標(biāo)題: Titlebook: Activity-Based Protein Profiling; Benjamin F. Cravatt,Ku-Lung Hsu,Eranthie Weerapana Book 2019 Springer Nature Switzerland AG 2019 Penicil [打印本頁] 作者: JAR 時間: 2025-3-21 17:01
書目名稱Activity-Based Protein Profiling影響因子(影響力)
書目名稱Activity-Based Protein Profiling影響因子(影響力)學(xué)科排名
書目名稱Activity-Based Protein Profiling網(wǎng)絡(luò)公開度
書目名稱Activity-Based Protein Profiling網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Activity-Based Protein Profiling被引頻次
書目名稱Activity-Based Protein Profiling被引頻次學(xué)科排名
書目名稱Activity-Based Protein Profiling年度引用
書目名稱Activity-Based Protein Profiling年度引用學(xué)科排名
書目名稱Activity-Based Protein Profiling讀者反饋
書目名稱Activity-Based Protein Profiling讀者反饋學(xué)科排名
作者: ABHOR 時間: 2025-3-21 23:22 作者: 泛濫 時間: 2025-3-22 02:19
https://doi.org/10.1007/978-3-662-05952-4se exhibit polypharmacology across the PARP family. In this review, we discuss the history, development, and current state of the field, highlighting the limitations and opportunities for PARP inhibitor development.作者: 原始 時間: 2025-3-22 07:19
Physikalische Grundlagen der Optik,lipids and the lipid–protein interaction profile. In this review, we will summarize the recent developments in the field of chemical probes to study lipid biology, especially in immunology, and indicate potential avenues for future research.作者: Barter 時間: 2025-3-22 10:08 作者: 地殼 時間: 2025-3-22 13:56
Entwicklung empirischer Methoden,ic profiling methods for their global analysis. We then summarize recent fatty-acylation profiling studies performed in eukaryotic pathogens and during bacterial infections, highlighting how they contribute to functional characterization of fatty-acylation under these contexts.作者: Priapism 時間: 2025-3-22 20:34
,Weiterführungen bisheriger Ergebnisse, Ub modifications, and subsequently controle and degrade these signals, is enormous. In this chapter, we will discuss the current state-of-the-art of activity-based probes, reporter substrates, and other relevant tools based on Ub as recognition element, to study the enzymes involved in the complex system of ubiquitination.作者: 含糊其辭 時間: 2025-3-22 21:55
,Abgasprüfungen - übersicht und Kritik,rm for high-throughput inhibitor discovery. This review will showcase the development of ABPPs targeting the PADs. In addition, it provides a brief overview of PAD structure and function along with recent advances in PAD inhibitor development.作者: iodides 時間: 2025-3-23 05:27 作者: 重疊 時間: 2025-3-23 06:29
Book 2019 science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and b作者: congenial 時間: 2025-3-23 12:30
Activity-Based Protein Profiling978-3-030-11143-4Series ISSN 0070-217X Series E-ISSN 2196-9965 作者: 要塞 時間: 2025-3-23 16:10
https://doi.org/10.1007/978-3-030-11143-4Penicillin-binding proteins; Poly-ADP-ribosylation; Host-virus interactions; Intramembrane proteases; Cy作者: 離開就切除 時間: 2025-3-23 20:21 作者: 種子 時間: 2025-3-23 23:16
Benjamin F. Cravatt,Ku-Lung Hsu,Eranthie WeerapanaProvides new insights into activity-based protein profiling (ABPP), which uses chemical probes to profile the functional state of enzymes in native biological systems.Focuses on the application of ABP作者: Spinous-Process 時間: 2025-3-24 03:16 作者: 意見一致 時間: 2025-3-24 06:33
https://doi.org/10.1007/978-3-642-61039-4Though their essentiality to life is clear, the mechanistic underpinnings of community structure, interactions, and functions are largely unexplored and in need of function-dependent technologies to unravel the mysteries. Activity-based protein profiling offers unprecedented molecular-level characte作者: HALL 時間: 2025-3-24 12:28 作者: Excise 時間: 2025-3-24 16:57 作者: 預(yù)兆好 時間: 2025-3-24 19:22
Entwicklung empirischer Methoden,obes. Using probes that target catalytically active enzymes, ABPP can rapidly define the functional proteome of a biological system. In recent years, this approach has been increasingly applied to globally profile enzymes active at the host–pathogen interface of microbial infections. From in vitro c作者: beta-carotene 時間: 2025-3-25 00:02
Entwicklung empirischer Methoden,ods have provided new opportunities to explore protein fatty-acylation in microbial pathogens. Recent studies suggest that protein fatty-acylation is essential to survival and pathogenesis of eukaryotic pathogens such as parasites and fungi. Moreover, fatty-acylation in host cells can be exploited o作者: 蝕刻術(shù) 時間: 2025-3-25 03:52
,Weiterführungen bisheriger Ergebnisse,) has the unique ability to form eight different lysine-linked polymeric chains, mixed chains and engages with ubiquitin-like (Ubl) molecules. The distinct signals evoked by specific enzymes play a crucial role in, for instance, proteasome-mediated protein degradation, cell cycle regulation, and DNA作者: 嘮叨 時間: 2025-3-25 10:21 作者: 清楚 時間: 2025-3-25 15:04
Automobil, Verkehr und Erziehungeir parasitic life cycles. While the development of technologies for genetic engineering has revolutionised the field of functional genomics, parasites have historically been less amenable to such modification. In light of this, parasitologists have often been at the forefront of adopting new small-作者: ingestion 時間: 2025-3-25 19:44
Schallwahrnehmung des Menschen,es to block checkpoint inhibition of T cell activity and thus reawaken the patient’s antitumor immune responses are rapidly becoming standard of care for treatment of diverse cancers. Adoptive transfer of patient T cells genetically engineered with tumor-targeting capabilities is redefining the fiel作者: 無孔 時間: 2025-3-25 23:11 作者: 用樹皮 時間: 2025-3-26 01:03 作者: 疾馳 時間: 2025-3-26 05:07
https://doi.org/10.1007/978-3-642-79649-4hod to study protease biology and the design of protease probes has pushed the boundaries of ABPP. The development of highly selective protease probes is still a challenging task. After an introduction, the first section of this chapter discusses several strategies to enable detection of a single ac作者: overwrought 時間: 2025-3-26 09:58
Physikalische Grundlagen der Optik,e mode of action of many signaling lipids has remained elusive due to their low abundance, high lipophilicity, and inherent instability. Various chemical biology approaches, such as photoaffinity or activity-based protein profiling methods, have been employed to shed light on the biological role of 作者: Conjuction 時間: 2025-3-26 16:02
https://doi.org/10.1007/978-3-642-85709-6of therapeutic potential, and their behavior as virulence factors and signaling molecules. The NRPs are biosynthesized independently of the ribosome by enzyme assembly lines known as the non-ribosomal peptide synthetase (NRPS) machinery. Genetic, biochemical, and bioinformatics analyses have provide作者: 截?cái)?nbsp; 時間: 2025-3-26 17:33 作者: ARM 時間: 2025-3-27 00:22
,Ger?uschquellen des Fahrzeugs,ion of both dynamic and structural disulfides. Often posttranslationally modified, cysteines are also frequently alkylated by electrophilic compounds, including electrophilic metabolites, drugs, and natural products, and are attractive sites for covalent probe and drug development. Quantitative prot作者: CROW 時間: 2025-3-27 04:12 作者: Irrepressible 時間: 2025-3-27 08:58 作者: Esophagus 時間: 2025-3-27 12:29 作者: Femish 時間: 2025-3-27 13:38
Activity-Based Protein Profiling for the Study of Parasite Biology,978-1-4615-7416-3作者: 鬧劇 時間: 2025-3-27 18:53
Front Matterripotent stem cells in the presence of conditioned medium of cancer cells, the study on the mechanism of metastasis has become practically possible..In this chapter, we evaluate the detailed steps of cancer stem cell preparation and injection into spleen and tail vein. This process will help underst作者: 反抗者 時間: 2025-3-27 23:14
,Activity-Based Protein Profiling—Enabling Multimodal Functional Studies of Microbial Communities,ved in volatile organic solvents such as diethyl ether and coated at desired concentrations onto surfaces (for tests as settlement cues or antifouling agents); onto palatable prey that have been blotted dry; or onto finely powdered, dried algal or animal tissue that can then be imbedded in a gel mat作者: Living-Will 時間: 2025-3-28 06:10
Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophilm. The better understanding of aminoglycoside distribution and elimination is a direct consequence of an improved methodology for determination of drug levels and of a more refined data analysis. Therefore, it conforms to the subject of this symposium to review some of the problems connected with th作者: LEERY 時間: 2025-3-28 10:20
Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria, investigators have become doubtful about the validity of this simple hypothesis (Ghose & Coppen, 1977; Leonard, 1980), it is now being argued that depressive disorders are biochemically heterogenous conditions where deficiency of either 5-hydroxytryptamine (5-HT) or NA is the primary aetiological f作者: 濕潤 時間: 2025-3-28 10:43
,ABPP and Host–Virus Interactions,nerated using digital methods providing the researcher with unprecedented possibilities for stimulus control and experimental design. The strategies and paradigms for data collection and analysis are becoming more refined as well, again due in large part to the widespread use of computers. In this v作者: 新陳代謝 時間: 2025-3-28 14:47 作者: 孵卵器 時間: 2025-3-28 21:42 作者: 生意行為 時間: 2025-3-29 01:22 作者: parasite 時間: 2025-3-29 03:41
Recent Advances in Activity-Based Protein Profiling of Proteases,hy of science arguments tend to make people forget that we must continue to find ways of tackling the concrete methodological questions about how to produce relevant and plausible research results (Howarth and Torfing 2005). In any case, there are very few studies addressing the ‘nitty-gritty’ of co作者: forthy 時間: 2025-3-29 08:08 作者: BIBLE 時間: 2025-3-29 13:59 作者: 發(fā)炎 時間: 2025-3-29 18:47
Target Identification of Bioactive Covalently Acting Natural Products,version offeedinto end products, which can impact on the- imal and theenvironment. As the livestock sector grows particularly in developing countries, there will be an increasing need to understand these processes for b- ter management and use ofbothfeed and other natural resources that underpinthe 作者: glacial 時間: 2025-3-29 20:17 作者: 綁架 時間: 2025-3-30 01:10
0070-217X iples of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions. .978-3-030-11143-4Series ISSN 0070-217X Series E-ISSN 2196-9965 作者: 瘋狂 時間: 2025-3-30 04:56
https://doi.org/10.1007/978-3-642-61039-4of the biological applications of ABPP in microbes and microbial communities, and highlight potential areas for development. The future of ABPP holds real promise for understanding and considerable impact in microbiome studies associated with personalized medicine, precision agriculture, veterinary 作者: 奇思怪想 時間: 2025-3-30 10:38 作者: osculate 時間: 2025-3-30 13:11
https://doi.org/10.1007/978-3-211-79196-7eveloping inhibitors. Here we seek to contextualize progress thus far with achieving these goals and highlight the unique challenges and opportunities for activity-based probes to further our understanding of protein function and regulation, bacterial physiology, and antibiotic development.作者: 支形吊燈 時間: 2025-3-30 19:03
Automobil, Verkehr und Erziehungtive and practicable tools with which to interrogate the regulation of enzymes’ catalytic activity and the roles played by these enzymes in various cell processes. This paper will review the contributions of these techniques in characterising the roles of both host and viral enzymes during viral inf作者: 美食家 時間: 2025-3-30 21:21
