作者: Inoperable 時(shí)間: 2025-3-21 22:33
Conducting Polymer Nanostructures,research. Although most of centenarians remain independent in daily living until over 90s, about 97?% of them contracted chronic diseases including hypertension (63.6?%) and bone fracture (46.4?%). The prevalence of diabetes mellitus (DM) and carotid atherosclerotic plaque were peculiarities of cent作者: jealousy 時(shí)間: 2025-3-22 01:58 作者: GIST 時(shí)間: 2025-3-22 08:01
https://doi.org/10.1007/978-3-540-69323-9patients. Further, many elderly patients are waiting for new therapies for treatment of intractable age-related diseases such as Alzheimer’s disease, Parkinson’s disease, liver cirrhosis, lung failure and renal failure. The development of induced pluripotent stem cell (iPSC) technology opens the doo作者: arousal 時(shí)間: 2025-3-22 09:07 作者: BOOR 時(shí)間: 2025-3-22 16:57
https://doi.org/10.1007/978-981-287-038-4 budding yeast, have contributed to a better understanding of the complexity of aging and longevity. Budding yeast gradually loses the ability of producing daughter cells in rich media, and then loses viability in exhausted media during the aging process. According to these distinguishable losses, t作者: duplicate 時(shí)間: 2025-3-22 20:42 作者: 按等級(jí) 時(shí)間: 2025-3-22 21:50
John A. Wilkinson BSc, MCh, FRCS . have identified many genes and pathways that regulate aging, several of which are conserved in other species, including mammals. In this chapter, we describe longevity-regulatory pathways including insulin/IGF-1 (insulin-like growth factor 1) signaling, TOR (target of rapamycin) signaling, autoph作者: BRIEF 時(shí)間: 2025-3-23 03:27
Deformities of the anterior thoracic wall,ases have become the major threats to human health and serious social burdens worldwide. Recently, research in neurodegenerative diseases has entered the Renaissance age, as several genes responsible for the diseases were identified. In this chapter, we explain why . (.) is an excellent animal model作者: EWE 時(shí)間: 2025-3-23 07:19 作者: 悠然 時(shí)間: 2025-3-23 09:41
Suzanne M. Mannes,Stephanie M. Doanegulated by the expression of several age-related genes and a signaling pathway, including forkhead box O (FOXO) and neuropeptide Y (NPY). Heterozygous Foxo1-deficient mice under CR exhibit alterations in cancer development but not lifespan, indicating that FOXO1 contributes to anti-cancer effects in作者: 粗魯性質(zhì) 時(shí)間: 2025-3-23 15:51
Stan C. Kwasny,Kanaan A. Faisalh shows premature phenotypic changes. Kidney aging associated with a decline in kidney function affects the functions of remote organs (heart, blood vessels, and brain), and CKD is a significant risk factor in cardiovascular disease (CVD) and stroke, both of which are age-related diseases. This asso作者: 表臉 時(shí)間: 2025-3-23 19:25 作者: 洞察力 時(shí)間: 2025-3-24 01:08 作者: 大方不好 時(shí)間: 2025-3-24 05:11 作者: 兇兆 時(shí)間: 2025-3-24 07:00
http://image.papertrans.cn/a/image/151454.jpg作者: anticipate 時(shí)間: 2025-3-24 14:00
https://doi.org/10.1007/978-4-431-55763-0Aging; Brain; Longevity; Metabolism; Neurodegeneration作者: Androgen 時(shí)間: 2025-3-24 18:51 作者: ACE-inhibitor 時(shí)間: 2025-3-24 19:47
Congenital Displacement of the Hip Joints gained widespread favor for the study of many biological processes, including aging. Several lines of . research relating to oxidative stress and aging are discussed in this review, including the use of transgenic organisms with altered superoxide dismutase levels as well as studies that focus on mitochondrial mutations.作者: 不透氣 時(shí)間: 2025-3-25 02:05 作者: 潔凈 時(shí)間: 2025-3-25 06:12 作者: lobster 時(shí)間: 2025-3-25 10:05 作者: 珊瑚 時(shí)間: 2025-3-25 12:31
Aging-Related Neurodegenerative Diseases in , for the studies on neurodegenerative diseases and describe how this animal model has contributed to understanding of the mechanism of the diseases. Several features of . make it a particularly useful model for searching for genetic modifiers of disease phenotypes and for investigating the role of aging in disease development and progression.作者: ascend 時(shí)間: 2025-3-25 16:20 作者: GRAZE 時(shí)間: 2025-3-25 20:59
Conducting Polymer Nanostructures,c loss and neuronal elimination. The long-term cultured neurons in vitro seem to represent many similar aspects of physiological and possibly pathological aging that occur in vivo. The usefulness of this system as a new model for the investigation of non-replicative post-mitotic neuronal aging can be discussed.作者: 去才蔑視 時(shí)間: 2025-3-26 00:30 作者: 面包屑 時(shí)間: 2025-3-26 08:15 作者: 追逐 時(shí)間: 2025-3-26 09:53
In Vitro Aging Revisited: The Longevity of Cultured Neuronsc loss and neuronal elimination. The long-term cultured neurons in vitro seem to represent many similar aspects of physiological and possibly pathological aging that occur in vivo. The usefulness of this system as a new model for the investigation of non-replicative post-mitotic neuronal aging can be discussed.作者: 真實(shí)的人 時(shí)間: 2025-3-26 12:47
Role of the Forkhead Box O Family and Neuropeptide Y in Calorie Restrictionribute to CR benefits. Recently, CR effects have been examined in individuals, leading to development of CR mimetic compounds. This review summarizes the current insights into the molecular mechanisms linking regulation of age-related genes and CR benefits in mammals.作者: 輕率看法 時(shí)間: 2025-3-26 17:38 作者: Lamina 時(shí)間: 2025-3-27 00:45
Deformities of the anterior thoracic wall, for the studies on neurodegenerative diseases and describe how this animal model has contributed to understanding of the mechanism of the diseases. Several features of . make it a particularly useful model for searching for genetic modifiers of disease phenotypes and for investigating the role of aging in disease development and progression.作者: 油氈 時(shí)間: 2025-3-27 02:32 作者: 謊言 時(shí)間: 2025-3-27 08:47 作者: cortisol 時(shí)間: 2025-3-27 11:47 作者: obviate 時(shí)間: 2025-3-27 13:49 作者: 使激動(dòng) 時(shí)間: 2025-3-27 20:25
In Vitro Aging Revisited: The Longevity of Cultured Neuronsrmal fibroblasts have a limited “replicative” lifespan, which was later termed the Hayflick limit. This limit was a paradigm of the cellular senescence of dividing cells. In contrast, it is not well-known how non-dividing cells, such as neurons and muscles, grow and age in vitro over a long time cou作者: 異常 時(shí)間: 2025-3-28 00:05
Cellular Longevity of Budding Yeast During Replicative and Chronological Aging budding yeast, have contributed to a better understanding of the complexity of aging and longevity. Budding yeast gradually loses the ability of producing daughter cells in rich media, and then loses viability in exhausted media during the aging process. According to these distinguishable losses, t作者: cornucopia 時(shí)間: 2025-3-28 02:08 作者: 混雜人 時(shí)間: 2025-3-28 09:11 作者: 項(xiàng)目 時(shí)間: 2025-3-28 11:53 作者: 規(guī)范要多 時(shí)間: 2025-3-28 17:10
α-Klotho in Health and Diseasesssues that are involved in mineral homeostasis, and it encodes a 130-kDa type I glycoprotein. α-Kl was first predicted to localize to the cell surface. However, large amounts of α-Kl proteins have been detected in the intra-cellular space. In addition, the extra-cellular domain is cleaved, and secre作者: oncologist 時(shí)間: 2025-3-28 21:33 作者: Visual-Field 時(shí)間: 2025-3-28 23:01 作者: 騷擾 時(shí)間: 2025-3-29 06:18 作者: 眉毛 時(shí)間: 2025-3-29 09:45 作者: Indicative 時(shí)間: 2025-3-29 13:50 作者: handle 時(shí)間: 2025-3-29 15:45 作者: AMBI 時(shí)間: 2025-3-29 21:34
Cellular Longevity of Budding Yeast During Replicative and Chronological Aging., rapamycin). We reviewed methodological properties of CLS and RLS, and discussed genes related to these lifespans. Particularly, we focused on two genes, Sir2 and Tor1, in context of their association with replicative and chronological cellular aging. We also described novel genes and primary biol作者: 感情脆弱 時(shí)間: 2025-3-30 00:58
Genes and Pathways That Influence Longevity in ,ression of genes involved in each pathway and system alter longevity. We also speculate on the evolutionary significance of the genes and pathways that affect longevity. Given the conserved nature of longevity regulation, the dissection of the roles of these genetic factors in determining the . life作者: Bone-Scan 時(shí)間: 2025-3-30 06:36
α-Klotho in Health and Diseasesex to plasma membrane. On the membrane, α-Kl forms a ternary complex with FGF23 and FGFR1 and negatively regulates 1, 25(OH).D synthesis and phosphate re-absorption in the kidney. As a down-steam event of hypervitaminosis D and hyperphosphatemia, Calpain-1 is greatly activated and is responsible for作者: BRAND 時(shí)間: 2025-3-30 08:28
Oxidative Stress and Endoplasmic Reticulum Stress in Kidney Aging: Impact of Uremic Toxins as the Caave received attention as causal factors of a vicious cycle of these stress signals, resulting in progression of CKD, rather than being a consequence of CKD. This article summarizes the impact and pathophysiological significance of oxidative stress and glycative stress, and ER stress. It also discus作者: FLING 時(shí)間: 2025-3-30 16:05
Vitamin K Benefits in Aging and Cancerion. Analysis of the bones of pregnane X receptor (PXR)-deficient mice demonstrated that the bone protective effects of vitamin K are partially mediated by SXR/PXR-dependent signaling. In certain malignancies, vitamin K exerts therapeutic activity in an SXR/PXR-dependent manner. Another distinct fun
