標(biāo)題: Titlebook: A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment; Natàlia Garcia-Reyero,Cheryl A. Murphy Book 2018 Spr [打印本頁] 作者: 建筑物的正面 時(shí)間: 2025-3-21 17:12
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書目名稱A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment讀者反饋學(xué)科排名
作者: regale 時(shí)間: 2025-3-21 23:38 作者: Prognosis 時(shí)間: 2025-3-22 04:13 作者: TRAWL 時(shí)間: 2025-3-22 04:39 作者: FOLLY 時(shí)間: 2025-3-22 11:26 作者: osteoclasts 時(shí)間: 2025-3-22 13:39 作者: Functional 時(shí)間: 2025-3-22 20:28
.Combines all computational and molecular tools together forSocial pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. 作者: 矛盾 時(shí)間: 2025-3-22 23:24 作者: 含沙射影 時(shí)間: 2025-3-23 03:51
Book 2018edictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse healt作者: 小樣他閑聊 時(shí)間: 2025-3-23 07:33 作者: 高貴領(lǐng)導(dǎo) 時(shí)間: 2025-3-23 12:10
978-3-030-09758-5Springer International Publishing AG 2018作者: sphincter 時(shí)間: 2025-3-23 15:44 作者: lesion 時(shí)間: 2025-3-23 21:33
http://image.papertrans.cn/a/image/142391.jpg作者: 褲子 時(shí)間: 2025-3-24 00:11 作者: 可卡 時(shí)間: 2025-3-24 04:58
Current Chinese Economic Report Seriesd hormone pathways, and is one of the only regulatory programs designed around a mode of action framework. A variety of biological systems affect apical endpoints used in regulatory risk assessments and without mechanistic data, endocrine disruption cannot be determined. When the EDSP was developed 作者: 抗體 時(shí)間: 2025-3-24 07:49 作者: ellagic-acid 時(shí)間: 2025-3-24 12:06
Current Chinese Economic Report Seriesre more cost-efficient compared to tests using adult fish while maintaining the physiological relevance of a vertebrate whole-organism test system. Ethical considerations are also a driver for the use of fish embryos since they are considered alternative testing models during the early stages of dev作者: 桉樹 時(shí)間: 2025-3-24 17:32 作者: 顧客 時(shí)間: 2025-3-24 20:43 作者: 壯觀的游行 時(shí)間: 2025-3-25 02:25
Xingmin Gao,Feng Qiu,Jinhong Xull be required to construct AOPs for exposures to different chemical groups making sure that we have enough representation of different test species to adequately cover the tree of life. This should include plants, which have not yet received sufficient attention from the AOP community. In this chap作者: MERIT 時(shí)間: 2025-3-25 06:34
Haiping Luo,Zhaopeng Yu,Jingyi Zhou, physiological, and environmental stimuli, in the development of Adverse Outcome Pathway (AOP) models. In recent years, zebrafish have been extensively investigated for their potential as a model organism in behavioral toxicology due to their low maintenance cost and similarities with rodent behavi作者: 不安 時(shí)間: 2025-3-25 08:33
Ruoyu Zhong,Wen Tang,Zhigui Guan and when considered in the context of the adverse outcome pathway (AOP) framework. Omics data provide individual snapshots of gene expression, protein expression and metabolite activity. When integrated, these individual snapshots yield deep biological insights. Omics can provide mechanistic inform作者: essential-fats 時(shí)間: 2025-3-25 12:00 作者: CAMEO 時(shí)間: 2025-3-25 19:06 作者: 同義聯(lián)想法 時(shí)間: 2025-3-25 23:51
Yiming Yuan,Chunhong Sheng,Ping Lvhroughout (HT) in vitro dose response data and in vivo biological outcomes. However, AOP development has also been met with challenges of its own, such as the time, effort, and expertise necessary to achieve a scientifically sound construct able to support ecotoxicology and human health risk assessm作者: 嚴(yán)重傷害 時(shí)間: 2025-3-26 00:33 作者: Limerick 時(shí)間: 2025-3-26 07:05
https://doi.org/10.1007/978-981-99-6667-7ed to inform ecological risk assessments come primarily from tests on individual organisms or from suborganismal studies, indicating a disconnect between primary data and protection goals. We know how to relate individual responses to population dynamics using individual-based models, and there are 作者: Obverse 時(shí)間: 2025-3-26 08:43 作者: lymphedema 時(shí)間: 2025-3-26 15:36
Yiming Yuan,Hai Xie,Mengdie Chenan contain up to 250 different contaminants and has been linked to reproductive impairment in fish. We used data from an in vitro study that characterized the potential neurochemical effects of pulp and paper mill effluent, to model vitellogenin production after exposure to different effluent fracti作者: 檢查 時(shí)間: 2025-3-26 20:14
https://doi.org/10.1007/978-981-13-9837-7 recent years promote the large-scale use of mechanistic information, organized in the form of pathways at different levels of biological organization as a basis to underpin a dramatic change in the way chemical assessment is performed. As a result, there now exist international collaborations to de作者: Tincture 時(shí)間: 2025-3-26 22:16
https://doi.org/10.1007/978-981-13-9837-7isations the opportunity to jointly collect and discuss their knowledge about the biological and toxicological processes leading to an Adverse Outcome. While this knowledge becomes more distributed and accepted by the scientific mainstream, its acceptance in a regulatory context is still not well de作者: labile 時(shí)間: 2025-3-27 03:55
https://doi.org/10.1007/978-981-13-9837-7ical polarization that currently exists around environmental regulations. Given this context, any gaps, assumptions, or uncertainties associated with AOPs are likely to receive intense scrutiny whenever they have regulatory implications that could generate adverse consequences for particular stakeho作者: monochromatic 時(shí)間: 2025-3-27 08:22 作者: thrombus 時(shí)間: 2025-3-27 11:16 作者: 搜尋 時(shí)間: 2025-3-27 16:46 作者: HEW 時(shí)間: 2025-3-27 18:55
The Fish Embryo as a Model for AOP Development,r industrial components continues to be met by unregulated production often based in domestic premises. Although this portion of Third World production was for a long time ignored by development planners and financial backers, its existence is increasingly being recognised and its potential for incr作者: granite 時(shí)間: 2025-3-28 01:57 作者: GEAR 時(shí)間: 2025-3-28 04:13 作者: fibula 時(shí)間: 2025-3-28 07:54
Green Algae and Networks for Adverse Outcome Pathways,yse von Auswirkungen der Konsumentenvernetzung auf die Notwendigkeit Kunden auszugrenzen und die Analyse der Ver?nderung von Wirkungsweisen ausgrenzungspolitischer Marketingma?nahmen. Die Erreichung dieser Ziele macht es zun?chst erforderlich aufzuzeigen, welche Kunden als unerwünscht zu deklarieren作者: altruism 時(shí)間: 2025-3-28 13:30 作者: 清晰 時(shí)間: 2025-3-28 16:08 作者: anticipate 時(shí)間: 2025-3-28 19:40 作者: custody 時(shí)間: 2025-3-29 00:10
Linking Adverse Outcome Pathways to Dynamic Energy Budgets: A Conceptual Model,sikers und unser Tisch zwei verschiedene Dinge, die in keiner relevanten Beziehung zueinander stünden. W?hrend wir auf der einen Seite durchaus bereit sind, dem Physiker einzur?umen, daB . Tisch für ihn ein h?chst wichtiger und nützlicher Gegenstand ist, sind wir auf der anderen Seite mit . Tisch ge作者: invade 時(shí)間: 2025-3-29 06:42 作者: 交響樂 時(shí)間: 2025-3-29 08:01
Using a Vitellogenesis Model to Link in vitro Neurochemical Effects of Pulp and Paper Mill Effluentsollte er erst am 30. Januar 1649 zu spüren bekommen. An diesem Tag wurde Karl I. in H?rweite der Westminster School gek?pft, w?hrend der Schulleiter seine Schüler für ihren K?nig beten lie?. Wie sehr dieses Ereignis Europa auch erschüttert haben mag, für Locke ging das Leben weiter.作者: Neolithic 時(shí)間: 2025-3-29 12:23
Use of Adverse Outcome Pathways in Human Risk Assessment and Toxicology, Jahren (1947) . Frage auf die Physik zu übertragen versuchte, meinte noch ?Wirsehen von denen ab, die Physik als Brotstudium ergreifen und betreiben, sie stehen unterhalb des Nullpunktes unserer Wertskala“. Diese Abwertung erschient kurios, voe allem wenn sie aus dem Munde eines beamteten Physik Pr作者: antecedence 時(shí)間: 2025-3-29 15:57
The Future of Adverse Outcome Pathways: Analyzing their Social Context,rises the research within the neuropsychiatric field, but also gives an overview of the underlying biochemistry and of diagnostic aspects. About 1,000 references are given. Christina Bolander-Gouaille, a pharmacist, has for over 10 years specialised in writing reviews/monographs on homocysteine and 作者: fiscal 時(shí)間: 2025-3-29 21:14 作者: stratum-corneum 時(shí)間: 2025-3-30 01:17
Cell-Free Assays in Environmental Toxicology,their support. It also creates employment opportunities, at the SMEs as well as for the pool of retirees from financial institutions who can help assess the projects..Introduction of the hometown investment fun978-4-431-54753-2978-4-431-54309-1作者: LAST 時(shí)間: 2025-3-30 04:52 作者: CUMB 時(shí)間: 2025-3-30 11:43 作者: 一條卷發(fā) 時(shí)間: 2025-3-30 14:28 作者: 異端邪說2 時(shí)間: 2025-3-30 18:23 作者: Coronary 時(shí)間: 2025-3-30 22:14
Xingmin Gao,Feng Qiu,Jinhong Xurative phylogenetic approach to ecotoxicological testing, seeking to discover the evolutionary origins and distribution of toxicity pathways across the internal branches of the animal phylogeny. Comparative –omics data from cellular and developmental studies suggest a high degree of conservation in 作者: VAN 時(shí)間: 2025-3-31 00:58 作者: Handedness 時(shí)間: 2025-3-31 07:01
Haiping Luo,Zhaopeng Yu,Jingyi Zhoul review studies in which behavioral phenotypes and neurophysiological outcomes have been anchored to specific molecular initiating events induced by a chemical exposure. Although the study of the genetic and physiological basis of behavior is still nascent, there are many noteworthy studies that ha作者: JUST 時(shí)間: 2025-3-31 10:47
Ruoyu Zhong,Wen Tang,Zhigui Guanry framework, and how to use AOPs to drive regulatory decision-making processes. In this chapter, an overview of major omics is provided that includes recent advances and describes the potential application of omics data to the development of AOPS while defining some of the challenges associated wit作者: 津貼 時(shí)間: 2025-3-31 16:42
Yiming Yuan,Chunhong Sheng,Ping LvT data (e.g., transcriptomic data) with traditional toxicology information spanning a broad chemical and biological space, computationally predicted AOPs can be rapidly generated to help accelerate the curation of AOPs. AOPs are chemical agnostic thereby allowing a single AOP to be coupled with in v作者: 經(jīng)典 時(shí)間: 2025-3-31 19:33 作者: cancer 時(shí)間: 2025-3-31 23:30 作者: 確認(rèn) 時(shí)間: 2025-4-1 02:51 作者: left-ventricle 時(shí)間: 2025-4-1 09:32
https://doi.org/10.1007/978-981-13-9837-7entre (JRC) to develop a public knowledge base for building AOPs on a large scale. Although this direction is fairly new, there are many pathways already in development. In addition, pathway-based approaches are increasingly being applied to a variety of assessments of hazard in a number of sectors.作者: 我要威脅 時(shí)間: 2025-4-1 13:54
