標(biāo)題: Titlebook: Allostery; Methods and Protocol Luisa Di Paola,Alessandro Giuliani Book 2021 Springer Science+Business Media, LLC, part of Springer Nature [打印本頁] 作者: 弄混 時間: 2025-3-21 17:09
書目名稱Allostery影響因子(影響力)
書目名稱Allostery影響因子(影響力)學(xué)科排名
書目名稱Allostery網(wǎng)絡(luò)公開度
書目名稱Allostery網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Allostery被引頻次
書目名稱Allostery被引頻次學(xué)科排名
書目名稱Allostery年度引用
書目名稱Allostery年度引用學(xué)科排名
書目名稱Allostery讀者反饋
書目名稱Allostery讀者反饋學(xué)科排名
作者: Biomarker 時間: 2025-3-21 23:53 作者: seduce 時間: 2025-3-22 01:08 作者: dissent 時間: 2025-3-22 07:31
The Allosteric Effect in Antibody-Antigen Recognition,d the constant domain. We performed MD simulations of the complex of Fab and prion-associated peptide in the apo and bound forms and follow the conformational changes in the antibody and cross-talk between its subunits and with antigens. These protocols could be generally applied for studies of other antigens-antibody recognition systems.作者: modifier 時間: 2025-3-22 09:18
Book 2021 basic “machine-like” proteins, that are similar to “human machines,” need to be organized, architecturally, to relate to different organizational layers. Chapters cover topics such as methodological/computational factors focused on links between allostery and network formalism; the presence of osci作者: musicologist 時間: 2025-3-22 14:21 作者: 永久 時間: 2025-3-22 18:55
https://doi.org/10.1007/b101090 We mainly investigate four important networks by computing the number of connected components, the degree distribution, and assortativity measures. We compare each result in order to prove that the four networks have quite independent topologies.作者: 詩集 時間: 2025-3-22 22:08 作者: 熱心 時間: 2025-3-23 02:12
Development of Hedonic Of?ce Rent Indicespanied by cooperative interactions between RNA and its ligand, thus streamlining the folding and assembly pathways. This chapter provides an overview of the interplay between cooperativity and allostery in RNA systems and outlines methods to study these two biological principles.作者: 使成波狀 時間: 2025-3-23 07:10 作者: Cabinet 時間: 2025-3-23 10:44
International Series in Outreach Scholarshipng efforts to relate rate constants in the master equation to protein structural dynamics. Results for apomyoglobin involving relations between fluctuations in the length of hydrogen bonds and the energy flux between them are presented.作者: 鞠躬 時間: 2025-3-23 15:53
Culture and Emotional Development, the allosteric pathways. This method is complementary to network analyses based on different metrics and it is particularly powerful for studying large proteic systems, as it provides a coarse-grained view of the communication flows within large and complex networks.作者: MAIM 時間: 2025-3-23 19:15
Locating and Navigating Energy Transport Networks in Proteins,ng efforts to relate rate constants in the master equation to protein structural dynamics. Results for apomyoglobin involving relations between fluctuations in the length of hydrogen bonds and the energy flux between them are presented.作者: 拍下盜公款 時間: 2025-3-23 22:15
Community Network Analysis of Allosteric Proteins, the allosteric pathways. This method is complementary to network analyses based on different metrics and it is particularly powerful for studying large proteic systems, as it provides a coarse-grained view of the communication flows within large and complex networks.作者: CLAM 時間: 2025-3-24 03:06 作者: 憤怒事實 時間: 2025-3-24 07:45 作者: Hiatal-Hernia 時間: 2025-3-24 11:28 作者: inflate 時間: 2025-3-24 16:40
https://doi.org/10.1057/9780230624931d the constant domain. We performed MD simulations of the complex of Fab and prion-associated peptide in the apo and bound forms and follow the conformational changes in the antibody and cross-talk between its subunits and with antigens. These protocols could be generally applied for studies of other antigens-antibody recognition systems.作者: aerobic 時間: 2025-3-24 20:19 作者: Blazon 時間: 2025-3-25 00:55
Book 2021the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls..Thorough and practical, .Allostery: Methods and Protocols. is a valuable resource for any scientists and researcher interested in learning more abou作者: Peculate 時間: 2025-3-25 06:00
Disclosing Allostery Through Protein Contact Networks,e will demonstrate how a network-based representation of protein structure in terms of nodes (aminoacid residues) and edges (effective contacts between residues) is the natural language for getting rid of allosteric phenomena and, more in general, of protein structure/function relationships.作者: 外面 時間: 2025-3-25 10:26
Probing Allosteric Mechanism with Long-Range Rigidity Transmission Across Protein Networks,ostery (RTA) algorithm. The RTA algorithm and method are designed to predict if mechanical perturbation of rigidity, for example, due to ligand binding, at one site of the protein can transmit and propagate across a protein structure and in turn cause a change in available conformational degrees of 作者: 軍火 時間: 2025-3-25 14:39
Network Re-Wiring During Allostery and Protein-Protein Interactions: A Graph Spectral Approach,nd their repercussion on the overall protein organization (residue clustering) are highlighted. In this review, we adopt a graph spectral method to probe these subtle changes in a quantitative manner. Further, the power of this method is demonstrated for capturing re-ordering of side-chain interacti作者: 土產(chǎn) 時間: 2025-3-25 16:09
Distal Regions Regulate Dihydrofolate Reductase-Ligand Interactions,n shown?to?exert their effects through a network of correlated amino acids and these effects have been investigated by NMR, protein dynamics, and analysis of coupled amino acids. The experimental methods and the?findings that are reviewed here have broad implications for our understanding of enzyme 作者: upstart 時間: 2025-3-25 20:09
Investigating Conformational Dynamics and Allostery in the p53 DNA-Binding Domain Using Molecular Scofactor recruitment. The protocol can be extended to any other cases of study. Indeed, it does not necessarily apply only to the study of DNA-induced effects, but more broadly to the investigation of long-range effects induced by a biological partner that binds to a biomolecule of interest.作者: Hormones 時間: 2025-3-26 02:30
Molecular Dynamics Simulation Techniques as Tools in Drug Discovery and Pharmacology : A Focus on Aovercome limitations of MD, such as enhanced sampling MD simulations. In this chapter, classical MD and enhanced sampling MD simulations will be described, along with their application to drug discovery, with a focus on allosteric drugs.作者: MURKY 時間: 2025-3-26 07:59
https://doi.org/10.1007/978-94-009-4281-3e will demonstrate how a network-based representation of protein structure in terms of nodes (aminoacid residues) and edges (effective contacts between residues) is the natural language for getting rid of allosteric phenomena and, more in general, of protein structure/function relationships.作者: Galactogogue 時間: 2025-3-26 09:46
https://doi.org/10.1007/b101090ostery (RTA) algorithm. The RTA algorithm and method are designed to predict if mechanical perturbation of rigidity, for example, due to ligand binding, at one site of the protein can transmit and propagate across a protein structure and in turn cause a change in available conformational degrees of 作者: 彎曲的人 時間: 2025-3-26 15:59
International Series in Outreach Scholarshipnd their repercussion on the overall protein organization (residue clustering) are highlighted. In this review, we adopt a graph spectral method to probe these subtle changes in a quantitative manner. Further, the power of this method is demonstrated for capturing re-ordering of side-chain interacti作者: insincerity 時間: 2025-3-26 17:25
https://doi.org/10.1057/9780230624931n shown?to?exert their effects through a network of correlated amino acids and these effects have been investigated by NMR, protein dynamics, and analysis of coupled amino acids. The experimental methods and the?findings that are reviewed here have broad implications for our understanding of enzyme 作者: 贊成你 時間: 2025-3-26 21:30 作者: 粗魯?shù)娜?nbsp; 時間: 2025-3-27 02:09
Development of Hedonic Of?ce Rent Indicesovercome limitations of MD, such as enhanced sampling MD simulations. In this chapter, classical MD and enhanced sampling MD simulations will be described, along with their application to drug discovery, with a focus on allosteric drugs.作者: 狂亂 時間: 2025-3-27 06:47 作者: 精密 時間: 2025-3-27 12:25 作者: 石墨 時間: 2025-3-27 14:28 作者: macabre 時間: 2025-3-27 17:58 作者: poliosis 時間: 2025-3-27 22:47
Probing Allosteric Mechanism with Long-Range Rigidity Transmission Across Protein Networks,a perturbation event. Allostery, which has been coined the “second secret of life,” is a fundamental property of most dynamics proteins. Most of critical questions surrounding allostery are largely unresolved. One of the key puzzles is to describe the physical mechanism of distant coupled conformati作者: 得體 時間: 2025-3-28 05:44 作者: 諂媚于性 時間: 2025-3-28 10:05 作者: 閃光東本 時間: 2025-3-28 10:28
Topology Results on Adjacent Amino Acid Networks of Oligomeric Proteins,ks. The aim is to present many mathematical tools in order to understand the structures of proteins implicitly coded in such networks and subnetworks. We mainly investigate four important networks by computing the number of connected components, the degree distribution, and assortativity measures. W作者: 焦慮 時間: 2025-3-28 15:47 作者: 青石板 時間: 2025-3-28 19:01 作者: Seminar 時間: 2025-3-29 00:48 作者: Grandstand 時間: 2025-3-29 04:21 作者: 暫時休息 時間: 2025-3-29 08:51
Investigating Conformational Dynamics and Allostery in the p53 DNA-Binding Domain Using Molecular S the cells alive or to kill them through mechanisms such as apoptosis. To complicate this picture, cancer cells that express mutant p53 becomes addicted to the mutant activity, so that the mutant variant features a myriad of gain-of-function activities, opening different venues for therapy. This mak作者: 眉毛 時間: 2025-3-29 14:18 作者: NICHE 時間: 2025-3-29 19:21
Cooperativity and Allostery in RNA Systems,emical cues. Although initially used to describe the impact of small molecules on the conformation and activity of protein enzymes, the definition of this term has been significantly broadened to describe long-range conformational change of macromolecules in response to small or large effectors. Suc作者: macrophage 時間: 2025-3-29 22:54 作者: assail 時間: 2025-3-30 02:35
https://doi.org/10.1007/978-94-009-4281-3s’ showing a sensible adaptation to their environment by the production of appropriate behavior when facing a specific stimulus. This fact qualifies (from the ‘effector’ side) proteins as nanomachines working as catalysts, motors, or switches. However (from the sensor side), the need to single out t作者: 殖民地 時間: 2025-3-30 07:40 作者: 昆蟲 時間: 2025-3-30 08:30 作者: 柳樹;枯黃 時間: 2025-3-30 14:02
https://doi.org/10.1007/b101090a perturbation event. Allostery, which has been coined the “second secret of life,” is a fundamental property of most dynamics proteins. Most of critical questions surrounding allostery are largely unresolved. One of the key puzzles is to describe the physical mechanism of distant coupled conformati作者: monochromatic 時間: 2025-3-30 17:45 作者: Jingoism 時間: 2025-3-31 00:26
International Series in Outreach Scholarshipt about by minor perturbations by natural processes like binding of a ligand or protein-protein interaction. The challenge lies in capturing minute changes at the residue interaction level and following their propagation at local as well as global distances. While macromolecular effects of the pheno作者: 耐寒 時間: 2025-3-31 02:50 作者: ingestion 時間: 2025-3-31 07:42
Culture and Emotional Development,ssical molecular dynamics (MD) simulations, protein motions can be analysed by means of mutual information between pairs of amino acid residues, providing dynamical weighted networks that contains fundamental information of the communication among amino acids. The CNA method has been successfully ap作者: 不幸的人 時間: 2025-3-31 09:54 作者: Pituitary-Gland 時間: 2025-3-31 16:41
https://doi.org/10.1057/9780230624931 constant domains, which do not directly interact with antigens. Such effects are difficult to study experimentally; however, molecular dynamics simulations and subsequent residue interaction network analysis provide insight into the allosteric communication between the antigen-binding CDR region an