:10
,Some Exact Results on π π Scattering, to activators and inhibitors (Cohen, 1989; Shenolikar and Nairn, 1991). Protein phosphatase 1 is sensitive to the thermostable proteins inhibitor 1 and inhibitor 2, and protein phosphatases 1 and 2A are sensitive to okadaic acid. Protein phosphatase 2B is Ca./calmodulin-regulated and protein phosph作者: 階層 時間: 2025-3-27 11:00 作者: Deference 時間: 2025-3-27 16:33 作者: 恭維 時間: 2025-3-27 21:51
The Merchant Looks at Microbiologywell as short-term effects of starvation and diabetes to suppress glucose oxidation, long-term regulatory mechanisms impose an upper limit on the overall capacity for glucose oxidation and introduce latency of reactivation of glucose oxidation when a high-carbohydrate, low-fat meal is provided, or w作者: 教育學 時間: 2025-3-27 22:20
The Merchant Looks at Microbiologyg step in the catabolism of branched-chain amino acids. The enzyme complex is subject to covalent modification; a phosphorylation / dephosphorylation cycle regulates the enzyme activity. It has been reported that dietary protein has a great effect on the activity state of the enzyme complex in rat l作者: 支架 時間: 2025-3-28 04:01
Adaptation of Microorganisms to Radiation increase in the dephosphorylated (active) form of the enzyme (Jungas, 1971; Linn, Pettit and Reed, 1969). MaCauley and Jarett (1985) demonstrated that the specific interconverting enzyme under insulin control was its phosphatase. They clearly demonstrated that a substance was produced when insulin 作者: 我邪惡 時間: 2025-3-28 06:28 作者: Resign 時間: 2025-3-28 11:34
Olena Ivanochko,Jennifer R. Calhounnverted to metabolites which then can be used in energy-producing reactions. Although some energy can be, and is, generated by anaerobic metabolism (e.g., in glycolysis), most energy in mammalian cells is generated through aerobic energy production in the mitochondria. Nearly all tissues can use car作者: 寬容 時間: 2025-3-28 15:12
Studies in Systems, Decision and Control, BCAAs are either incorporated into proteins or are catabolized for energy (Danner and Elsas II, 1989). The BCAA are catabolized through analogous mechanisms for the first three steps: transamination, oxidative decarboxylation of the branched-chain α-keto acid (BCKA), and dehydrogenation of the res作者: Cosmopolitan 時間: 2025-3-28 18:53
Natalia Kryvinska,Michal Gregu?in the intrauterine environment where energy production depends primarily on glucose oxidation. The now well-established occurrence of these defects presents a challenge to provide physiological explanations of what factors determine survival and adaptation of affected individuals. Unfortunately, fo作者: 漫步 時間: 2025-3-29 02:38
Clara Baumgarten,Iryna Ivanochkoto “run in families”(Garrod, 1908, 1923). By the 1950s, this understanding extended to knowing specific enzyme defects for several inborn errors. Thus, the stage was set for describing new disorders of which maple syrup urine disease (MSUD) was one. MSUD was first described clinically in 1954 by Men作者: conference 時間: 2025-3-29 04:54 作者: Nonthreatening 時間: 2025-3-29 09:24
Non-Polynomial Lagrangian Theories, 2-electron reduced enzyme. Mutagenesis studies and the use of a modified flavin cofactor revealed the various factors involved in this stabilization in which also the core component of the complex has a function.作者: 刻苦讀書 時間: 2025-3-29 14:47 作者: 輕打 時間: 2025-3-29 19:25
,Some Exact Results on π π Scattering,atase 2C is Mg.-dependent. The protein serine/threonine phosphatases of known sequence comprise two distinct gene families, a major family that includes protein phosphatases 1, 2A, and 2B and isoforms thereof, and a smaller family that includes protein phosphatase 2C and pyruvate dehydrogenase (PDH) phosphatase.作者: linguistics 時間: 2025-3-29 19:48 作者: sulcus 時間: 2025-3-30 01:42
https://doi.org/10.1007/978-3-030-97008-6etytransferase (E2) and dihydrolipoamide dehydrogenase (E3), two regulatory components (E1-kinase, phospho-E1 phosphatase) and one non-catalytic protein X (also referred to as E3-binding protein) (for review see: Reed, 1974; Patel and Roche, 1990; Behal et al., 1993).作者: 破裂 時間: 2025-3-30 05:05 作者: Indurate 時間: 2025-3-30 11:25
Lipoamide dehydrogenase, 2-electron reduced enzyme. Mutagenesis studies and the use of a modified flavin cofactor revealed the various factors involved in this stabilization in which also the core component of the complex has a function.作者: 幾何學家 時間: 2025-3-30 15:44 作者: inveigh 時間: 2025-3-30 18:55 作者: 草本植物 時間: 2025-3-30 22:56
Shorter term and longer term regulation of pyruvate dehydrogenase kinases, conservation of glucose by substitution of lipid fuels in cells able to oxidise them is of vital importance during carbohydrate deprivation. Regulation of the PDH complex is therefore of crucial importance in glucose homeostasis.作者: 熟練 時間: 2025-3-31 01:30 作者: 危險 時間: 2025-3-31 06:17
,Molecular defects of the branched-chain α-keto acid dehydrogenase complex: Maple syrup urine diseasulting branched-chain acyl-coenzyme A (CoA) to enoyl CoA (Tanaka and Rosenberg, 1983). The oxidative decarboxylation of the BCKAs is performed by the branched-chain α-keto acid dehydrogenase complex (BCKDH), a constituent of all mammalian tissues which is associated with the mitochondrial inner membrane.作者: Mitigate 時間: 2025-3-31 12:30 作者: 他日關稅重重 時間: 2025-3-31 15:00 作者: 啪心兒跳動 時間: 2025-3-31 19:10
Hormonal and nutritional modulation of PDHC activity status,acteristics of the mitochondrial pyruvate dehydrogenase holocomplex (PDHC), which catalyses the oxidative decarboxylation of pyruvate to acetyl CoA. This chapter will review the regulation of PDHC by hormones and nutrients within the context of the competition between fatty acids (FA) and glucose as oxidative substrates.作者: Liability 時間: 2025-4-1 01:33 作者: Harridan 時間: 2025-4-1 04:07 作者: Pandemic 時間: 2025-4-1 09:36
https://doi.org/10.1007/978-3-7091-5835-7ontains TPP motif found by sequence comparison of several TPP requiring enzymes (Hawkins et al., 1989). Recent evidence indicates that both subunits are involved in TPP binding (Robinson and Chun, 1993; Ali et al., 1995; Korotchkina et al., 1995).作者: NAV 時間: 2025-4-1 11:33
,Some Exact Results on π π Scattering,ypical of the eukaryotic cell, where it serves as a primary entry point for carbon into the citric acid cycle. The plastid PDC provides the acetyl-CoA and NADH required for fatty acid and isoprenoid biosynthesis. Thus the first and most important mechanism for regulation of plant PDCs is compartmentalization of each of the enzymes.作者: 全部逛商店 時間: 2025-4-1 15:16 作者: 編輯才信任 時間: 2025-4-1 22:02
