標題: Titlebook: Alcoholism: A Molecular Perspective; T. Norman Palmer Book 1991 Plenum Press, New York 1991 Calcium.Pathogene.calcium channels.enzymes.met [打印本頁] 作者: 欺侮 時間: 2025-3-21 17:07
書目名稱Alcoholism: A Molecular Perspective影響因子(影響力)
書目名稱Alcoholism: A Molecular Perspective影響因子(影響力)學科排名
書目名稱Alcoholism: A Molecular Perspective網(wǎng)絡公開度
書目名稱Alcoholism: A Molecular Perspective網(wǎng)絡公開度學科排名
書目名稱Alcoholism: A Molecular Perspective被引頻次
書目名稱Alcoholism: A Molecular Perspective被引頻次學科排名
書目名稱Alcoholism: A Molecular Perspective年度引用
書目名稱Alcoholism: A Molecular Perspective年度引用學科排名
書目名稱Alcoholism: A Molecular Perspective讀者反饋
書目名稱Alcoholism: A Molecular Perspective讀者反饋學科排名
作者: 莎草 時間: 2025-3-21 21:36
tel Il Ciocco in Tuscany during 26th August - 6th September 1990. Alcoholism remains one of the most challenging problems in medical care, with far-reaching medical, social and economic consequences. For example in the U. S. , estimates indicate that 18 million people have a serious drinking problem作者: cumber 時間: 2025-3-22 02:52 作者: 發(fā)微光 時間: 2025-3-22 05:51
Genetic Linkage Analysis: Simple Solutions for Complex Traits?,rse are currently unknown. In turn, this could lead to logical improvements in the way the disorder is treated. Furthermore, antenatal diagnosis and the identification of carriers could provide the opportunity for more accurate genetic counseling.作者: Injunction 時間: 2025-3-22 10:11
https://doi.org/10.1007/3-540-34416-0n. To understand these relationships it is important to have a basic concept of signal transduction (Fig. 1) (Gilman, 1989): agonist receptor interaction leads to replacement of GDP by GTP in the alpha sub segment of the G protein which then activates catalytic proteins such as adenylyl cyclase or phospholipase C or ion channels.作者: 致詞 時間: 2025-3-22 15:27
Book 1991cco in Tuscany during 26th August - 6th September 1990. Alcoholism remains one of the most challenging problems in medical care, with far-reaching medical, social and economic consequences. For example in the U. S. , estimates indicate that 18 million people have a serious drinking problem and that 作者: Density 時間: 2025-3-22 18:32 作者: Alveolar-Bone 時間: 2025-3-22 22:16
Data Science and Classificationf methodological differences (Videla and Valenzuela, 1982; Dianzani, 1985), and also because of the use of analytical techniques not always suitable for the detection of low levels of radical-associated tissue damage.作者: 沒有希望 時間: 2025-3-23 02:07 作者: Invertebrate 時間: 2025-3-23 06:19
Free Radical Mediated Reactions and Ethanol Toxicity: Some Considerations on the Methodological Appf methodological differences (Videla and Valenzuela, 1982; Dianzani, 1985), and also because of the use of analytical techniques not always suitable for the detection of low levels of radical-associated tissue damage.作者: Defiance 時間: 2025-3-23 12:34
Data Science and Digital Business; Marselos et al., 1979; Vasiliou et al., 1988). An increase in ALDH activity was also found in primary cultures of human or rat hepatocytes, after . exposure to PB or methylcholanthrene (Marselos and Michalopoulos, 1986; Marselos et al., 1987).作者: Legion 時間: 2025-3-23 14:36
Data Science and Emerging Technologiesvous system which result in drug resistance. The cellular adaptations to resist a drug’s actions are part of the phenomenon of “functional” tolerance and the processes that contribute to functional tolerance will be the focus of this discussion.作者: COLIC 時間: 2025-3-23 20:51 作者: CHIDE 時間: 2025-3-24 01:03
The Neurochemistry of Ethanol Tolerance,vous system which result in drug resistance. The cellular adaptations to resist a drug’s actions are part of the phenomenon of “functional” tolerance and the processes that contribute to functional tolerance will be the focus of this discussion.作者: achlorhydria 時間: 2025-3-24 04:49
Pathways of Ethanol Metabolism and Related Pathology,t to the reduced form (NADH) (Fig. 1). As a net result, ethanol oxidation by ADH generates an excess of reducing equivalents as free NADH in hepatic cytosol, primarily because the metabolic systems involved in NADH removal are not able to fully offset the accumulation of NADH. The acetaldehyde produ作者: atrophy 時間: 2025-3-24 08:52
Regulation of Rates of Ethanol Metabolism and Liver [NAD+]/[NADH] Ratio,row and Hardman, 1989). There have been two main theories as to the major rate limitation on the ethanol metabolic pathway. The first theory was that the rate at which NADH (generated in the alcohol and aldehyde dehydrogenase reactions) could be reoxidised to NAD. was limiting (Hawkins and Kalant, 1作者: legitimate 時間: 2025-3-24 13:11 作者: Transfusion 時間: 2025-3-24 15:37
Free Radical Mediated Reactions and Ethanol Toxicity: Some Considerations on the Methodological Apped new attention, and it is now generally accepted that oxidative damages might play a role in the pathogenesis of tissue damage due to alcohol abuse (Lieber, 1988). Nonetheless, it should be realized that since the early work of Di Luzio, who first suggested an involvement of lipid peroxidation in 作者: 比賽用背帶 時間: 2025-3-24 22:51
The Molecular Pathology of Alcoholic Liver Disease: An Overview, Through interaction of the receptor G protein and catalytic enzymes located in the plasma membrane ethanol alters the homeostasis of the cell. The signal transduction is either enhanced or inhibited by the action of alcohol, usually through the action of ethanol on the alpha subunit of the G protei作者: LUMEN 時間: 2025-3-25 02:37
Acetaldehyde Adducts and Excessive Alcohol Consumption,dehyde toxicity may be its ability to form covalent adducts with various proteins and cell constituents. The primary site of acetaldehyde adduct formation should be the liver, where it is believed to inhibit microtubule assembly, decrease enzyme activities and increase protein catabolism (Sorrell an作者: QUAIL 時間: 2025-3-25 03:46
Ethanol-Induced Phosphorylation of Cytokeratins in Primary Cultured Hepatocytes, and stability of intermediate filaments including intermediate filaments composed of cytokeratins (CKs). Initiation of the phosphorylation is through signal transduction by agonist receptor G protein activation of a catalyst such as cyclic AMP or phospholipase C which activate PKA or PKC, respectiv作者: 送秋波 時間: 2025-3-25 11:30
Cloning and Characterization of New Alcohol Dehydrogenase and Aldehyde Dehydrogenase Isozymes,dize varieties of alcohols and aldehydes, and play a role, not only in alcohol detoxification, but also in the metabolism of drugs, neurotransmitters and other endogenous biologically active alcohols and aldehydes.作者: cardiopulmonary 時間: 2025-3-25 13:18
Physiological Role of Aldehyde Dehydrogenase (EC 1.2.1.3),te specificity. Both specific and non-specific enzymes are active with acetaldehyde as substrate (Pietruszko, 1989). Aldehyde dehydrogenase (EC 1.2.1.3) from human liver and brain as well as some specific enzymes including glutamic-γ-semialdehyde dehydrogenase (EC 1.5.1.12) from human liver (Forte-M作者: 確定的事 時間: 2025-3-25 17:01
The Alcohol Dehydrogenase System in the Rat: Comparison with the Human Enzyme,.1.1) started early (Markovic et al., 1971; Arslanian et al., 1971) and continued more recently (Crabb et al., 1983; Lad and Leffert, 1983, Mezey and Potter, 1983). These reports focused on the liver form that is most active with ethanol. During the last decade a great amount of information has been作者: Aerate 時間: 2025-3-25 21:00 作者: misshapen 時間: 2025-3-26 01:10 作者: Astigmatism 時間: 2025-3-26 05:53
Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Their Significance for Alcohol-Related Prism of neurotransmitters, fatty acids and glutathione, and in clearance of biogenic toxic substances. Genetic abnormalities, and consequent alteration of activity and kinetic properties of any one of the ADH and ALDH isozymes would potentially affect one’s sensitivity to alcohol and vulnerability in作者: 盲信者 時間: 2025-3-26 10:12
Biochemical and Genetic Studies in ALDH1-Deficient Subjects,cal properties (Yoshida .., 1990). Liver mitochondrial aldehyde dehydrogenase (ALDH.) probably plays a major role in acetaldehyde metabolism as its low k. (1–2μM) is compatible with the circulating acetaldehyde levels after alcohol ingestion in both normal subjects and alcohol abusers (Arthur et al.作者: 會犯錯誤 時間: 2025-3-26 15:35 作者: 馬賽克 時間: 2025-3-26 17:59
Genetic Linkage Analysis: Simple Solutions for Complex Traits?,ajor goal with important implications. Such identification could greatly increase our understanding of diseases whose pathophysiology and clinical course are currently unknown. In turn, this could lead to logical improvements in the way the disorder is treated. Furthermore, antenatal diagnosis and t作者: 木訥 時間: 2025-3-27 00:36 作者: 責難 時間: 2025-3-27 02:24 作者: enfeeble 時間: 2025-3-27 09:08 作者: 沙文主義 時間: 2025-3-27 11:43 作者: Arthr- 時間: 2025-3-27 14:53
Crisp Partitions Induced by a Fuzzy Setght into the problem came from the experiments by Di Luzio and Costales (1964), showing a protective action of antioxidants on fatty liver following acute ethanol treatment in the rat. As lipid peroxidation had been shown to increase in CC1.-induced liver damage (Comporti et al., 1965; Recknagel and作者: Blemish 時間: 2025-3-27 20:50
Data Science and Classificationed new attention, and it is now generally accepted that oxidative damages might play a role in the pathogenesis of tissue damage due to alcohol abuse (Lieber, 1988). Nonetheless, it should be realized that since the early work of Di Luzio, who first suggested an involvement of lipid peroxidation in 作者: CRUC 時間: 2025-3-27 21:57
https://doi.org/10.1007/3-540-34416-0 Through interaction of the receptor G protein and catalytic enzymes located in the plasma membrane ethanol alters the homeostasis of the cell. The signal transduction is either enhanced or inhibited by the action of alcohol, usually through the action of ethanol on the alpha subunit of the G protei作者: textile 時間: 2025-3-28 05:52 作者: minion 時間: 2025-3-28 06:14
P. Raghu Vamsi,Aamir Ahmad,Vivek Dwivedi and stability of intermediate filaments including intermediate filaments composed of cytokeratins (CKs). Initiation of the phosphorylation is through signal transduction by agonist receptor G protein activation of a catalyst such as cyclic AMP or phospholipase C which activate PKA or PKC, respectiv作者: Coronary-Spasm 時間: 2025-3-28 13:26 作者: 性上癮 時間: 2025-3-28 18:25 作者: 血友病 時間: 2025-3-28 18:45
Arunkumar Narayanan,Meenakumari.1.1) started early (Markovic et al., 1971; Arslanian et al., 1971) and continued more recently (Crabb et al., 1983; Lad and Leffert, 1983, Mezey and Potter, 1983). These reports focused on the liver form that is most active with ethanol. During the last decade a great amount of information has been作者: 關節(jié)炎 時間: 2025-3-29 01:27 作者: Iniquitous 時間: 2025-3-29 05:16
Jinyoung Yang,Hyoboon Wang,Donghyuk Jopecies (Julià et al., 1987a) are divided into three classes, I, H and III, which are characterized by their specific, differing electrophoretic mobilities, reactivities with different alcohols and sensitivities to pyrazole and its derivatives. Class III alcohol dehydrogenases have anodic electrophor作者: 蜈蚣 時間: 2025-3-29 08:39 作者: antidepressant 時間: 2025-3-29 14:01
Data Science and Emerging Technologiescal properties (Yoshida .., 1990). Liver mitochondrial aldehyde dehydrogenase (ALDH.) probably plays a major role in acetaldehyde metabolism as its low k. (1–2μM) is compatible with the circulating acetaldehyde levels after alcohol ingestion in both normal subjects and alcohol abusers (Arthur et al.作者: 疏忽 時間: 2025-3-29 16:28 作者: Postulate 時間: 2025-3-29 23:46
Hadi Naghavipour,Farhad Nadi,Ali Aitizazajor goal with important implications. Such identification could greatly increase our understanding of diseases whose pathophysiology and clinical course are currently unknown. In turn, this could lead to logical improvements in the way the disorder is treated. Furthermore, antenatal diagnosis and t作者: OPINE 時間: 2025-3-30 02:40
Hadi Naghavipour,Farhad Nadi,Ali Aitizazse phenomena include ethanol-induced intoxication, reinforcement, the development of functional tolerance and physical dependence and ethanol-induced brain damage. One of the more popular hypotheses regarding the cellular and molecular mechanisms by which ethanol produces its effect on the CNS propo作者: 新義 時間: 2025-3-30 05:06 作者: 參考書目 時間: 2025-3-30 09:17
https://doi.org/10.1007/978-1-4684-5946-3Calcium; Pathogene; calcium channels; enzymes; metabolism作者: limber 時間: 2025-3-30 14:20 作者: 元音 時間: 2025-3-30 19:14
P. Raghu Vamsi,Aamir Ahmad,Vivek Dwivedi and stability of intermediate filaments including intermediate filaments composed of cytokeratins (CKs). Initiation of the phosphorylation is through signal transduction by agonist receptor G protein activation of a catalyst such as cyclic AMP or phospholipase C which activate PKA or PKC, respectively.作者: colostrum 時間: 2025-3-30 23:02
C. S. Anagha,Siddhaling Urolagindize varieties of alcohols and aldehydes, and play a role, not only in alcohol detoxification, but also in the metabolism of drugs, neurotransmitters and other endogenous biologically active alcohols and aldehydes.作者: Allodynia 時間: 2025-3-31 01:41 作者: progestogen 時間: 2025-3-31 07:46 作者: 無所不知 時間: 2025-3-31 10:45
Cloning and Characterization of New Alcohol Dehydrogenase and Aldehyde Dehydrogenase Isozymes,dize varieties of alcohols and aldehydes, and play a role, not only in alcohol detoxification, but also in the metabolism of drugs, neurotransmitters and other endogenous biologically active alcohols and aldehydes.作者: 評論者 時間: 2025-3-31 16:20
Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Their Significance for Alcohol-Related Prism of neurotransmitters, fatty acids and glutathione, and in clearance of biogenic toxic substances. Genetic abnormalities, and consequent alteration of activity and kinetic properties of any one of the ADH and ALDH isozymes would potentially affect one’s sensitivity to alcohol and vulnerability in developing alcohol-related problems.作者: 推遲 時間: 2025-3-31 18:15
NATO Science Series A:http://image.papertrans.cn/a/image/152317.jpg作者: 佛刊 時間: 2025-3-31 23:06 作者: Gerontology 時間: 2025-4-1 02:36 作者: Oratory 時間: 2025-4-1 06:24
Pathways of Ethanol Metabolism and Related Pathology,rovides reducing equivalents and two carbon units for lipid synthesis, 2) the more reduced redox state inhibits the oxidation of fatty acids and diverts them into esterification which is further enhanced by the increased concentration of sn-glycerol-3-phosphate, 3) ethanol affects the amount of fatt作者: 正論 時間: 2025-4-1 10:43 作者: Gratuitous 時間: 2025-4-1 15:39 作者: 暴發(fā)戶 時間: 2025-4-1 19:02
Physiological Role of Aldehyde Dehydrogenase (EC 1.2.1.3),Pietruszko, 1989) Among physiologically occurring aldehydes, biogenic aldehydes derived from dopamine, serotonin and norepinephrine (MacKerrell et al., 1986) as well as aldehyde metabolites of corticosteroids (Martin and Monder, 1978; Monder et al., 1982) are substrates for this enzyme. The Michaeli作者: 未成熟 時間: 2025-4-1 23:14
The Alcohol Dehydrogenase System in the Rat: Comparison with the Human Enzyme,ct isoenzymes: ADH-3 is the liver enzyme with properties similar to human class I; ADH-2, present in all the organs examined, appeared homologous to human class III; ADH-1, isolated from stomach, exhibited characteristics of class II (Julià et al., 1987). Structural studies of classes I and III supp作者: frugal 時間: 2025-4-2 04:05
Class III Alcohol Dehydrogenases: Evidence for Their Identity with the Glutathione-Dependent Formalclass III enzymes have been purified from human liver (Wagner et al., 1984) and brain (Beisswenger et al., 1985), and from the livers of horse (Kaiser et al., 1989), rat (Julià et al., 1987b) and mouse (Algar et al., 1983) but the physiological significance of these enzymes has remained obscure alth
