作者: 調(diào)整校對 時(shí)間: 2025-3-21 22:01 作者: 違反 時(shí)間: 2025-3-22 01:22 作者: ITCH 時(shí)間: 2025-3-22 07:53 作者: PURG 時(shí)間: 2025-3-22 10:38
Waldenstr?m Macroglobulinaemia: Pathological Features and Diagnostic Assessmentd in advances in diagnosis, prognostic assessment and post-treatment response evaluation. Similarly the demonstration of the MYD88 L265P mutation and its biologic effect has resulted in major therapeutic advances and improved survival outcomes for patients.作者: promote 時(shí)間: 2025-3-22 13:05
Unusual Manifestations of IgM Monoclonal Gammopathiestion or even of a MGUS; the so-called “dangerous” small B-cell clone and monoclonal gammopathy of renal significance. This chapter describes IgM-related AL amyloidosis and the skin and kidney manifestations of IgM gammopathies, which are not uncommon and could in some cases involve other mechanisms than deposition or autoantibody activity.作者: Mitigate 時(shí)間: 2025-3-22 20:38 作者: 武器 時(shí)間: 2025-3-22 23:51
Genetic Predisposition to Waldenstr?m Macroglobulinemiain providing both the basis and substrate for ongoing genetic studies aimed at identifying WM predisposition genes. Together, these investigations may help elucidate the host genetic factors underlying WM development and more broadly may provide insights into the aging immune system.作者: Condyle 時(shí)間: 2025-3-23 02:15
Unusual Manifestations of IgM Monoclonal Gammopathiestion or even of a MGUS; the so-called “dangerous” small B-cell clone and monoclonal gammopathy of renal significance. This chapter describes IgM-related AL amyloidosis and the skin and kidney manifestations of IgM gammopathies, which are not uncommon and could in some cases involve other mechanisms than deposition or autoantibody activity.作者: 規(guī)范就好 時(shí)間: 2025-3-23 08:58
Epidemiology of Waldenstr?m Macroglobulinemiah the median age of diagnosis is around 70 years. Known risk factors for WM include family history and chronic antigen stimulation (i.e. chronic infections and autoimmune diseases), and IgM MGUS, which can be thought of as an early state of WM. Over recent decades there have been evidence of increased survival over time.作者: defeatist 時(shí)間: 2025-3-23 13:40 作者: 彈藥 時(shí)間: 2025-3-23 15:28 作者: 缺乏 時(shí)間: 2025-3-23 20:12 作者: 藝術(shù) 時(shí)間: 2025-3-24 01:00
Genetic and Signaling Abnormalities in Waldenstrom’s Macroglobulinemiaent and bone marrow infiltration at diagnosis. Mutant MYD88 drives critical BTK and HCK signaling and is highly predictive of response to the BTK inhibitor ibrutinib. Additional characteristics of these and other recurrent genomic alterations such as ARID1A and CD79B mutations as well as chromosome 6q deletions are discussed.作者: Preamble 時(shí)間: 2025-3-24 06:12 作者: 多節(jié) 時(shí)間: 2025-3-24 07:56
Genetic and Signaling Abnormalities in Waldenstrom’s Macroglobulinemiaent and bone marrow infiltration at diagnosis. Mutant MYD88 drives critical BTK and HCK signaling and is highly predictive of response to the BTK inhibitor ibrutinib. Additional characteristics of these and other recurrent genomic alterations such as ARID1A and CD79B mutations as well as chromosome 6q deletions are discussed.作者: 助記 時(shí)間: 2025-3-24 11:00 作者: 亞麻制品 時(shí)間: 2025-3-24 17:49 作者: 間諜活動(dòng) 時(shí)間: 2025-3-24 22:16
Molecular Pathways in Growth and Survival: Epigenomicsuch as Waldenstrom’s Macroglobulinemia (WM). Importantly, recent evidences have suggested that WM cells present with an aberrant histone acetylation status, and this may be due to deregulated microRNA profiling within the WM tumor clone, thus providing the preclinical support for using miRNA-based therapies in this disease.作者: Biofeedback 時(shí)間: 2025-3-25 02:35
Hyperviscosity Syndrome, Cold Agglutinin Hemolytic Anemia, and Cryoglobulinemiatial presentation. Prompt recognition and therapy are keys to effective management. Urgent plasmapheresis is indicated for symptomatic hyperviscosity syndrome (HVS). Proper collection of blood specimens is essential for accurate interpretation in cold agglutinin and cryoglobulinemia patients.作者: 小樣他閑聊 時(shí)間: 2025-3-25 06:09
Waldenstr?m Macroglobulinaemia: Pathological Features and Diagnostic Assessmenty lymphoplasmacytic lymphoma (LPL). Historically LPL has been considered a poorly reproducible diagnostic category and largely a diagnosis of exclusion as a consequence of a lack of disease defining immunophenotypic and genotypic features. Considerable advances have been made recently with the demon作者: BYRE 時(shí)間: 2025-3-25 08:12 作者: 貞潔 時(shí)間: 2025-3-25 11:53 作者: Acumen 時(shí)間: 2025-3-25 19:27 作者: 賞心悅目 時(shí)間: 2025-3-25 21:59 作者: connoisseur 時(shí)間: 2025-3-26 00:29 作者: 云狀 時(shí)間: 2025-3-26 05:23 作者: 鞠躬 時(shí)間: 2025-3-26 09:25 作者: 大洪水 時(shí)間: 2025-3-26 14:02 作者: 卵石 時(shí)間: 2025-3-26 18:47
Genetic Predisposition to Waldenstr?m MacroglobulinemiaGUS recognized as a precursor condition for WM. Following early observations of clustering of WM (and IgM-MGUS) in families, several lines of evidence have developed that support the hypothesis of a genetic component of WM susceptibility. Family studies have provided seminal observations in delineat作者: 有花 時(shí)間: 2025-3-26 22:47
Immunoglobulin Type M Monoclonal Gammopathy of Undetermined Significance (IgM-MGUS)noclonal gammopathy of undetermined significance (MGUS) is diagnosed in a patient who presents with a monoclonal gammopathy in the absence of histologic evidence, signs, or symptoms of a malignant lymphoproliferative or plasmacytic disorder. MGUS is among the most common premalignant conditions in W作者: Latency 時(shí)間: 2025-3-27 01:47 作者: Foregery 時(shí)間: 2025-3-27 08:33 作者: glans-penis 時(shí)間: 2025-3-27 10:16
IgM Amyloidosis and rapid decline of vital organ function. Four percent are associated with an IgM monoclonal protein. Early diagnosis is vital in order to deliver effective therapy and prevent irreversible organ damage. Accurate diagnosis requires clinical skills and advanced technologies. The disease can be halt作者: Mortal 時(shí)間: 2025-3-27 16:25
Waldenstr?m Macroglobulinaemia: Pathological Features and Diagnostic Assessmenty lymphoplasmacytic lymphoma (LPL). Historically LPL has been considered a poorly reproducible diagnostic category and largely a diagnosis of exclusion as a consequence of a lack of disease defining immunophenotypic and genotypic features. Considerable advances have been made recently with the demon作者: Arthr- 時(shí)間: 2025-3-27 18:53
The Bing-Neel Syndromethe autoimmune effects of paraprotein production, and via vessel damage from hypercoagulation and hyperviscosity. The “Bing-Neel syndrome” (BNS) is a clinicopathologic entity that encompasses two of these mechanisms: central nervous system (CNS) invasion by WM lymphoplasmacytic (LPC) cells and rarel作者: 貪心 時(shí)間: 2025-3-28 01:47 作者: 抵制 時(shí)間: 2025-3-28 03:20 作者: SOBER 時(shí)間: 2025-3-28 07:35 作者: Etymology 時(shí)間: 2025-3-28 13:25
Cytogenetics in Waldenstr?m Macroglobulinemia (WM)isease. Chromosomal abnormalities are not specific to WM, but the frequency and association of these aberrations distinguish WM from other B-cell malignancies. Deletion of the long arm of chromosome 6 (6q deletion) is the most frequent abnormality. Trisomy 4, particularly associated with trisomy 18,作者: 招待 時(shí)間: 2025-3-28 15:12 作者: Bridle 時(shí)間: 2025-3-28 22:09
Molecular Pathways in Growth and Survival: Epigenomicsetic markers is histone acetylation which has been shown to be deregulated in clonal disorders, including both solid tumors and B-cell malignancies, such as Waldenstrom’s Macroglobulinemia (WM). Importantly, recent evidences have suggested that WM cells present with an aberrant histone acetylation s作者: 微不足道 時(shí)間: 2025-3-29 00:11
The Bone Marrow Microenvironment and Tumor Cells Interactions in Waldenstr?m’s Macroglobulinemia(BM) is always involved and infiltrated by the monoclonal lymphoplasmacytic cells. Within the BM microenvironment WM cells thrive and produce IgM. BM microenvironment plays a critical role in the progression of the disease from the stage of MGUS to asymptomatic and symptomatic WM, and a permissive B作者: 發(fā)酵 時(shí)間: 2025-3-29 04:42
Waldenstrom’s Macroglobulinaemia: Immunosurveillance and the Immune Micro-environmentnaemia (WM), there are measurable changes in the immune system with abnormalities of T-cells, NK cells and the ability to respond to external immunological stimuli. The homeostatic balance between the activation and suppression of immune antitumour effector cells in vivo is controlled by a network o作者: 移植 時(shí)間: 2025-3-29 10:05 作者: 清楚 時(shí)間: 2025-3-29 14:14
Genetic Predisposition to Waldenstr?m MacroglobulinemiaGUS recognized as a precursor condition for WM. Following early observations of clustering of WM (and IgM-MGUS) in families, several lines of evidence have developed that support the hypothesis of a genetic component of WM susceptibility. Family studies have provided seminal observations in delineat作者: CUB 時(shí)間: 2025-3-29 19:00 作者: ABHOR 時(shí)間: 2025-3-29 23:32 作者: 生命層 時(shí)間: 2025-3-30 00:52 作者: 大廳 時(shí)間: 2025-3-30 05:08 作者: 蹣跚 時(shí)間: 2025-3-30 09:14 作者: Bridle 時(shí)間: 2025-3-30 13:15
Unusual Manifestations of IgM Monoclonal Gammopathieson, lymphadenopathy and splenomegaly, symptoms due to the monoclonal IgM, either by deposition of all or part of its molecule or because of a symptomatic auto-antibody activity. Some of these IgM-related manifestations, such as hyperviscosity, occur in presence of high tumour mass proliferation. Oth作者: 絕緣 時(shí)間: 2025-3-30 19:51
Book 2017n of widely-recognized experts, involved in this field. It represents the efforts of physicians, scientists and patients, all around the world, to better understand and cure this rare disease..Considerable advances in the diagnosis, treatment indications, response criteria, prognostic factors and tr作者: WAIL 時(shí)間: 2025-3-30 21:55 作者: MILL 時(shí)間: 2025-3-31 04:27 作者: Nefarious 時(shí)間: 2025-3-31 06:04
Florence Nguyen-Khacochastische Abh?ngigkeiten (das hei?t stochastische Ursache-Wirkung-Beziehungen) durch Funktionen zu beschreiben. Konkrete Beispiele derartiger stochastischer Abh?ngigkeiten sind die Abh?ngigkeit eines Ernteertrags von der durchschnittlichen Niederschlagsmenge im Monat Mai, die Abh?ngigkeit der L?sb作者: Oratory 時(shí)間: 2025-3-31 11:37
Zachary R. Hunter PhD,Guang Yang PhD,Lian Xu MA,Xia Liu MD,Jorge J. Castillo MD,Steven P. Treon MD, en in den allgemeinen Lehrbüchern der mathematischen Statistik meist überhaupt nicht erw?hnt; gelegentlich werden sie nur ganz kurz gestreift. Monographien, die sich mit der statistischen Auswertung von Prozentzahlen befassen, sind nur in englischer Sprache erschienen; wir erw?hnen die Werke von D. 作者: Loathe 時(shí)間: 2025-3-31 14:25
Vilhjálmur Steingrímsson,Ola Landgren,Sigureur Yngvi Kristinsson MD, PhDdelt, besagt bekanntlich, da? die Quantoren sich nur auf Individuenvariable, nicht jedoch auf Pr?dikatenvariable erstrecken dürfen. . m?gen durch kleine Buchstaben aus dem Ende des Alphabetes bezeichnet werden, also etwa durch ., ., .; . durch Buchstaben aus dem Anfang des Alphabetes, also z. B. dur作者: Latency 時(shí)間: 2025-3-31 20:25
Mary L. McMaster,Helga M. ?gmundsdóttirer industriellen Revolution die Spezialisierung der Arbeit immer weiter vorangetrieben worden ist und da? in den heutigen Fabriken nahezu alle Arbeit durch Facharbeiter ausgeführt wird. Da die verwendeten Maschinen im allgemeinen sehr kompliziert sind und die Arbeiter immer speziellere Arbeit verric作者: miscreant 時(shí)間: 2025-4-1 01:15
Mary L. McMaster,Helga M. ?gmundsdóttir,Sigurdur Y. Kristinsson,Robert A. Kyleon den Bundesstaaten (L?ndern) auf Veranlassung des Reichs durchgeführt. Diese Erhebungen beginnen im neuen Reich mit dem Jahre 1873. Der Bundesratsbeschlu? vom 28. Juni 1872 sieht vor, da? ?in allen Staaten des Deutschen Reichs jedes fünfte Jahr eine Ermittlung der Viehhaltung nach gleichm??igen Gr作者: 寄生蟲 時(shí)間: 2025-4-1 05:22
Zachary R. Hunter PhD,Guang Yang PhD,Lian Xu MA,Xia Liu MD,Jorge J. Castillo MD,Steven P. Treon MD, neu zu schaf- fenden Objekte der neuen Technik st?ndig w?chst. Die meisten derartigen Objekte sind komplizierte Gebilde, die aus zahlreichen Aggregaten, Mechanismen, Ger?ten, Automatisierungs-und Kommunikationselementen usw. bestehen. Zu derartigen kom- plizierten Systemen geh?ren z. B. kosmische Fl作者: 充氣女 時(shí)間: 2025-4-1 08:43
Antonio Sacco,Michele Moschetta,Salomon Manier,Giuseppe Rossi,Irene M. Ghobrial,Aldo M. Roccaro MD, itativen Merkmalen (die im allgemeinen durch Messen ermittelt werden) ist die beobachtete ph?notypische Varianz eine Folge der kombinierten Umwelt- und Genotyp- bzw. Genwirkung. Der genetisch bedingte Merkmalswert wird durch die Umwelteffekte maskiert und kann als solcher nicht ermittelt werden. Das作者: 訓(xùn)誡 時(shí)間: 2025-4-1 12:32
D. E. Joshua,R. Brown,P. J. Ho,J. Gibson,H. Suenzu entt?uschen, seien einige Bemerkungen zum Zweck und Aufbau des Buches vorangestellt. Die Anwendung anspruchsvollerer statistischer Verfahren hat sich in den letzten Jahren in zunehmendem Ma? in der Geographie durchgesetzt. Der überwiegende Teil der deutschen geographischen Institute bietet bereit作者: 隨意 時(shí)間: 2025-4-1 15:10
Mary L. McMaster,Helga M. ?gmundsdóttir,Sigurdur Y. Kristinsson,Robert A. Kyle Verhalten dieser Systeme. Im Laufe dieser Untersuchungen haben wir verschiedene nützliche Parameter eingeführt (wie W?rme, absolute Temperatur, Entropie), mit denen das . Verhalten von Vielteilchensystemen beschrieben werden kann. Obwohl diese Parameter anhand mikroskopischer Begriffe sorgf?ltigst 作者: Range-Of-Motion 時(shí)間: 2025-4-1 21:12 作者: 褲子 時(shí)間: 2025-4-2 01:56 作者: entitle 時(shí)間: 2025-4-2 04:43 作者: Creditee 時(shí)間: 2025-4-2 07:35
K. Ina Ly,Florian Fintelmann,Reza Forghani,Ephraim P. Hochberg,Fred H. Hochbergt, sofern es sich um . handelt. Die Molekülzustandssumme . l??t sich im Prinzip immer berechnen, wenn die quantenmechanischen Energieniveaus ε. mit ihrem Entartungsgrad g. bekannt sind. Bei zwei- und mehratomigen Molekülen gibt es wegen der überlagerung verschiedener Bewegungsformen (Translation und作者: 干旱 時(shí)間: 2025-4-2 12:27
Véronique Leblond,Steve Treon,Meletios DimoploulosTimely international book on this rare disease.Brings updates on clinical, biological and therapeutic data.Edited by the three world experts with contributions from high-profile authors, world leaders作者: 廣告 時(shí)間: 2025-4-2 17:01 作者: 思考 時(shí)間: 2025-4-2 23:06
http://image.papertrans.cn/w/image/1020326.jpg作者: 大范圍流行 時(shí)間: 2025-4-3 01:09 作者: ADJ 時(shí)間: 2025-4-3 07:25 作者: hedonic 時(shí)間: 2025-4-3 10:39 作者: Cupping 時(shí)間: 2025-4-3 15:58
Efstathios Kastritis,Aldo Roccaro,Magdalini Migou,Irene Ghobrial
